Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C14H17ClN4S |
| Molecular Weight | 308.83 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
ClC1=CC=C(CNC(=N)SCCCC2=CN=CN2)C=C1
InChI
InChIKey=UCAIEVHKDLMIFL-UHFFFAOYSA-N
InChI=1S/C14H17ClN4S/c15-12-5-3-11(4-6-12)8-18-14(16)20-7-1-2-13-9-17-10-19-13/h3-6,9-10H,1-2,7-8H2,(H2,16,18)(H,17,19)
| Molecular Formula | C14H17ClN4S |
| Molecular Weight | 308.83 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Effects of histamine H3 receptor agonists and antagonists on cognitive performance and scopolamine-induced amnesia. | 1999 Oct |
|
| Identification of a histamine H(3)-like receptor in the zebrafish (Danio rerio) brain. | 2000 Aug |
|
| Distinct pharmacology of rat and human histamine H(3) receptors: role of two amino acids in the third transmembrane domain. | 2000 Dec |
|
| Cloning of rat histamine H(3) receptor reveals distinct species pharmacological profiles. | 2000 Jun |
|
| Genomic organization and characterization of splice variants of the human histamine H3 receptor. | 2001 Apr 15 |
|
| Histaminergic modulation of GABAergic transmission in rat ventromedial hypothalamic neurones. | 2001 Aug 1 |
|
| Constitutive activity of histamine h(3) receptors stably expressed in SK-N-MC cells: display of agonism and inverse agonism by H(3) antagonists. | 2001 Dec |
|
| H3 receptor-mediated inhibition of intestinal acetylcholine release: pharmacological characterization of signal transduction pathways. | 2001 Feb |
|
| Cortical acetylcholine release elicited by stimulation of histamine H1 receptors in the nucleus basalis magnocellularis: a dual-probe microdialysis study in the freely moving rat. | 2001 Jan |
|
| The rat H3 receptor: gene organization and multiple isoforms. | 2001 Jan 12 |
|
| [Identification and characterization of histamine H4 receptor]. | 2001 Jul |
|
| Influence of imidazole replacement in different structural classes of histamine H(3)-receptor antagonists. | 2001 Jun |
|
| Cloning and characterization of a novel human histamine receptor. | 2001 Mar |
|
| Cloning and pharmacological characterization of a fourth histamine receptor (H(4)) expressed in bone marrow. | 2001 Mar |
|
| [Role of central histamine in amygdaloid kindled seizures]. | 2001 May |
|
| Dynamics of histamine H(3) receptor antagonists on brain histamine metabolism: do all histamine H(3) receptor antagonists act at a single site? | 2001 Nov 16 |
|
| Comparison of human, mouse, rat, and guinea pig histamine H4 receptors reveals substantial pharmacological species variation. | 2001 Oct |
|
| Differential in vivo effects of H3 receptor ligands in a new mouse dipsogenia model. | 2002 Jun |
|
| Activation of the extraneuronal monoamine transporter (EMT) from rat expressed in 293 cells. | 2002 Nov |
|
| Ligands for histamine H(3) receptors modulate cell proliferation and migration in rat oxyntic mucosa. | 2002 Sep |
|
| Replacement of imidazole by a piperidine moiety differentially affects the potency of histamine H3-receptor antagonists. | 2003 Jan |
|
| Histamine induces cytoskeletal changes in human eosinophils via the H(4) receptor. | 2003 Nov |
|
| Effects of endogenous histamine on seizure development of pentylenetetrazole-induced kindling in rats. | 2003 Sep |
|
| Histamine H3 receptor activation inhibits dopamine D1 receptor-induced cAMP accumulation in rat striatal slices. | 2004 Jul 8 |
|
| [Mechanisms of the effect of brain histamine on chronic epilepsy induced by pentylenetetrazole]. | 2004 May |
|
| Effect of the histamine H3-antagonist clobenpropit on spatial memory deficits induced by MK-801 as evaluated by radial maze in Sprague-Dawley rats. | 2004 May 5 |
|
| Histamine (H3) receptors modulate the excitatory amino acid receptor response of the vestibular afferents. | 2005 Dec 7 |
|
| Histamine-3 receptor antagonists reduce superoxide anion generation and lipid peroxidation in rat brain homogenates. | 2005 Jun |
|
| Influence of intracerebroventricular administration of histaminergic drugs on morphine state-dependent memory in the step-down passive avoidance test. | 2005 May |
|
| Cross state-dependent retrieval between histamine and lithium. | 2005 Sep 15 |
|
| Histamine excites neonatal rat sympathetic preganglionic neurons in vitro via activation of H1 receptors. | 2006 Apr |
|
| Histamine increases sickle erythrocyte adherence to endothelium. | 2006 Feb |
|
| N-(4-Trifluoromethylphenyl)amide group of the synthetic histamine receptor agonist inhibits nicotinic acetylcholine receptor-mediated catecholamine secretion. | 2006 Feb 28 |
|
| Effects of intracerebroventricular administration of ultra low doses of histaminergic drugs on morphine state-dependent memory of passive avoidance in mice. | 2006 Jan 6 |
|
| STAT1 phosphorylation and cleavage is regulated by the histamine (H4) receptor in human atopic and non-atopic lymphocytes. | 2006 Oct |
|
| Role of apolipoprotein E in anxiety. | 2007 |
|
| Role of histamine in ghrelin-induced gastroprotection against acute gastric lesions. | 2007 Apr |
|
| Histamine downregulates monocyte CCL2 production through the histamine H4 receptor. | 2007 Aug |
|
| Pre-synaptic histamine H3 receptors regulate glutamate, but not GABA release in rat thalamus. | 2007 Feb |
|
| The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes. | 2007 Jul 19 |
|
| [Reversing effect of histamine on neurotoxicity induced by beta-amyloid1-42]. | 2007 Mar |
|
| Histamine augments beta2-adrenoceptor-induced cyclic AMP accumulation in human prostate cancer cells DU-145 independently of known histamine receptors. | 2007 Mar 15 |
|
| Substance P is involved in the effect of histamine H3 receptor agonist, Sch 50971 on nasal allergic symptoms in mice. | 2008 Aug |
|
| Human inflammatory dendritic epidermal cells express a functional histamine H4 receptor. | 2008 Jul |
|
| Antagonist affinity measurements at the Gi-coupled human histamine H3 receptor expressed in CHO cells. | 2008 Jun 6 |
|
| Apomorphine-induced turning behavior in 6-hydroxydopamine lesioned rats is increased by histidine and decreased by histidine decarboxylase, histamine H1 and H2 receptor antagonists, and an H3 receptor agonist. | 2008 Sep |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 16 23:47:14 UTC 2022
by
admin
on
Fri Dec 16 23:47:14 UTC 2022
|
| Record UNII |
RKU631JF4H
|
| Record Status |
Validated (UNII)
|
| Record Version |
|
-
Download
| Name | Type | Language | ||
|---|---|---|---|---|
|
Common Name | English | ||
|
Code | English | ||
|
Systematic Name | English |
| Code System | Code | Type | Description | ||
|---|---|---|---|---|---|
|
145231-45-4
Created by
admin on Fri Dec 16 23:47:14 UTC 2022 , Edited by admin on Fri Dec 16 23:47:14 UTC 2022
|
PRIMARY | |||
|
DTXSID3043738
Created by
admin on Fri Dec 16 23:47:14 UTC 2022 , Edited by admin on Fri Dec 16 23:47:14 UTC 2022
|
PRIMARY | |||
|
Clobenpropit
Created by
admin on Fri Dec 16 23:47:14 UTC 2022 , Edited by admin on Fri Dec 16 23:47:14 UTC 2022
|
PRIMARY | |||
|
RKU631JF4H
Created by
admin on Fri Dec 16 23:47:14 UTC 2022 , Edited by admin on Fri Dec 16 23:47:14 UTC 2022
|
PRIMARY | |||
|
2790
Created by
admin on Fri Dec 16 23:47:14 UTC 2022 , Edited by admin on Fri Dec 16 23:47:14 UTC 2022
|
PRIMARY |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
TARGET -> INHIBITOR |
| Related Record | Type | Details | ||
|---|---|---|---|---|
|
|
ACTIVE MOIETY |
