DIMECROTIC ACID

Details

Stereochemistry	ACHIRAL
Molecular Formula	C12H14O4
Molecular Weight	222.2372
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC=C(\C(C)=C/C(O)=O)C(OC)=C1

InChI

InChIKey=VNLOISSPTMDCIF-VURMDHGXSA-N

InChI=1S/C12H14O4/c1-8(6-12(13)14)10-5-4-9(15-2)7-11(10)16-3/h4-7H,1-3H3,(H,13,14)/b8-6-

HIDE SMILES / InChI

Molecular Formula	C12H14O4
Molecular Weight	222.2372
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Description
Sources: DOI: 10.1002/14356007.a12_143 | http://medic.vn/2013/12/hepadial | http://sante.journaldesfemmes.com/medicaments/hepadial-50-mg/medicament-68842670

Dimecrotic acid is a choleretic agent with spasmolytic properties. It is obtained by reaction of resorcinol with acetoacetate to give 4-methyl-7-hydroxycoumarin. It is indicated for the treatment of hepato-digestive insufficiency and its manifestations. It shouldn’t be used in case of blockage of bile ducts, severe liver failure and severe renal impairment. Diarrhea may be associated with high doses of dimecrotic acid.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Dyspepsia 11 Sources: http://sante.journaldesfemmes.com/medicaments/hepadial-50-mg/medicament-68842670	Palliative		Approved 8583	Hepadial Approved Use Indicated for the symptomatic treatment of dyspepsia, associated with functional abdominal pain

PubMed

Title	Date	PubMed
Molecular search of new active drugs against Toxoplasma gondii.	1999	10408126

Patents

Sample Use Guides

In Vivo Use Guide

50 mg three times a day before meals

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:31:42 GMT 2025` Edited by `admin` on `Mon Mar 31 18:31:42 GMT 2025`
Record UNII	R46Y1C0ZR2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MOLNIA

Preferred Name

English

DIMECROTIC ACID

Official Name

English

Dimecrotic acid [WHO-DD]

Common Name

English

dimecrotic acid [INN]

Common Name

English

DIMECROTATE

Common Name

English

DIMECROTIC ACID [MI]

Common Name

English

2,4-DIMETHOXY-.BETA.-METHYLCINNAMIC ACID

Systematic Name

English

DIMECROTIC ACID [MART.]

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C1937