ISEGANAN

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67119872 | https://www.ncbi.nlm.nih.gov/pubmed/10348510 | https://www.ncbi.nlm.nih.gov/pubmed/22077420

IB-367, a synthetic analog of porcine protegrin, is an antimicrobial peptide. It reduces the local microflora densities and may improve clinical outcomes in patients at risk for the development of oral mucositis.

Originator

Approval Year

PubMed

Title	Date	PubMed
Effect of local application of the antimicrobial peptide IB-367 on the incidence and severity of oral mucositis in hamsters.	1999 May	10348510
IB-367, a protegrin peptide with in vitro and in vivo activities against the microflora associated with oral mucositis.	2000 Jul	10858334
Evaluation of pain associated with oral mucositis during the acute period after administration of high-dose chemotherapy.	2003 Jul 15	12872363
The antimicrobial effect of Iseganan HCl oral solution in patients receiving stomatotoxic chemotherapy: analysis from a multicenter, double-blind, placebo-controlled, randomized, phase III clinical trial.	2012 Mar	22077420

Sample Use Guides

In Vitro Use Guide

The minimal inhibitory concentrations (MICs) of iseganan (IB-367) ranged from 0.13 to 64 microgram/ml for gram-positive bacteria (Streptococcus mitis, Streptococcus sanguis, Streptococcus salivarius, and Staphylococcus aureus) and from 0.06 to 8 microgram/ml for gram-negative species (Klebsiella, Escherichia, and Pseudomonas). IB-367 exhibited rapid, microbicidal activity against both log- and stationary-phase cultures of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. At concentrations near the MICs for these two organisms (4 and 2 microgram/ml, respectively), IB-367 reduced viability by more than 3 logs in less than 16 min. Similarly, IB-367 effected a 4-log reduction of the endogenous microflora in pooled human saliva within 2 min at 250 microgram/ml, a concentration readily attained by local delivery.

Substance Class	Protein Created by `admin` on `Sat Dec 16 01:12:17 GMT 2023` Edited by `admin` on `Sat Dec 16 01:12:17 GMT 2023`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	Q9SAI36COS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

ISEGANAN

Official Name

English

ARG-GLY-GLY-LEU-CYS-TYR-CYS-ARG-GLY-ARG-PHE-CYS-VAL-CYS-VAL-GLY-ARG-NH2, CYCLIC (5-14, 7-12) DISULFIDE

Common Name

English

ISEGANAN [MI]

Common Name

English

L-ARGININAMIDE, L-ARGINYLGLYCYLGLYCYL-L-LEUCYL-L-CYSTEINYL-L-TYROSYL-L-CYSTEINYL-L-ARGINYLGLYCYL-L-ARGINYL-L-PHENYLALANYL-L-CYSTEINYL-L-VALYL-L-CYSTEINYL-L-VALYLGLYCYL-, CYCLIC (5->14), (7->12)-BIS(DISULFIDE)

Common Name

English

Iseganan [WHO-DD]

Common Name

English

iseganan [INN]

Common Name

English

IB-367

Code

English

Code System Code Type Description

FDA UNII

Q9SAI36COS