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Description

IB-367, a synthetic analog of porcine protegrin, is an antimicrobial peptide. It reduces the local microflora densities and may improve clinical outcomes in patients at risk for the development of oral mucositis.

Originator

Approval Year

Unknown
139594
PubMed

PubMed

TitleDatePubMed
IB-367, a protegrin peptide with in vitro and in vivo activities against the microflora associated with oral mucositis.
2000 Jul
Evaluation of pain associated with oral mucositis during the acute period after administration of high-dose chemotherapy.
2003 Jul 15

Sample Use Guides

In Vitro Use Guide
The minimal inhibitory concentrations (MICs) of iseganan (IB-367) ranged from 0.13 to 64 microgram/ml for gram-positive bacteria (Streptococcus mitis, Streptococcus sanguis, Streptococcus salivarius, and Staphylococcus aureus) and from 0.06 to 8 microgram/ml for gram-negative species (Klebsiella, Escherichia, and Pseudomonas). IB-367 exhibited rapid, microbicidal activity against both log- and stationary-phase cultures of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. At concentrations near the MICs for these two organisms (4 and 2 microgram/ml, respectively), IB-367 reduced viability by more than 3 logs in less than 16 min. Similarly, IB-367 effected a 4-log reduction of the endogenous microflora in pooled human saliva within 2 min at 250 microgram/ml, a concentration readily attained by local delivery.
Substance Class Protein
Created
by admin
on Sat Dec 16 05:11:00 GMT 2023
Edited
by admin
on Sat Dec 16 05:11:00 GMT 2023
Protein Sub Type
Sequence Type COMPLETE
Record UNII
HFF9H8LHP0
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ISEGANAN HYDROCHLORIDE ANHYDROUS
Common Name English
IB-367-03
Code English
L-ARGININAMIDE, L-ARGINYLGLYCYLGLYCYL-L-LEUCYL-L-CYSTEINYL-L-TYROSYL-L-CYSTEINYL-L-ARGINYLGLYCYL-L-ARGINYL-L-PHENYLALANYL-L-CYSTEINYL-L-VALYL-L-CYSTEINYL-L-VALYLGLYCYL-, CYCLIC (5->14), (7->12)-BIS(DISULFIDE), HYDROCHLORIDE
Common Name English
ARG-GLY-GLY-LEU-CYS-TYR-CYS-ARG-GLY-ARG-PHE-CYS-VAL-CYS-VAL-GLY-ARG-NH2, CYCLIC (5-14, 7-12) DISULFIDE HYDROCHLORIDE
Common Name English
ISEGANAN HYDROCHLORIDE [MI]
Common Name English
Iseganan hydrochloride [WHO-DD]
Common Name English
Code System Code Type Description
CAS
256475-21-5
Created by admin on Sat Dec 16 05:11:00 GMT 2023 , Edited by admin on Sat Dec 16 05:11:00 GMT 2023
PRIMARY
MERCK INDEX
m6420
Created by admin on Sat Dec 16 05:11:00 GMT 2023 , Edited by admin on Sat Dec 16 05:11:00 GMT 2023
PRIMARY Merck Index
FDA UNII
HFF9H8LHP0
Created by admin on Sat Dec 16 05:11:00 GMT 2023 , Edited by admin on Sat Dec 16 05:11:00 GMT 2023
PRIMARY
PUBCHEM
70691416
Created by admin on Sat Dec 16 05:11:00 GMT 2023 , Edited by admin on Sat Dec 16 05:11:00 GMT 2023
PRIMARY
EPA CompTox
DTXSID60180337
Created by admin on Sat Dec 16 05:11:00 GMT 2023 , Edited by admin on Sat Dec 16 05:11:00 GMT 2023
PRIMARY
From To
1_5 1_14
1_7 1_12
Related Record Type Details
ISEGANAN
STARTING MATERIAL -> INGREDIENT
Related Record Type Details
ISEGANAN
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:CALCULATED ANHYDROUS CHEMICAL
Molecular Formula CHEMICAL
NIH
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