Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H8F3N2O2.Na |
| Molecular Weight | 304.1998 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[O-]C(=O)C1=CN=CC=C1NC2=CC(=CC=C2)C(F)(F)F
InChI
InChIKey=YOUXBFJNMBEOPV-UHFFFAOYSA-M
InChI=1S/C13H9F3N2O2.Na/c14-13(15,16)8-2-1-3-9(6-8)18-11-4-5-17-7-10(11)12(19)20;/h1-7H,(H,17,18)(H,19,20);/q;+1/p-1
| Molecular Formula | C13H8F3N2O2 |
| Molecular Weight | 281.21 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.98976928 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Triflocin is a nicotinic acid derivative. Triflocin is a diuretic agent. It is structurally dissimilar from ethacrynic acid and furosemide although their natriuretic potency and site of action in the kidney appear similar. Triflocin inhibits sodium-stimulated, ouabain-insensitive ATPase. In vivo, a natriuretic effect of Triflocin has been reported in both the proximal convoluted tubule and the thick ascending limb of Henle's loop. Upon acute isohydric hypercapnia, Triflocin depolarizes the basolateral membrane potential. Triflocin inhibits the basolateral electrogenic Na-(HCO3)n > 1 cotransport in proximal tubules.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effect of locally applied drugs on the pH of luminal fluid in the endolymphatic sac of guinea pig. | 2000-11 |
|
| Triflocin, a novel inhibitor for the Na-HCO3 symport in the proximal tubule. | 1994-06 |
|
| Characterization and localization of ouabain-insensitive Na-dependent ATPase activities along the rat nephron. | 1991-05-07 |
|
| Ouabain insensitive Na+-stimulated ATPase activity associated to basal-lateral plasma membranes of rat kidney cells. | 1983 |
|
| Partial characterization of the ouabain-insensitive, Na+-stimulated ATPase activity of kidney basal-lateral plasma membranes. | 1982-10-22 |
|
| Interference with feedback control of glomerular filtration rate by furosemide, triflocin, and cyanide. | 1974-06 |
|
| Micropuncture study of the effect of triflocin on tubular reabsorption in rats. | 1973-02 |
|
| The effect of triflocin, a new diuretic drug, on the renal concentrating mechanism. | 1972-10-01 |
|
| Effects of triflocin on renal tubular reabsorption and blood flow distribution. | 1972-07 |
|
| Ouabain-uninhibited Na+ Transport in human erythrocytes: the effects of triflocin. | 1972-02-11 |
|
| Renal mechanisms of the natriuretic and antiphosphaturic effects of triflocin--a new diuretic. | 1970-08 |
|
| The effect of a new diuretic, triflocin (4-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinic acid) on blood glucose in the rat and dog. | 1969-09 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Mon Mar 31 17:54:24 GMT 2025
by
admin
on
Mon Mar 31 17:54:24 GMT 2025
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| Record UNII |
C391E67F4Z
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| Record Status |
Validated (UNII)
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| Record Version |
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Preferred Name | English | ||
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Common Name | English |
| Code System | Code | Type | Description | ||
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C391E67F4Z
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13856-39-8
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DTXSID80160712
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admin on Mon Mar 31 17:54:24 GMT 2025 , Edited by admin on Mon Mar 31 17:54:24 GMT 2025
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71586970
Created by
admin on Mon Mar 31 17:54:24 GMT 2025 , Edited by admin on Mon Mar 31 17:54:24 GMT 2025
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PARENT -> SALT/SOLVATE |
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ACTIVE MOIETY |