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Details

Stereochemistry ABSOLUTE
Molecular Formula C25H30F2N2O4
Molecular Weight 460.5135
Optical Activity UNSPECIFIED
Defined Stereocenters 1 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ABEDITEROL

SMILES

O[C@@H](CNCCCCCCOCC(F)(F)C1=CC=CC=C1)C2=CC=C(O)C3=C2C=CC(=O)N3

InChI

InChIKey=SFYAXIFVXBKRPK-QFIPXVFZSA-N
InChI=1S/C25H30F2N2O4/c26-25(27,18-8-4-3-5-9-18)17-33-15-7-2-1-6-14-28-16-22(31)19-10-12-21(30)24-20(19)11-13-23(32)29-24/h3-5,8-13,22,28,30-31H,1-2,6-7,14-17H2,(H,29,32)/t22-/m0/s1

HIDE SMILES / InChI

Molecular Formula C25H30F2N2O4
Molecular Weight 460.5135
Charge 0
Count
Stereochemistry ABSOLUTE
Additional Stereochemistry No
Defined Stereocenters 1 / 1
E/Z Centers 0
Optical Activity UNSPECIFIED

Abediterol, a fast and long-acting β2-adrenoceptor agonist (LABA), is being developed by AstraZeneca, for the treatment of asthma and chronic obstructive pulmonary disease. The investigational drug is a long-acting beta2-agonist (LABA) that has a bronchodilator effect, relaxing the muscles around the airways. It is currently under development and is in Phase II clinical trials.

Approval Year

PubMed

PubMed

TitleDatePubMed
Abediterol, a novel long-acting β2-agonist: bronchodilation, safety, tolerability and pharmacokinetic results from a single-dose, dose-ranging, active-comparator study in patients with COPD.
2016 Jul 20
Patents

Patents

Sample Use Guides

The first Phase 2 study of abediterol as a COPD treatment was completed in 2012. It evaluate four single doses of inhaled abediterol at 0.625, 2.5, 5 or 10 ug. Results showed that all doses significantly improved bronchodilation when compared to a placebo. Doses of 2.5, 5, and 10 ug also showed improvements when compared to the active comparator.
Route of Administration: Respiratory
The potency and onset of action that abediterol shows in isolated human bronchi (EC(50) = 1.9 ± 0.4 nM; t½ onset = 7-10 min)
Substance Class Chemical
Created
by admin
on Fri Dec 15 19:16:59 UTC 2023
Edited
by admin
on Fri Dec 15 19:16:59 UTC 2023
Record UNII
QXA167CM6F
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ABEDITEROL
INN   USAN   WHO-DD  
USAN   INN  
Official Name English
abediterol [INN]
Common Name English
ABEDITEROL [USAN]
Common Name English
5-((1R)-2-((6-(2,2-DIFLUORO-2-PHENYLETHOXY)HEXYL)AMINO)-1-HYDROXYETHYL)-8-HYDROXYQUINOLIN-2(1H)-ONE
Systematic Name English
LAS100977
Code English
LAS-100977
Code English
2(1H)-QUINOLINONE, 5-((1R)-2-((6-(2,2-DIFLUORO-2-PHENYLETHOXY)HEXYL)AMINO)-1-HYDROXYETHYL)-8-HYDROXY-
Systematic Name English
Abediterol [WHO-DD]
Common Name English
Classification Tree Code System Code
NCI_THESAURUS C48149
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
Code System Code Type Description
WIKIPEDIA
ABEDITEROL
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
EPA CompTox
DTXSID60238605
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
FDA UNII
QXA167CM6F
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
CHEBI
142077
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
CAS
915133-65-2
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
PUBCHEM
11962616
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
DRUG BANK
DB12100
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
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NCI_THESAURUS
C132738
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
USAN
ZZ-25
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
SMS_ID
300000024924
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
ChEMBL
CHEMBL3039530
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
INN
9406
Created by admin on Fri Dec 15 19:16:59 UTC 2023 , Edited by admin on Fri Dec 15 19:16:59 UTC 2023
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SHORT-ACTING
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY