Adenosine 5?-triphosphate-sensitive potassium ion (KATP) channel Kir6.1/Sur 2B

Approval Year

Substance Class	Protein
Protein Type	ION CHANNEL
Protein Sub Type	POTASSIUM CHANNEL
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	VPD2Z47JYQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Adenosine 5?-triphosphate-sensitive potassium ion (KATP) channel Kir6.1/Sur 2B

Common Name

English

ATP-binding cassette sub-family C member 9 Kir6.1/ATP-sensitive inward rectifier potassium channel 8 Sur 2B

Preferred Name

English

Kir6.1/Sur2B

Common Name

English

Kir6.1/Sur 2B K+ (KATP) channel

Common Name

English

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Code System

Code

Type

Description

UNIPROT

Q15842

PRIMARY

UNIPROT

O60706

PRIMARY

FDA UNII

VPD2Z47JYQ

PRIMARY

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Subunit 0

Subunit 1

Subunit 2

Subunit 3

Subunit 4

Subunit 5

Subunit 6

Subunit 7

Glycosylation Type

HUMAN

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Glycosylation Link Type	Site
N	1_9
N	1_280
N	1_326
N	1_330
N	1_333

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Related Record

Type

Details


					H6UIO70F5E

ZD-6169

ACTIVATOR -> TARGET

Comments:

Opens potassium channel. Test done in Guinea pigs bladder muscle. Inhibition of action potentials and phasic contractions of UBSM. The results suggest that activation of <1% of KATP channels is sufficient to inhibit significantly action potentials and the related phasic contractions.

Qualification:

K1/2

Amount:

47 NANOMOLAR (average)