Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C12H17N5 |
| Molecular Weight | 231.2969 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC(C)(C)NC(NC1=CC=CN=C1)=NC#N
InChI
InChIKey=HKZNADVVGXKQDL-UHFFFAOYSA-N
InChI=1S/C12H17N5/c1-4-12(2,3)17-11(15-9-13)16-10-6-5-7-14-8-10/h5-8H,4H2,1-3H3,(H2,15,16,17)
| Molecular Formula | C12H17N5 |
| Molecular Weight | 231.2969 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 1 |
| Optical Activity | NONE |
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Pharmacological comparison of native mitochondrial K(ATP) channels with molecularly defined surface K(ATP) channels. | 2001 Feb |
|
| Fluorescence-based functional assay for sarcolemmal ATP-sensitive potassium channel activation in cultured neonatal rat ventricular myocytes. | 2001 Jul-Aug |
|
| Functional implication of spare ATP-sensitive K(+) channels in bladder smooth muscle cells. | 2001 Mar |
|
| Effects of K(ATP) channel openers, P-1075, pinacidil, and diazoxide, on energetics and contractile function in isolated rat hearts. | 2002 Apr |
|
| PNU-83757: a new agent for the treatment of erectile dysfunction. | 2002 Dec |
|
| The efficacy, safety and tolerability of intracavernous PNU-83757 for the treatment of erectile dysfunction. | 2002 Jun |
|
| KCO912: a potent and selective opener of ATP-dependent potassium (K(ATP)) channels which suppresses airways hyperreactivity at doses devoid of cardiovascular effects. | 2002 Mar |
|
| Sarcolemmal and mitochondrial effects of a KATP opener, P-1075, in "polarized" and "depolarized" Langendorff-perfused rat hearts. | 2003 Dec 3 |
|
| Cardioselective sulfonylthiourea HMR 1098 blocks mitochondrial uncoupling induced by a KATP channel opener, P-1075, in beating rat hearts. | 2003 Jul 14 |
|
| P1075 opens mitochondrial K(ATP) channels and generates reactive oxygen species resulting in cardioprotection of rabbit hearts. | 2003 Sep |
|
| Selective ATP-sensitive potassium channel openers: fact or fiction. | 2003 Sep |
|
| Interaction of a novel dihydropyridine K+ channel opener, A-312110, with recombinant sulphonylurea receptors and KATP channels: comparison with the cyanoguanidine P1075. | 2004 Apr |
|
| Lipids modulate ligand binding to sulphonylurea receptors. | 2005 Aug |
|
| Reduced effectiveness of HMR 1098 in blocking cardiac sarcolemmal K(ATP) channels during metabolic stress. | 2005 Oct |
|
| Characterization of K(ATP)-channels in rat basilar and middle cerebral arteries: studies of vasomotor responses and mRNA expression. | 2005 Oct 31 |
|
| Pharmacological characterization of urinary bladder smooth muscle contractility following partial bladder outlet obstruction in pigs. | 2006 Feb 17 |
|
| GSK3beta inhibition and K(ATP) channel opening mediate acute opioid-induced cardioprotection at reperfusion. | 2007 Jul |
|
| Three C-terminal residues from the sulphonylurea receptor contribute to the functional coupling between the K(ATP) channel subunits SUR2A and Kir6.2. | 2008 Jul 1 |
|
| Potassium fluxes, energy metabolism, and oxygenation in intact diabetic rat hearts under normal and stress conditions. | 2008 Oct |
|
| Substitution of the Walker A lysine by arginine in the nucleotide-binding domains of sulphonylurea receptor SUR2B: effects on ligand binding and channel activity. | 2010 Jun |
| Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 15:45:51 GMT 2023
by
admin
on
Fri Dec 15 15:45:51 GMT 2023
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| Record UNII |
RA77IZ6B2F
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| Record Status |
Validated (UNII)
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| Record Version |
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RA77IZ6B2F
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60559-98-0
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DTXSID60209335
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admin on Fri Dec 15 15:45:51 GMT 2023 , Edited by admin on Fri Dec 15 15:45:51 GMT 2023
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