Details
Stereochemistry | RACEMIC |
Molecular Formula | C23H40N2O3 |
Molecular Weight | 392.5753 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 2 |
SHOW SMILES / InChI
SMILES
CC[N+](C)(CC)CCOCCOC(=O)C(C1=CC=CC=C1)[N+]2(C)CCCCC2
InChI
InChIKey=UQVDQHWKXJHFEN-UHFFFAOYSA-N
InChI=1S/C23H40N2O3/c1-5-24(3,6-2)17-18-27-19-20-28-23(26)22(21-13-9-7-10-14-21)25(4)15-11-8-12-16-25/h7,9-10,13-14,22H,5-6,8,11-12,15-20H2,1-4H3/q+2
Molecular Formula | C23H40N2O3 |
Molecular Weight | 392.5753 |
Charge | 2 |
Count |
|
Stereochemistry | MIXED |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
Piprocurarium is a curarimimetic. It is antagonized by neostigmine. Piprocurarium is strongly vagolytic, producing tachicardia. Its duration of action is shorter than that of d-tubocurare and longer than that of succinylcholine. Piprocurarium is not hypotensive, is only slightly histaminogenic, is nonirritating to the veins, and can be mixed with all the anesthetic drugs. Piprocurarium has been offered for clinical trial as a brief-acting, nondepolarizing neuromuscular blocking drug. The drug appears to be anything but short acting. A persistent tachycardia and elevation in systolic and diastolic pressure invariably follows its intravenous injection. Alarming electrocardiographic changes occur, characterized by AV dissociation, depression of the ST segment, supraventricular tachycardia and, at times, inversion of the T waves. In view of these circulatory effects, it is doubtful that the drug will be useful clinically.
Approval Year
PubMed
Title | Date | PubMed |
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[Clinical use of a short-acting curarimimetic agent: Brevicurarine (LD-2480)]. | 1961 Jul-Aug |
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[Use of a short-acting curare, LD-2480 (Piprocurarium or Brevicurarine)]. | 1962 Jan-Feb |
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[Piprocurarium (iodide) and gallamine (triiodoethylate). Precise comparative clinical trial]. | 1962 Jan-Feb |
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CLINICAL USEFULNESS OF PIPROCURARIUM AS A MUSCLE RELAXANT. | 1964 May-Jun |
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 08:19:41 UTC 2023
by
admin
on
Sat Dec 16 08:19:41 UTC 2023
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Record UNII |
QM6F1222QU
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Record Status |
Validated (UNII)
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Record Version |
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QM6F1222QU
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24419
Created by
admin on Sat Dec 16 08:19:41 UTC 2023 , Edited by admin on Sat Dec 16 08:19:41 UTC 2023
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744949-11-9
Created by
admin on Sat Dec 16 08:19:41 UTC 2023 , Edited by admin on Sat Dec 16 08:19:41 UTC 2023
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SALT/SOLVATE -> PARENT |
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ACTIVE MOIETY |