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Details

Stereochemistry ACHIRAL
Molecular Formula C4H2O4.Fe
Molecular Weight 169.901
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 1
Charge 0

SHOW SMILES / InChI
Structure of FERROUS FUMARATE

SMILES

[Fe++].[O-]C(=O)\C=C\C([O-])=O

InChI

InChIKey=PMVSDNDAUGGCCE-TYYBGVCCSA-L
InChI=1S/C4H4O4.Fe/c5-3(6)1-2-4(7)8;/h1-2H,(H,5,6)(H,7,8);/q;+2/p-2/b2-1+;

HIDE SMILES / InChI
Molecular Formula Fe
Molecular Weight 55.845
Charge 2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C4H2O4
Molecular Weight 114.0563
Charge -2
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 1
Optical Activity NONE

Description
Curator's Comment: description was created based on several sources, including http://www.minapharm.com/Public/ProductDetails.aspx?ProductCode=FERRO_SANO&langParam=en

Iron(II) gluconate (also known as a ferrous gluconate) is used in the treatment of hypochromic anemia. The real problem of iron therapy is not the theoretical utilization of iron, or the reticulocyte response, or even the daily increase of hemoglobin. These are important only as they indicate the return of the patients' blood to normal in a reasonably short time without undue inconvenience. Most patients suffering from hypochromic anemia respond well to most forms of iron when administered in adequate dosage. For the patients who cannot tolerate the usual iron compounds, it is important to have a medication which is effective and which causes minimum disturbance. Ferrous gluconate is such a medicament.

Originator

Approval Year

1921
1467
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Palliative
Not Provided
504
Unknown

Approved Use

Unknown
Palliative
Not Provided
504
Unknown

Approved Use

Unknown
Primary
Approved
8429
Ferro Sanol Duodenal

Approved Use

Ferro Sanol is an iron substitute in case of latent or manifest iron deficiency with and without development of anaemia.
PubMed

PubMed

TitleDatePubMed
FERROUS IODIDE AS A SUBSTITUTE FOR VITAMIN A IN RATS.
1932 Jul 1
FERROUS IODIDE AND LINOLEIC ACID IN VITAMIN A DEFICIENCY. A REPLY TO CERTAIN CRITICISMS.
1932 Nov 11
THE ADMINISTRATION OF FERROUS IODIDE AND LINOLEIC ACID TO RATS DEPRIVED OF VITAMIN A.
1932 Sep 30
THE USE OF FERROUS GLUCONATE IN THE TREATMENT OF HYPOCHROMIC ANEMIA.
1937 Jul
[Ferrous lactate as an oral iron preparation for therapeutic use].
1954 Nov 27
Clinical appraisal of drugs with special reference to a new chelate hematinic.
1957 Jul 11
[FERROUS ASPARTATE IN THERAPY].
1964 Jan 1
[Historical notes on the therapy of depression].
1986 Nov 22
Determination of water in ferrous lactate by near infrared reflectance spectroscopy with a fibre-optic probe.
1997 Oct
Decreased treatment failure rates following duodenal release ferrous glycine sulfate in iron deficiency anemia associated with autoimmune gastritis and Helicobacter pylori gastritis.
2007
Reversal of multidrug resistance by magnetic Fe3O4 nanoparticle copolymerizating daunorubicin and 5-bromotetrandrine in xenograft nude-mice.
2009
Bioleaching of heavy metals from sewage sludge by indigenous iron-oxidizing microorganisms using ammonium ferrous sulfate and ferrous sulfate as energy sources: a comparative study.
2009 Nov 15
The effect of iron treatment on adhesion molecules in patients with iron deficiency anemia.
2010 Dec
Endothelial dysfunction and inflammation induced by iron oxide nanoparticle exposure: Risk factors for early atherosclerosis.
2011 Jun 10
Tolerability of different oral iron supplements: a systematic review.
2013 Apr
Effect of abomasal ferrous lactate infusion on phosphorus absorption in lactating dairy cows.
2013 Jul
A practical and successful desensitization protocol for immediate hypersensitivity reactions to iron salts.
2014
Synthesis of phosphabenzenes by an iron-catalyzed [2+2+2] cycloaddition reaction of diynes with phosphaalkynes.
2015 Jun 22
Reactivity enhancement of iron sulfide nanoparticles stabilized by sodium alginate: Taking Cr (VI) removal as an example.
2017 Jul 5
Atomic Layer Deposition of Iron Sulfide and Its Application as a Catalyst in the Hydrogenation of Azobenzenes.
2017 Mar 13
Continuous sulfidogenic wastewater treatment with iron sulfide sludge oxidation and recycle.
2017 May 1
Patents

Patents

CN105565963
36
US20020127665
36
US2009028810
36
US20150202224
36
US2877253
36
US3091626
36
US5534268
36
US6407138
36
US8080520
36
US8802114
36

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:23:19 GMT 2023
Edited
by admin
on Fri Dec 15 15:23:19 GMT 2023
Record UNII
R5L488RY0Q
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
FERROUS FUMARATE
EP   FCC   II   INCI   JAN   MART.   MI   ORANGE BOOK   USP   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
GALFER
Common Name English
FERROUS FUMARATE COMPONENT OF NORQUEST FE
Common Name English
NORQUEST FE COMPONENT FERROUS FUMARATE
Common Name English
IRCON
Common Name English
HEFEROL
Common Name English
IRON FUMARATE
Systematic Name English
FUMARIC ACID, IRON(2+) SALT (1:1)
Common Name English
CPIRON
Common Name English
TOLERON
Common Name English
LO MINASTRIN FE COMPONENT FERROUS FUMARATE
Brand Name English
FERROUS FUMARATE [INCI]
Common Name English
2-BUTENEDIOIC ACID (E)-, IRON(2+) SALT (1:1)
Common Name English
TOLFERAIN
Common Name English
ORGASAL
Common Name English
METERFER
Common Name English
FERROUS FUMARATE [USP MONOGRAPH]
Common Name English
FERROUS FUMARATE [II]
Common Name English
IRON (AS FERROUS FUMARATE)
VANDF  
Common Name English
TOLIFER
Common Name English
IRON(II) FUMARATE
Systematic Name English
MINASTRIN 24 FE COMPONENT FERROUS FUMARATE
Brand Name English
FERROUS FUMARATE [VANDF]
Common Name English
FERROUS FUMARATE [EP MONOGRAPH]
Common Name English
HEMOTON
Common Name English
FERROUS FUMARATE [MART.]
Common Name English
FERROUS FUMARATE [WHO-IP]
Common Name English
2-BUTENEDIOIC ACID (2E)-, IRON(2+) SALT (1:1)
Common Name English
FERROSI FUMARAS [WHO-IP LATIN]
Common Name English
ERCOFERRO
Common Name English
FERROUS FUMARATE [JAN]
Common Name English
FERROUS FUMARATE [MI]
Common Name English
2-BUTENEDIOIC ACID, (E)-, IRON(2+) SALT
Common Name English
FERROUS FUMARATE [ORANGE BOOK]
Common Name English
IRON (AS FUMARATE)
Common Name English
FEOSTAT
Common Name English
IRON (AS FERROUS FUMARATE) [VANDF]
Common Name English
ERCO-FER
Common Name English
PALAFER
Common Name English
Ferrous fumarate [WHO-DD]
Common Name English
FERROFUME
Common Name English
FERROUS FUMARATE [FCC]
Common Name English
Classification Tree Code System Code
WHO-ATC B03AD02
Created by admin on Fri Dec 15 15:23:19 GMT 2023 , Edited by admin on Fri Dec 15 15:23:19 GMT 2023
WHO-ATC B03AA02
Created by admin on Fri Dec 15 15:23:19 GMT 2023 , Edited by admin on Fri Dec 15 15:23:19 GMT 2023
CFR 21 CFR 184.1307D
Created by admin on Fri Dec 15 15:23:19 GMT 2023 , Edited by admin on Fri Dec 15 15:23:19 GMT 2023
WHO-VATC QB03AA02
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
WHO-VATC QB03AD02
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
CFR 21 CFR 172.350
Created by admin on Fri Dec 15 15:23:19 GMT 2023 , Edited by admin on Fri Dec 15 15:23:19 GMT 2023
Code System Code Type Description
ChEMBL
CHEMBL1200640
Created by admin on Fri Dec 15 15:23:19 GMT 2023 , Edited by admin on Fri Dec 15 15:23:19 GMT 2023
PRIMARY
ECHA (EC/EINECS)
205-447-7
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
DRUG BANK
DB14491
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PRIMARY
CAS
141-01-5
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PRIMARY
RXCUI
24941
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
DAILYMED
R5L488RY0Q
Created by admin on Fri Dec 15 15:23:19 GMT 2023 , Edited by admin on Fri Dec 15 15:23:19 GMT 2023
PRIMARY
NCI_THESAURUS
C61763
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
MESH
C031621
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
NCI_THESAURUS
C1505
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
CONCEPT Dietary Supplement
WHO INTERNATIONAL PHARMACOPEIA
FERROUS FUMARATE
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY Description: A fine, reddish orange or reddish brown powder.Solubility: Slightly soluble in water; very slightly soluble in ethanol (~750 g/l) TS.Category: Iron supplement.Storage: Ferrous fumarate should be kept in a well-closed container.Definition: Ferrous fumarate contains not less than 93.0% and not more than 101.0% of C4H2FeO4, calculated with reference to the dried substance.
RXCUI
486120
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
ALTERNATIVE
MERCK INDEX
m5343
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY Merck Index
EVMPD
SUB13865MIG
Created by admin on Fri Dec 15 15:23:19 GMT 2023 , Edited by admin on Fri Dec 15 15:23:19 GMT 2023
PRIMARY
FDA UNII
R5L488RY0Q
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
EPA CompTox
DTXSID7047148
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
PUBCHEM
6433164
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
WIKIPEDIA
IRON(II) FUMARATE
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
SMS_ID
100000090445
Created by admin on Fri Dec 15 15:23:20 GMT 2023 , Edited by admin on Fri Dec 15 15:23:20 GMT 2023
PRIMARY
DRUG CENTRAL
4261
Created by admin on Fri Dec 15 15:23:19 GMT 2023 , Edited by admin on Fri Dec 15 15:23:19 GMT 2023
PRIMARY
Related Record Type Details
Structure of Fumaric acid
PARENT -> SALT/SOLVATE
Structure of FERROUS CATION
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of FERROUS CATION
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