ISEGANAN HYDROCHLORIDE ANHYDROUS

Investigational

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/67119872 | https://www.ncbi.nlm.nih.gov/pubmed/10348510 | https://www.ncbi.nlm.nih.gov/pubmed/22077420

IB-367, a synthetic analog of porcine protegrin, is an antimicrobial peptide. It reduces the local microflora densities and may improve clinical outcomes in patients at risk for the development of oral mucositis.

Originator

Approval Year

PubMed

Title	Date	PubMed
The antimicrobial effect of Iseganan HCl oral solution in patients receiving stomatotoxic chemotherapy: analysis from a multicenter, double-blind, placebo-controlled, randomized, phase III clinical trial.	2012-03	22077420
Evaluation of pain associated with oral mucositis during the acute period after administration of high-dose chemotherapy.	2003-07-15	12872363
IB-367, a protegrin peptide with in vitro and in vivo activities against the microflora associated with oral mucositis.	2000-07	10858334
Effect of local application of the antimicrobial peptide IB-367 on the incidence and severity of oral mucositis in hamsters.	1999-05	10348510

Sample Use Guides

In Vitro Use Guide

The minimal inhibitory concentrations (MICs) of iseganan (IB-367) ranged from 0.13 to 64 microgram/ml for gram-positive bacteria (Streptococcus mitis, Streptococcus sanguis, Streptococcus salivarius, and Staphylococcus aureus) and from 0.06 to 8 microgram/ml for gram-negative species (Klebsiella, Escherichia, and Pseudomonas). IB-367 exhibited rapid, microbicidal activity against both log- and stationary-phase cultures of methicillin-resistant Staphylococcus aureus and Pseudomonas aeruginosa. At concentrations near the MICs for these two organisms (4 and 2 microgram/ml, respectively), IB-367 reduced viability by more than 3 logs in less than 16 min. Similarly, IB-367 effected a 4-log reduction of the endogenous microflora in pooled human saliva within 2 min at 250 microgram/ml, a concentration readily attained by local delivery.

Substance Class	Protein Created by `admin` on `Mon Mar 31 21:26:55 GMT 2025` Edited by `admin` on `Mon Mar 31 21:26:55 GMT 2025`
Protein Sub Type
Sequence Type	COMPLETE
Record UNII	HFF9H8LHP0
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

IB-367-03

Preferred Name

English

ISEGANAN HYDROCHLORIDE ANHYDROUS

Common Name

English

L-ARGININAMIDE, L-ARGINYLGLYCYLGLYCYL-L-LEUCYL-L-CYSTEINYL-L-TYROSYL-L-CYSTEINYL-L-ARGINYLGLYCYL-L-ARGINYL-L-PHENYLALANYL-L-CYSTEINYL-L-VALYL-L-CYSTEINYL-L-VALYLGLYCYL-, CYCLIC (5->14), (7->12)-BIS(DISULFIDE), HYDROCHLORIDE

Common Name

English

ARG-GLY-GLY-LEU-CYS-TYR-CYS-ARG-GLY-ARG-PHE-CYS-VAL-CYS-VAL-GLY-ARG-NH2, CYCLIC (5-14, 7-12) DISULFIDE HYDROCHLORIDE

Common Name

English

ISEGANAN HYDROCHLORIDE [MI]

Common Name

English

Iseganan hydrochloride [WHO-DD]

Common Name

English

Code System Code Type Description

CAS

256475-21-5