LUMASIRAN

Approval Year

Substance Class	Nucleic Acid
Nucleic Acid Type	RNAI
Nucleic Acid Subtype
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	RZT8C352O1
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LUMASIRAN

Official Name

English

LUMASIRAN [USAN]

Common Name

English

RNA, (GM-SP-AM-SP-CM-UM-UM-UM-(2'-DEOXY-2'-FLUORO)C-AM-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-UM-GM-GM-AM-AM-AM-UM-AM-UM-AM), 3'-(((2S,4R)-1-(29-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-14,14-BIS((3-((3-((5-((2-

Systematic Name

English

ALN-65585

Code

English

((2S,4R)-1-(1-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-16,16-BIS((3-((3-(5-((2-ACETAMIDO-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)PENTANAMIDO)PROPYL)AMINO)-3-OXOPROPOXY)METHYL)-5,11,18-TRIOXO-14-OXA-6,10,17-TRIAZANONACOSAN-29-OYL)-4-HYDROXYPYRRO

Systematic Name

English

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Classification Tree

Code System

Code

Designated/Approved

FDA ORPHAN DRUG

505315

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Code System

Code

Type

Description

USAN

GH-49

PRIMARY

CAS

1834610-13-7

PRIMARY

INN

10684

PRIMARY

FDA UNII

RZT8C352O1

PRIMARY

DAILYMED

RZT8C352O1

PRIMARY

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Subunit 0

Subunit 1

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Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_7;1_9-1_11;1_22;2_2;2_6;2_8-2_9;2_14;2_16	11 / 45
2'-O-Methyl-Ribose	1_1-1_6;1_8;1_12-1_21;2_1;2_3-2_5;2_7;2_10-2_13;2_15;2_17-2_23	34 / 45