Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C6H17N3 |
| Molecular Weight | 131.2193 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
NCCCNCCCN
InChI
InChIKey=OTBHHUPVCYLGQO-UHFFFAOYSA-N
InChI=1S/C6H17N3/c7-3-1-5-9-6-2-4-8/h9H,1-8H2
| Molecular Formula | C6H17N3 |
| Molecular Weight | 131.2193 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
DescriptionCurator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3255245 | https://www.ncbi.nlm.nih.gov/pubmed/3140710 | https://www.ncbi.nlm.nih.gov/pubmed/23418450 |
http://www.abcam.com/dpta-nonoate-dipropylenetriamine-nonoate-ab145198.html
Curator's Comment: Description was created based on several sources, including https://www.ncbi.nlm.nih.gov/pubmed/3255245 | https://www.ncbi.nlm.nih.gov/pubmed/3140710 | https://www.ncbi.nlm.nih.gov/pubmed/23418450 |
http://www.abcam.com/dpta-nonoate-dipropylenetriamine-nonoate-ab145198.html
Norspermidine (1,7-diamino-4-azaheptane or dipropylenetriamine) is a structural homologue of the natural polyamine spermidine. Norspermidine and its metal complexes exert antineoplastic properties. Dipropylenetriamine NONOate is used as a donor of nitric oxide.
Originator
Sources: https://books.google.ru/books?id=wXp2vBr8L98C&printsec=frontcover&hl=ru#v=onepage&q&f=false
Curator's Comment: In 1962, Johson and Markham first reported the isolation of norspermidine (1,7-diamino-4-azaheptane or dipropylenetriamine) from turnip yellow mosaic virus and several other purified plant viruses, in which it appeared to be associated with the viral RNA.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Polyamines of the thermophilic eubacteria belonging to the genera Thermosipho, Thermaerobacter and Caldicellulosiruptor. | 2001 |
|
| Polyamines of the hyperthermophilic archaebacteria belonging to the genera Thermococcus and Methanothermus and two new genera Caldivirga and Palaeococcus. | 2001 |
|
| Effects of exogenous polyamines on growth, toxicity, and toxin profile of dinoflagellate Alexandrium minutum. | 2003 Feb |
|
| Oxamato-bridged trinuclear NiIICuIINiII complexes: a new (NiIICuIINiII)2 hexanuclear complex and supramolecular structures. Characterization and magnetic properties. | 2003 May 19 |
|
| Cellular polyamines of the acidophilic, thermophilic and thermoacidophilic archaebacteria, Acidilobus, Ferroplasma, Pyrobaculum, Pyrococcus, Staphylothermus, Thermococcus, Thermodiscus and Vulcanisaeta. | 2003 Oct |
|
| Preparation of gemini-type amphiphiles bearing cyclitol head groups and their application as high-performance modifiers for lipases. | 2004 Feb 25 |
|
| Polyamines of primitive apterygotan insects: springtails, silverfish and a bristletail. | 2004 Jan |
|
| Nitric oxide covalently labels a 6-hydroxydopa-derived free radical intermediate in the catalytic cycle of copper/quinone-containing amine oxidase from lentil seedlings. | 2005 Jan |
|
| A three-dimensional ferromagnet, [Ni(dipn)]3[Cr(CN)6]2.3H2O (dipn = dipropylene triamine), based on a cubic Cr8Ni12 unit. | 2006 Sep 4 |
|
| Adaptations to submarine hydrothermal environments exemplified by the genome of Nautilia profundicola. | 2009 Feb |
|
| Polyamine biosynthetic diversity in plants and algae. | 2010 Jul |
Sample Use Guides
In Vivo Use Guide
Curator's Comment: Norspermidine (Nspd), a homologue of spermidine, had significant antitumor activity against L1210 leukemia, 3LL carcinoma and EL4 lymphoma in mice.
Unknown
Route of Administration:
Unknown
High-dose norspermidine (1,7-diamino-4-azaheptane or dipropylenetriamine) had bactericide effect on P. aeruginosa, and norspermidine began to inhibit biofilm formation and eradicate 24-h mature biofilm at concentration of 0.1 and 1 mmol/L, respectively, probably by preventing cell-surface attachment, inhibiting swimming motility, and downregulating QS-related genes expression.
| Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 01:49:33 GMT 2023
by
admin
on
Sat Dec 16 01:49:33 GMT 2023
|
| Record UNII |
RN1144MGND
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Official Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Common Name | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
Norspermidine
Created by
admin on Sat Dec 16 01:49:33 GMT 2023 , Edited by admin on Sat Dec 16 01:49:33 GMT 2023
|
PRIMARY | |||
|
DTXSID0025440
Created by
admin on Sat Dec 16 01:49:33 GMT 2023 , Edited by admin on Sat Dec 16 01:49:33 GMT 2023
|
PRIMARY | |||
|
56-18-8
Created by
admin on Sat Dec 16 01:49:33 GMT 2023 , Edited by admin on Sat Dec 16 01:49:33 GMT 2023
|
PRIMARY | |||
|
7773
Created by
admin on Sat Dec 16 01:49:33 GMT 2023 , Edited by admin on Sat Dec 16 01:49:33 GMT 2023
|
PRIMARY | |||
|
RN1144MGND
Created by
admin on Sat Dec 16 01:49:33 GMT 2023 , Edited by admin on Sat Dec 16 01:49:33 GMT 2023
|
PRIMARY | |||
|
16841
Created by
admin on Sat Dec 16 01:49:33 GMT 2023 , Edited by admin on Sat Dec 16 01:49:33 GMT 2023
|
PRIMARY | |||
|
5942
Created by
admin on Sat Dec 16 01:49:33 GMT 2023 , Edited by admin on Sat Dec 16 01:49:33 GMT 2023
|
PRIMARY | |||
|
200-261-2
Created by
admin on Sat Dec 16 01:49:33 GMT 2023 , Edited by admin on Sat Dec 16 01:49:33 GMT 2023
|
PRIMARY |