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Details

Stereochemistry ACHIRAL
Molecular Formula C7H8O3S
Molecular Weight 172.202
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of P-TOLUENESULFONIC ACID

SMILES

CC1=CC=C(C=C1)S(O)(=O)=O

InChI

InChIKey=JOXIMZWYDAKGHI-UHFFFAOYSA-N
InChI=1S/C7H8O3S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H,8,9,10)

HIDE SMILES / InChI

Molecular Formula C7H8O3S
Molecular Weight 172.202
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

p-Toluenesulfonic acid (PTSA) is an organic compound with the formula CH3C6H4SO3H. An aromatic sulfonic acid, often used as a strong acid catalyst. p-Toluenesulfonic acid monohydrate has been used as a reducing agent for the reductive amination of ketones and aldehydes. In the presence of p-Toluenesulfonic acid monohydrate novel deazaflavin-cholestane hybrid compounds have been synthesized in a condensation reaction. 2-Phenylethyl alpha-glucoside has also been synthesized in the presence of p-Toluenesulfonic acid monohydrate. p-toluenesulfonic acid esters, are a common class of reagents used in the pharmaceutical industry as alkylating agents, catalysts, and in purification steps of the chemical synthesis of a drug substance.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
PubMed

PubMed

TitleDatePubMed
Preparation of 1,2-O-isopropylidene derivatives of alpha-D-galactoseptanose, beta-L-altroseptanose, and 3-O-methyl-alpha-D-guloseptanose.
2001 Aug 23
Anion binding with two polyammonium macrocycles of different dimensionality.
2001 Aug 27
Anion allosteric effect in the recognition of tetramethylammonium salts by calix[4]arene cone conformers.
2001 Dec 14
[7alpha-18F]fluoro-17alpha-methyl-5alpha-dihydrotestosterone: a ligand for androgen receptor-mediated imaging of prostate cancer.
2001 Jan
[Cytokine production by peripheral blood mononuclear cells in bronchial asthma treated with suplatast tosilate].
2001 Jun
Modification of eosinophil function by suplatast tosilate (IPD), a novel anti-allergic drug.
2001 Nov
Microwave induced synthesis of ribonucleosides on solid support.
2002
Exclusive and complete introduction of amino groups and their N-sulfo and N-carboxymethyl groups into the 6-position of cellulose without the use of protecting groups.
2002 Aug 16
Anion effects on the recognition of ion pairs by calix[4]arene-based heteroditopic receptors.
2002 Aug 23
Synthesis and antiviral activity of novel exomethylene cyclopropyl pyrimidine nucleosides.
2002 Dec
Application of micellar electrokinetic chromatography to the determination of sultamicillin in oral pharmaceutical preparations.
2002 Dec 6
Tetra-N-confused cyclohexapyrrole: the unusual product formed by condensation of 3,3'-dipyrromethane with tripyrrin-aldehyde.
2002 Jul 12
Acid catalyzed transesterification as a route to poly(3-hydroxybutyrate-co-epsilon-caprolactone) copolymers from their homopolymers.
2002 Jul-Aug
Metal ion-dependent molecular inclusion chemistry: inclusion of aromatic anions by coordinated 1,4,7,10-tetrakis((S)-2-hydroxy-3-phenoxypropyl)-1,4,7,10-tetraazacyclododecane.
2002 Mar 11
Suppression of the Th2 pathway by suplatast tosilate in patients with perennial nasal allergies.
2002 Nov-Dec
Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles.
2002 Sep
Effects of suplatast tosilate on cytokine profile of bronchoalveolar cells in allergic inflammation of the lung.
2002 Sep
Deoxygenation of carbohydrates by thiol-catalysed radical-chain redox rearrangement of the derived benzylidene acetals.
2003 Apr 21
Reaction of imidazole with toluene-4-sulfonate salts of substituted phenyl N-methylpyridinium-4-carboxylate esters: special base catalysis by imidazole.
2003 Jun 7
An additional regulator, TsaQ, is involved with TsaR in regulation of transport during the degradation of p-toluenesulfonate in Comamonas testosteroni T-2.
2003 Nov
Thiyl radical reaction with thymine: absolute rate constant for hydrogen abstraction and comparison to benzylic C-H bonds.
2003 Sep
Ruthenium complexes with chiral tetradentate imino-sulfoxide ligands.
2003 Sep 22
Synthesis and cytotoxicity of 9-(2-deoxy-2-alkyldithio-beta-D-arabinofuranosyl)purine nucleosides which are stable precursors to potential mechanistic probes of ribonucleotide reductases.
2004 Jan 7
Raman spectroscopy of benzenesulfonic and 4-toluenesulfonic acids dissolved in dimethylsulfoxide.
2004 Jun
Application of ionic liquid halide nucleophilicity for the cleavage of ethers: a green protocol for the regeneration of phenols from ethers.
2004 May 14
Patents

Sample Use Guides

Rat: Acute toxicity at 2570 mg/kg
Route of Administration: Oral
p-Toluenesulfonic acid (PTSA) was added into the preheated SPO at different dosages (0.25-10% wt/wt) in presence of methanol to convert the FFA to FAME.
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:46:02 GMT 2023
Edited
by admin
on Fri Dec 15 15:46:02 GMT 2023
Record UNII
QGV5ZG5741
Record Status Validated (UNII)
Record Version
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Name Type Language
P-TOLUENESULFONIC ACID
MI  
Common Name English
BENZENESULFONIC ACID, 4-METHYL-
Common Name English
TOLUENE SULFONIC ACID
INCI  
INCI  
Official Name English
PTS-100
Common Name English
TIZANIDINE HYDROCHLORIDE IMPURITY I [EP IMPURITY]
Common Name English
TOLUENE SULFONIC ACID [INCI]
Common Name English
P-TOLUENESULFONIC ACID [MI]
Common Name English
ANASTROZOLE IMPURITY F [EP IMPURITY]
Common Name English
ELTESOL TSX
Brand Name English
C-250
Common Name English
SULTAMICILLIN IMPURITY B [EP IMPURITY]
Common Name English
NSC-2167
Code English
4-METHYLBENZENESULFONIC ACID
Systematic Name English
NACURE-1040
Common Name English
TOLUENESULFONIC ACID
Systematic Name English
ACTIVATOR-100T3
Common Name English
4-TOLUENESULFONIC ACID
Systematic Name English
NSC-167068
Code English
KC-1040
Common Name English
TSA-95
Common Name English
AD-3302W
Common Name English
TOLUENE-4-SULPHONIC ACID
Systematic Name English
DRYER-900
Common Name English
METHYLBENZENESULFONIC ACID
Systematic Name English
TOSIC ACID
Common Name English
CYZAC-4040
Common Name English
TAYCATOX-300
Common Name English
LISINOPRIL IMPURITY B [EP IMPURITY]
Common Name English
P-TOLUENESULFONIC ACID [EP IMPURITY]
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 79058
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
Code System Code Type Description
EPA CompTox
DTXSID0026701
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
PUBCHEM
6101
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
CHEBI
27849
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
ECHA (EC/EINECS)
203-180-0
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
FDA UNII
QGV5ZG5741
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
HSDB
2026
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
CAS
104-15-4
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
MERCK INDEX
m10962
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY Merck Index
DRUG BANK
DB03120
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
WIKIPEDIA
P-TOLUENESULFONIC ACID
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
SMS_ID
100000184188
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
NSC
2167
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
NSC
167068
Created by admin on Fri Dec 15 15:46:02 GMT 2023 , Edited by admin on Fri Dec 15 15:46:02 GMT 2023
PRIMARY
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