Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H9F3N2O2 |
| Molecular Weight | 282.218 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
OC(=O)C1=CN=CC=C1NC2=CC(=CC=C2)C(F)(F)F
InChI
InChIKey=NLBIKXOJCISNQP-UHFFFAOYSA-N
InChI=1S/C13H9F3N2O2/c14-13(15,16)8-2-1-3-9(6-8)18-11-4-5-17-7-10(11)12(19)20/h1-7H,(H,17,18)(H,19,20)
| Molecular Formula | C13H9F3N2O2 |
| Molecular Weight | 282.218 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Triflocin is a nicotinic acid derivative. Triflocin is a diuretic agent. It is structurally dissimilar from ethacrynic acid and furosemide although their natriuretic potency and site of action in the kidney appear similar. Triflocin inhibits sodium-stimulated, ouabain-insensitive ATPase. In vivo, a natriuretic effect of Triflocin has been reported in both the proximal convoluted tubule and the thick ascending limb of Henle's loop. Upon acute isohydric hypercapnia, Triflocin depolarizes the basolateral membrane potential. Triflocin inhibits the basolateral electrogenic Na-(HCO3)n > 1 cotransport in proximal tubules.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Micropuncture study of the effect of triflocin on tubular reabsorption in rats. | 1973 Feb |
|
| Triflocin, a novel inhibitor for the Na-HCO3 symport in the proximal tubule. | 1994 Jun |
|
| Effect of locally applied drugs on the pH of luminal fluid in the endolymphatic sac of guinea pig. | 2000 Nov |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:22:54 GMT 2023
by
admin
on
Fri Dec 15 15:22:54 GMT 2023
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| Record UNII |
S01B3A38SK
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| Record Status |
Validated (UNII)
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| Record Version |
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-
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NCI_THESAURUS |
C448
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13422-16-7
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S01B3A38SK
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25969
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2827
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C76648
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C047090
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SUB11284MIG
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100000077742
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CHEMBL2104493
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| Related Record | Type | Details | ||
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SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |
