U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Substance Class Nucleic Acid
Created
by admin
on Sat Dec 16 17:37:14 GMT 2023
Edited
by admin
on Sat Dec 16 17:37:14 GMT 2023
Nucleic Acid Type RNAI
Nucleic Acid Subtype
Sequence Origin HUMAN
Sequence Type COMPLETE
Record UNII
67P6XH37HD
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
LUMASIRAN SODIUM
Official Name English
RNA, (GM-SP-AM-SP-CM-UM-UM-UM-(2'-DEOXY-2'-FLUORO)C-AM-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-UM-GM-GM-AM-AM-AM-UM-AM-UM-AM), 3'-(((2S,4R)-1-(29-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-14,14-BIS((3-((3-((5-((2-
Systematic Name English
ALN-G01 SODIUM
Code English
Lumasiran sodium [WHO-DD]
Common Name English
ALN-65585 SODIUM
Code English
ALN-GO1 SODIUM
Code English
LUMASIRAN SODIUM [ORANGE BOOK]
Common Name English
AD-65585 SODIUM
Code English
OXLUMO
Brand Name English
Code System Code Type Description
RXCUI
2467161
Created by admin on Sat Dec 16 17:37:14 GMT 2023 , Edited by admin on Sat Dec 16 17:37:14 GMT 2023
PRIMARY
FDA UNII
67P6XH37HD
Created by admin on Sat Dec 16 17:37:14 GMT 2023 , Edited by admin on Sat Dec 16 17:37:14 GMT 2023
PRIMARY
CAS
1834612-06-4
Created by admin on Sat Dec 16 17:37:14 GMT 2023 , Edited by admin on Sat Dec 16 17:37:14 GMT 2023
PRIMARY
Sugar Site Range Site Count
2'-Fluoro-Ribose 1_7;1_9-1_11;1_22;2_2;2_6;2_8-2_9;2_14;2_16 11 / 45
2'-O-Methyl-Ribose 1_1-1_6;1_8;1_12-1_21;2_1;2_3-2_5;2_7;2_10-2_13;2_15;2_17-2_23 34 / 45
Linkage Site Range Site Count
Sodium Phosporothioate 1_2-1_3;2_2-2_3;2_22-2_23 6 / 43
1_4-1_22;2_4-2_21 37 / 43
Related Record Type Details
PARENT -> SALT/SOLVATE
Related Record Type Details
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
NUCLEOTIDE SUBSTITUTION [1_22] SITE_SPECIFIC GIVOSIRAN SODIUM TRIGLYCAN-END GROUP 8142CN1H73