LUMASIRAN SODIUM

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 09:21:05 GMT 2025` Edited by `admin` on `Wed Apr 02 09:21:05 GMT 2025`
Nucleic Acid Type	RNAI
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	67P6XH37HD
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

LUMASIRAN SODIUM

Official Name

English

ALN-65585 SODIUM

Preferred Name

English

RNA, (GM-SP-AM-SP-CM-UM-UM-UM-(2'-DEOXY-2'-FLUORO)C-AM-(2'-DEOXY-2'-FLUORO)U-(2'-DEOXY-2'-FLUORO)C-(2'-DEOXY-2'-FLUORO)C-UM-GM-GM-AM-AM-AM-UM-AM-UM-AM), 3'-(((2S,4R)-1-(29-((2-(ACETYLAMINO)-2-DEOXY-.BETA.-D-GALACTOPYRANOSYL)OXY)-14,14-BIS((3-((3-((5-((2-

Systematic Name

English

ALN-G01 SODIUM

Code

English

Lumasiran sodium [WHO-DD]

Common Name

English

ALN-GO1 SODIUM

Code

English

LUMASIRAN SODIUM [ORANGE BOOK]

Common Name

English

AD-65585 SODIUM

Code

English

OXLUMO

Brand Name

English

Code System Code Type Description

RXCUI

2467161

Created by admin on Wed Apr 02 09:21:05 GMT 2025 , Edited by admin on Wed Apr 02 09:21:05 GMT 2025

PRIMARY

SMS_ID

300000013944

Created by admin on Wed Apr 02 09:21:05 GMT 2025 , Edited by admin on Wed Apr 02 09:21:05 GMT 2025

PRIMARY

FDA UNII

67P6XH37HD

Created by admin on Wed Apr 02 09:21:05 GMT 2025 , Edited by admin on Wed Apr 02 09:21:05 GMT 2025

PRIMARY

CAS

1834612-06-4

Created by admin on Wed Apr 02 09:21:05 GMT 2025 , Edited by admin on Wed Apr 02 09:21:05 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
2'-Fluoro-Ribose	1_7;1_9-1_11;1_22;2_2;2_6;2_8-2_9;2_14;2_16	11 / 45
2'-O-Methyl-Ribose	1_1-1_6;1_8;1_12-1_21;2_1;2_3-2_5;2_7;2_10-2_13;2_15;2_17-2_23	34 / 45

Linkage	Site Range	Site Count
Sodium Phosporothioate	1_2-1_3;2_2-2_3;2_22-2_23	6 / 43
	1_4-1_22;2_4-2_21	37 / 43

Related Record Type Details


					RZT8C352O1

LUMASIRAN

PARENT -> SALT/SOLVATE

Amount:

Related Record Type Details


					RZT8C352O1

LUMASIRAN

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_22]	SITE_SPECIFIC			GIVOSIRAN SODIUM TRIGLYCAN-END GROUP	8142CN1H73