PHENARSONE SULFOXYLATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C7H10AsNO6S
Molecular Weight	311.144
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC1=C(NCS(O)=O)C=C(C=C1)[As](O)(O)=O

InChI

InChIKey=MSEAHRGTAGLWGR-UHFFFAOYSA-N

InChI=1S/C7H10AsNO6S/c10-7-2-1-5(8(11,12)13)3-6(7)9-4-16(14)15/h1-3,9-10H,4H2,(H,14,15)(H2,11,12,13)

HIDE SMILES / InChI

Molecular Formula	C7H10AsNO6S
Molecular Weight	311.144
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/20323806 | Elks, J. (2014) The Dictionary of Drugs: Chemical Data, page 958, retrieved from: https://books.google.ru/books?id=0vXTBwAAQBAJ | https://www.ncbi.nlm.nih.gov/pubmed/18868767

Phenarsone sulfoxylate (Aldarsone), a pentavalent arsenical, is a condensation product of 3-amino-4 hydroxylphenylarsonic acid with sodium formaldehyde sulfoxylate. It is an antiamoebic agent. Aldarsone has a spirochetal power superior to that of tryparsamide. Aldarsone may be used in conjunction with artificial fever therapy and penicillin therapy to improve the results in symptomatic syphilis of the central nervous system (neurosyphilis).

Approval Year

PubMed

Title	Date	PubMed
The use of aldarsone in the treatment of neurosyphilis.	1946 Jun	20983623
ALDARSONE IN NEURO-SYPHILIS.	1946 Jun	20323806
Aldarsone and neurosyphilis.	1947 Sep	20260227
Aldarsone therapy in the treatment of general paresis.	1948 Aug	18888497
Aldarsone and bismuth combined in the treatment of neurosyphilis; report of 100 cases.	1948 Jul	18868767

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:51:09 GMT 2023` Edited by `admin` on `Fri Dec 15 18:51:09 GMT 2023`
Record UNII	QEG0T4K3VZ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

PHENARSONE SULFOXYLATE

Official Name

English

METHANESULFINIC ACID, 1-((5-ARSONOYL-2-HYDROXYPHENYL)AMINO)-

Systematic Name

English

1-((5-ARSONO-2-HYDROXYPHENYL)AMINO)METHANESULFINIC ACID

Systematic Name

English

phenarsone sulfoxylate [INN]

Common Name

English

Code System Code Type Description

FDA UNII

QEG0T4K3VZ