Details
| Stereochemistry | ACHIRAL |
| Molecular Formula | C7H8O3S |
| Molecular Weight | 172.202 |
| Optical Activity | NONE |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
CC1=CC=C(C=C1)S(O)(=O)=O
InChI
InChIKey=JOXIMZWYDAKGHI-UHFFFAOYSA-N
InChI=1S/C7H8O3S/c1-6-2-4-7(5-3-6)11(8,9)10/h2-5H,1H3,(H,8,9,10)
| Molecular Formula | C7H8O3S |
| Molecular Weight | 172.202 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ACHIRAL |
| Additional Stereochemistry | No |
| Defined Stereocenters | 0 / 0 |
| E/Z Centers | 0 |
| Optical Activity | NONE |
p-Toluenesulfonic acid (PTSA) is an organic compound with the formula CH3C6H4SO3H. An aromatic sulfonic acid, often used as a strong acid catalyst. p-Toluenesulfonic acid monohydrate has been used as a reducing agent for the reductive amination of ketones and aldehydes. In the presence of p-Toluenesulfonic acid monohydrate novel deazaflavin-cholestane hybrid compounds have been synthesized in a condensation reaction. 2-Phenylethyl alpha-glucoside has also been synthesized in the presence of p-Toluenesulfonic acid monohydrate. p-toluenesulfonic acid esters, are a common class of reagents used in the pharmaceutical
industry as alkylating agents, catalysts, and in purification steps of the chemical synthesis of a drug substance.
Approval Year
PubMed
| Title | Date | PubMed |
|---|---|---|
| Preparation of 1,2-O-isopropylidene derivatives of alpha-D-galactoseptanose, beta-L-altroseptanose, and 3-O-methyl-alpha-D-guloseptanose. | 2001 Aug 23 |
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| Anion allosteric effect in the recognition of tetramethylammonium salts by calix[4]arene cone conformers. | 2001 Dec 14 |
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| Synthesis of 1,2-unsaturated pyranosylphosphonate nucleosides from 3,4,6-tri-O-acetyl-D-glycal. | 2001 Jul |
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| Effects of suplatast tosilate on airway inflammation and airway hyperresponsiveness. | 2001 Jun |
|
| The C-H...O hydrogen bond in (dicyanomethyl)ammonium p-toluenesulfonate. | 2001 Jun |
|
| Heterobimetallic, cubane-like Mo(3)S(4)M' cluster cores containing the noble metals M' = Ru, Os, Rh, Ir. Unprecedented tri(mu-carbonyl) bridge between ruthenium atoms in [(eta(5)-Cp')(3)Mo(3)S(4)Ru)2(mu-CO)3]2+. | 2001 Jun 18 |
|
| Preparation and substitution chemistry of [Bu4N]2[W6Cl8(p-OSO2C6H4CH3)6]. A useful precursor for pseudohalide, acetate, and organometallic complexes containing the [W6Cl8](4+) core. | 2001 Sep 24 |
|
| Microwave induced synthesis of ribonucleosides on solid support. | 2002 |
|
| Immobilization of glucose oxidase in polypyrrole/polytetrahydrofuran graft copolymers. | 2002 Apr 8 |
|
| Exclusive and complete introduction of amino groups and their N-sulfo and N-carboxymethyl groups into the 6-position of cellulose without the use of protecting groups. | 2002 Aug 16 |
|
| Tandem Pummerer/Mannich cyclization cascade of alpha-sulfinylamides as a method to prepare aza-heterocycles. | 2002 Aug 23 |
|
| Synthesis and antiviral activity of novel exomethylene cyclopropyl pyrimidine nucleosides. | 2002 Dec |
|
| Application of micellar electrokinetic chromatography to the determination of sultamicillin in oral pharmaceutical preparations. | 2002 Dec 6 |
|
| Biosynthetic studies on the alpha-glucosidase inhibitor acarbose: the chemical synthesis of dTDP-4-amino-4,6-dideoxy-alpha-D-glucose. | 2002 Feb 18 |
|
| A comparative study of intermolecular interactions in the crystal structures of phenyl/phenyl end-capped oligoanilines. | 2002 Jul |
|
| Silver(I) oxide mediated highly selective monotosylation of symmetrical diols. Application to the synthesis of polysubstituted cyclic ethers. | 2002 Jul 11 |
|
| Tetra-N-confused cyclohexapyrrole: the unusual product formed by condensation of 3,3'-dipyrromethane with tripyrrin-aldehyde. | 2002 Jul 12 |
|
| Acid catalyzed transesterification as a route to poly(3-hydroxybutyrate-co-epsilon-caprolactone) copolymers from their homopolymers. | 2002 Jul-Aug |
|
| Sonochemical bromination of acetophenones using p-toluenesulfonic acid-N-bromosuccinimide. | 2002 Mar |
|
| Metal ion-dependent molecular inclusion chemistry: inclusion of aromatic anions by coordinated 1,4,7,10-tetrakis((S)-2-hydroxy-3-phenoxypropyl)-1,4,7,10-tetraazacyclododecane. | 2002 Mar 11 |
|
| S-alkylation and S-amination of methyl thioethers--derivatives of closo-[B(12)H(12)](2-). synthesis of a boronated phosphonate, gem-bisphosphonates, and dodecaborane-ortho-carborane oligomers. | 2002 Mar 20 |
|
| Syntheses, derivatives, solubility, and interfacial properties of 2-methyl-2-polyfluoroalkenyloxymethyl-1,3-propanediols: potential building blocks for syntheses of amphiphatic macromolecules. | 2002 Mar 8 |
|
| Electrochemical solid-phase microextraction of anions and cations using polypyrrole coatings and an integrated three-electrode device. | 2002 May |
|
| Novel Brønsted acidic ionic liquids and their use as dual solvent-catalysts. | 2002 May 29 |
|
| Acid-catalyzed formation of hexahomooxacalix[3]arenes. | 2002 May 3 |
|
| Synthesis and evaluation of no-carrier-added 8-cyclopentyl-3-(3-[(18)F]fluoropropyl)-1-propylxanthine ([(18)F]CPFPX): a potent and selective A(1)-adenosine receptor antagonist for in vivo imaging. | 2002 Nov 7 |
|
| Suppression of the Th2 pathway by suplatast tosilate in patients with perennial nasal allergies. | 2002 Nov-Dec |
|
| Sonolysis of surfactants in aqueous solutions: an accumulation of solute in the interfacial region of the cavitation bubbles. | 2002 Sep |
|
| Synthesis and anticonvulsant activity of some new dioxolane derivatives. | 2003 |
|
| Deoxygenation of carbohydrates by thiol-catalysed radical-chain redox rearrangement of the derived benzylidene acetals. | 2003 Apr 21 |
|
| Synthesis, structure, and screening of estrogenic and antiestrogenic activity of new 3,17-substituted-16,17-seco-estratriene derivatives. | 2003 Dec |
|
| Molecular recognition of alkylammonium contact ion-pairs using a ditopic receptor. | 2003 Dec 12 |
|
| Solid-state structure dependence of the molecular distortion and spectroscopic properties of the Cu(I) bis(2,9-dimethyl-1,10-phenanthroline) ion. | 2003 Dec 29 |
|
| [New photosensitizers of bacteriochlorin series for photodynamic cancer therapy]. | 2003 Mar-Apr |
|
| Effects of suplatast tosilate on allergic eosinophilic airway inflammation in patients with mild asthma. | 2003 May |
|
| Antibacterial characteristics of newly developed amphiphilic lipids and DNA-lipid complexes against bacteria. | 2003 May 1 |
|
| Chirality control in 2,2'-biphosphole ligand leading to enantiopure Pd complex. | 2003 May 21 |
|
| Cytotoxic activity of tropolones against human oral tumor cell lines. | 2003 Nov-Dec |
|
| A novel synthesis of acyclonucleosides via allylation of 3-[1-(phenylhydrazono)-L-threo-2,3,4-trihydroxybut-1-yl]quinoxalin-2(1H)one. | 2003 Oct 31 |
|
| Thiyl radical reaction with thymine: absolute rate constant for hydrogen abstraction and comparison to benzylic C-H bonds. | 2003 Sep |
|
| Ruthenium complexes with chiral tetradentate imino-sulfoxide ligands. | 2003 Sep 22 |
|
| Synthesis and cytotoxicity of 9-(2-deoxy-2-alkyldithio-beta-D-arabinofuranosyl)purine nucleosides which are stable precursors to potential mechanistic probes of ribonucleotide reductases. | 2004 Jan 7 |
|
| Solid-phase synthesis of a library of hydroxyproline derivatives. | 2004 Jan-Feb |
|
| Conjugation of amino-containing drugs to polysaccharides by tosylation: amphotericin B-arabinogalactan conjugates. | 2004 Jul |
|
| Raman spectroscopy of benzenesulfonic and 4-toluenesulfonic acids dissolved in dimethylsulfoxide. | 2004 Jun |
|
| Synthesis of 3alpha,7alpha,14alpha-trihydroxy-5beta-cholan-24-oic acid: a potential primary bile acid in vertebrates. | 2004 Mar |
|
| Crystal and molecular structures of new enantiopure quinuclidines. | 2004 Mar |
|
| Chiral synthesis of (2S,3S)-2-(2-morpholin-2-yl-2-phenylmethoxy)phenol. | 2004 Mar |
|
| Synthesis of the new, cubane-like W3S4Co cluster core. Completion of the homologous series [(eta5-Cp')3M3S4Co(CO)] (M = Cr, Mo, W). | 2004 May 31 |
|
| Intercalation behavior and tensile strength of DNA-lipid films for the dental application. | 2004 Nov |
Patents
| Substance Class |
Chemical
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admin
on
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Wed Jul 05 23:14:33 UTC 2023
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| Record UNII |
QGV5ZG5741
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| Record Status |
Validated (UNII)
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EPA PESTICIDE CODE |
79058
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DB03120
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P-TOLUENESULFONIC ACID
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100000184188
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PARENT -> CONSTITUENT ALWAYS PRESENT | |||
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SOLVATE->ANHYDROUS | |||
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SALT/SOLVATE -> PARENT |
| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
EP
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