Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H8O3S |
| Molecular Weight | 172.203 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
Cc1ccc(cc1)S(=O)(=O)O
InChI
InChIKey=JOXIMZWYDAKGHI-UHFFFAOYSA-N
InChI=1S/C7H8O3S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H,8,9,10)
| Molecular Formula | C7H8O3S |
| Molecular Weight | 172.203 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
p-Toluenesulfonic acid (PTSA) is an organic compound with the formula CH3C6H4SO3H. An aromatic sulfonic acid, often used as a strong acid catalyst. p-Toluenesulfonic acid monohydrate has been used as a reducing agent for the reductive amination of ketones and aldehydes. In the presence of p-Toluenesulfonic acid monohydrate novel deazaflavin-cholestane hybrid compounds have been synthesized in a condensation reaction. 2-Phenylethyl alpha-glucoside has also been synthesized in the presence of p-Toluenesulfonic acid monohydrate. p-toluenesulfonic acid esters, are a common class of reagents used in the pharmaceutical
industry as alkylating agents, catalysts, and in purification steps of the chemical synthesis of a drug substance.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Immobilization of glucose oxidase in polypyrrole/polytetrahydrofuran graft copolymers. | 2002 Apr 8 |
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| Anion effects on the recognition of ion pairs by calix[4]arene-based heteroditopic receptors. | 2002 Aug 23 |
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| Tandem Pummerer/Mannich cyclization cascade of alpha-sulfinylamides as a method to prepare aza-heterocycles. | 2002 Aug 23 |
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| Suplatast tosilate inhibits thymus- and activation-regulated chemokine production by antigen-specific human Th2 cells. | 2002 Dec |
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| [Unexpected formation of an estrone derivative from androsta-1,4-diene-3,17-dione]. | 2002 Dec |
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| Bimetallic carbonyl thiolates as functional models for Fe-only hydrogenases. | 2002 Dec 16 |
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| Application of micellar electrokinetic chromatography to the determination of sultamicillin in oral pharmaceutical preparations. | 2002 Dec 6 |
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| Silver(I) oxide mediated highly selective monotosylation of symmetrical diols. Application to the synthesis of polysubstituted cyclic ethers. | 2002 Jul 11 |
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| Modification of the swern oxidation: use of a recyclable, polystyrene bound sulfoxide. | 2002 Jul 22 |
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| Syntheses, derivatives, solubility, and interfacial properties of 2-methyl-2-polyfluoroalkenyloxymethyl-1,3-propanediols: potential building blocks for syntheses of amphiphatic macromolecules. | 2002 Mar 8 |
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| Electrochemical solid-phase microextraction of anions and cations using polypyrrole coatings and an integrated three-electrode device. | 2002 May |
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| Synthesis and evaluation of 4-bromo-1-(3-[18F]fluoropropyl)-2-nitroimidazole with a low energy LUMO orbital designed as brain hypoxia-targeting imaging agent. | 2002 May |
|
| Novel Brønsted acidic ionic liquids and their use as dual solvent-catalysts. | 2002 May 29 |
|
| Acid-catalyzed formation of hexahomooxacalix[3]arenes. | 2002 May 3 |
|
| A fully automated one pot synthesis of 9-(4-[18F]fluoro-3-hydroxymethylbutyl) guanine for gene therapy studies. | 2002 Nov |
|
| Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging. | 2002 Nov 7 |
|
| Importance of the nature of anions in lysozyme crystallisation correlated with protein net charge variation. | 2002 Oct |
|
| Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles. | 2002 Sep |
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| Synthesis and anticonvulsant activity of some new dioxolane derivatives. | 2003 |
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| Novel oxidative alpha-tosyloxylation of alcohols with iodosylbenzene and p-toluenesulfonic acid and its synthetic use for direct preparation of heteroaromatics. | 2003 Aug 8 |
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| Synthesis, structure, and screening of estrogenic and antiestrogenic activity of new 3,17-substituted-16,17-seco-estratriene derivatives. | 2003 Dec |
|
| Molecular recognition of alkylammonium contact ion-pairs using a ditopic receptor. | 2003 Dec 12 |
|
| Solid-state structure dependence of the molecular distortion and spectroscopic properties of the Cu(I) bis(2,9-dimethyl-1,10-phenanthroline) ion. | 2003 Dec 29 |
|
| A complete family of isostructural cluster compounds with cubane-like M(3)S(4)M' cores (M = Mo, W; M' = Ni, Pd, Pt): comparative crystallography and electrochemistry. | 2003 Feb 24 |
|
| Antineoplastic agents 500. Narcistatin. | 2003 Jan |
|
| Oxidative addition of aryl tosylates to palladium(0) and coupling of unactivated aryl tosylates at room temperature. | 2003 Jul 23 |
|
| Reaction of imidazole with toluene-4-sulfonate salts of substituted phenyl N-methylpyridinium-4-carboxylate esters: special base catalysis by imidazole. | 2003 Jun 7 |
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| Phasing power at the K absorption edge of organic arsenic. | 2003 May |
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| Effects of suplatast tosilate on allergic eosinophilic airway inflammation in patients with mild asthma. | 2003 May |
|
| Antibacterial characteristics of newly developed amphiphilic lipids and DNA-lipid complexes against bacteria. | 2003 May 1 |
|
| A study on the conversion of indanones into carbostyrils. | 2003 May 15 |
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| Chirality control in 2,2'-biphosphole ligand leading to enantiopure Pd complex. | 2003 May 21 |
|
| An additional regulator, TsaQ, is involved with TsaR in regulation of transport during the degradation of p-toluenesulfonate in Comamonas testosteroni T-2. | 2003 Nov |
|
| Cytotoxic activity of tropolones against human oral tumor cell lines. | 2003 Nov-Dec |
|
| [Analysis of the anaerobic microbial community capable of degrading p-toluene sulphonate]. | 2003 Nov-Dec |
|
| Generating diverse skeletons of small molecules combinatorially. | 2003 Oct 24 |
|
| Convenient preparation of L-arabino-hexos-5-ulose derivatives from lactose. | 2003 Oct 31 |
|
| A novel synthesis of acyclonucleosides via allylation of 3-[1-(phenylhydrazono)-L-threo-2,3,4-trihydroxybut-1-yl]quinoxalin-2(1H)one. | 2003 Oct 31 |
|
| Thiyl radical reaction with thymine: absolute rate constant for hydrogen abstraction and comparison to benzylic C-H bonds. | 2003 Sep |
|
| Probing ionic association on metal oxide clusters by pulsed field gradient NMR spectroscopy: the example of Sn12-oxo clusters. | 2004 Apr 2 |
|
| Cyclodextrin complexation of a stilbene and the self-assembly of a simple molecular device. | 2004 Feb 7 |
|
| Synthesis and cytotoxicity of 9-(2-deoxy-2-alkyldithio-beta-D-arabinofuranosyl)purine nucleosides which are stable precursors to potential mechanistic probes of ribonucleotide reductases. | 2004 Jan 7 |
|
| Solid-phase synthesis of a library of hydroxyproline derivatives. | 2004 Jan-Feb |
|
| Conjugation of amino-containing drugs to polysaccharides by tosylation: amphotericin B-arabinogalactan conjugates. | 2004 Jul |
|
| Raman spectroscopy of benzenesulfonic and 4-toluenesulfonic acids dissolved in dimethylsulfoxide. | 2004 Jun |
|
| Synthesis of 3alpha,7alpha,14alpha-trihydroxy-5beta-cholan-24-oic acid: a potential primary bile acid in vertebrates. | 2004 Mar |
|
| Chiral synthesis of (2S,3S)-2-(2-morpholin-2-yl-2-phenylmethoxy)phenol. | 2004 Mar |
|
| Application of ionic liquid halide nucleophilicity for the cleavage of ethers: a green protocol for the regeneration of phenols from ethers. | 2004 May 14 |
|
| Synthesis of the new, cubane-like W3S4Co cluster core. Completion of the homologous series [(eta5-Cp')3M3S4Co(CO)] (M = Cr, Mo, W). | 2004 May 31 |
|
| Intercalation behavior and tensile strength of DNA-lipid films for the dental application. | 2004 Nov |
Patents
| Substance Class |
Chemical
Created
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admin
on
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Sat Jun 26 10:15:45 UTC 2021
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on
Sat Jun 26 10:15:45 UTC 2021
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| Record UNII |
QGV5ZG5741
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| Record Status |
Validated (UNII)
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EPA PESTICIDE CODE |
79058
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104-15-4
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6101
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203-180-0
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104-15-4
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M10962
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DB03120
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P-TOLUENESULFONIC ACID
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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