Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C13H8F3N2O2.Na |
| Molecular Weight | 304.1998 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[Na+].[O-]C(=O)C1=CN=CC=C1NC2=CC=CC(=C2)C(F)(F)F
InChI
InChIKey=YOUXBFJNMBEOPV-UHFFFAOYSA-M
InChI=1S/C13H9F3N2O2.Na/c14-13(15,16)8-2-1-3-9(6-8)18-11-4-5-17-7-10(11)12(19)20;/h1-7H,(H,17,18)(H,19,20);/q;+1/p-1
| Molecular Formula | C13H8F3N2O2 |
| Molecular Weight | 281.21 |
| Charge | -1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
| Molecular Formula | Na |
| Molecular Weight | 22.9898 |
| Charge | 1 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Triflocin is a nicotinic acid derivative. Triflocin is a diuretic agent. It is structurally dissimilar from ethacrynic acid and furosemide although their natriuretic potency and site of action in the kidney appear similar. Triflocin inhibits sodium-stimulated, ouabain-insensitive ATPase. In vivo, a natriuretic effect of Triflocin has been reported in both the proximal convoluted tubule and the thick ascending limb of Henle's loop. Upon acute isohydric hypercapnia, Triflocin depolarizes the basolateral membrane potential. Triflocin inhibits the basolateral electrogenic Na-(HCO3)n > 1 cotransport in proximal tubules.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| The effect of a new diuretic, triflocin (4-(alpha,alpha,alpha-trifluoro-m-toluidino)-nicotinic acid) on blood glucose in the rat and dog. | 1969 Sep |
|
| Effects of triflocin on renal tubular reabsorption and blood flow distribution. | 1972 Jul |
|
| Micropuncture study of the effect of triflocin on tubular reabsorption in rats. | 1973 Feb |
|
| Characterization and localization of ouabain-insensitive Na-dependent ATPase activities along the rat nephron. | 1991 May 7 |
Patents
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:20:10 GMT 2023
by
admin
on
Fri Dec 15 15:20:10 GMT 2023
|
| Record UNII |
C391E67F4Z
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
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C391E67F4Z
Created by
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13856-39-8
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DTXSID80160712
Created by
admin on Fri Dec 15 15:20:10 GMT 2023 , Edited by admin on Fri Dec 15 15:20:10 GMT 2023
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71586970
Created by
admin on Fri Dec 15 15:20:10 GMT 2023 , Edited by admin on Fri Dec 15 15:20:10 GMT 2023
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| Related Record | Type | Details | ||
|---|---|---|---|---|
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PARENT -> SALT/SOLVATE |
| Related Record | Type | Details | ||
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ACTIVE MOIETY |