U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Details

Stereochemistry ACHIRAL
Molecular Formula ClH
Molecular Weight 36.461
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of Hydrochloric acid

SMILES

Cl

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-N
InChI=1S/ClH/h1H

HIDE SMILES / InChI

Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
LACTATED RINGER'S

Approved Use

Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent.

Launch Date

1971
PubMed

PubMed

TitleDatePubMed
Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies.
1982 Oct
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.
1985 Aug
Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid.
1996 Feb
Risk of acute bronchospasm and bronchial hyperreactivity from inhaled acid aerosol in healthy subjects: randomized, double-blind controlled trial.
2004 Dec
Immunocytochemical characterization of rat brainstem neurons with vagal afferent input from the stomach challenged by acid or ammonia.
2004 Jan
JTE-607, a cytokine release blocker, attenuates acid aspiration-induced lung injury in rats.
2004 Mar 19
Effects of nitric oxide synthase inhibitor on acid aspiration-induced lung injury in rats.
2005
Esophageal ATP synthase and keratinocyte growth factor gene expression changes after acid and bile-induced mucosal damage.
2005 Apr
[Prophylactic effect of ambroxol on acute hydrochloric acid aspiration - induced lung injury].
2005 Jun
Independent contributions of hypothermia and acidosis to coagulopathy in swine.
2005 May
Pulmonary aspiration: new therapeutic approaches in the experimental model.
2005 Sep
Differential effects of intragastric acid and capsaicin on gastric emptying and afferent input to the rat spinal cord and brainstem.
2005 Sep 14
Molecular pharmacological approach to drug actions on the afferent and efferent fibres of the vagal nerve involved in gastric mucosal protection in rats.
2006 Dec
Vocal cord dysfunction concurrent with a nutcracker esophagus and the role of gastroesophageal reflux disease.
2006 Feb
Renal expression of the ammonia transporters, Rhbg and Rhcg, in response to chronic metabolic acidosis.
2006 Feb
[Effects of different modes of artificial ventilation on lung injury in dog model of acute respiratory distress syndrome].
2006 Jun
Effects of plastoquinones from the brown alga Sargassum micracanthum and a new chromene derivative converted from the plastoquinones on acute gastric lesions in rats.
2006 Jun
[Effects of lateral position and independent lung ventilation on unilateral acute lung injury in dogs].
2006 May
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.
2006 Oct 20
Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells.
2007 Feb
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].
2008 Jun
Hydrochloric acid aspiration increases right ventricular systolic pressure in rats.
2009 Apr
The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.
2009 Apr 1
Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury.
2009 Aug
Gastroprotective activity of alkaloid extract and 2-phenylquinoline obtained from the bark of Galipea longiflora Krause (Rutaceae).
2009 Jul 15
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].
2009 Jun
Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury.
2009 Mar
Bladder hyperactivity and increased excitability of bladder afferent neurons associated with reduced expression of Kv1.4 alpha-subunit in rats with cystitis.
2009 May
Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury.
2009 Nov
Animal study for airway inflammation triggered by gastroesophageal reflux.
2009 Nov 20
Influence of intra-oesophageal capsaicin instillation on heartburn induction and oesophageal sensitivity in man.
2009 Oct
Proton acts as a neurotransmitter for nicotine-induced adrenergic and calcitonin gene-related peptide-containing nerve-mediated vasodilation in the rat mesenteric artery.
2009 Sep
A novel external esophageal perfusion model for reflux-associated respiratory symptoms.
2010
Influence of chronic renal failure on acid secretion in isolated gastric mucosal cells from human biopsies.
2010
Prolonged hypoxemia and acidemia in anesthetized pigs: a model for research on extracorporeal organ support in an intensive care setting.
2010 Aug
Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury.
2010 Aug
Effect of intercalated cell-specific Rh C glycoprotein deletion on basal and metabolic acidosis-stimulated renal ammonia excretion.
2010 Aug
NHE4 is critical for the renal handling of ammonia in rodents.
2010 Jun
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.
2010 Nov
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.
2010 Nov
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury.
2010 Nov 29
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.
2010 Oct
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.
2010 Sep
The effect of tidal volume on systemic inflammation in Acid-induced lung injury.
2011
Inhibitory effect of rosiglitazone on the acid-induced intracellular generation of hydrogen peroxide in cultured feline esophageal epithelial cells.
2011 Feb
Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.
2011 May
JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide.
2013 Dec 15
Chemicals inducing acute irritant contact dermatitis mobilize intracellular calcium in human keratinocytes.
2013 Feb
The effect of thalidomide on ethanol-induced gastric mucosal damage in mice: involvement of inflammatory cytokines and nitric oxide.
2015 Jan 5
Patents
Substance Class Chemical
Created
by admin
on Fri Dec 15 15:43:39 GMT 2023
Edited
by admin
on Fri Dec 15 15:43:39 GMT 2023
Record UNII
QTT17582CB
Record Status Validated (UNII)
Record Version
  • Download
Related Record Type
Name Type Language
Hydrochloric acid
FCC   HSDB   II   INCI   MART.   MI   VANDF   WHO-DD   WHO-IP  
INCI  
Official Name English
BAUME HCL
Common Name English
E-507
Code English
HYDROCHLORIC ACID [MART.]
Common Name English
MURIATICUM ACIDUM [HPUS]
Common Name English
ACIDUM HYDROCHLORICUM [WHO-IP LATIN]
Common Name English
HYDROCHLORIC ACID [JAN]
Common Name English
ICON ETCH
Common Name English
HYDROCHLORIC ACID [WHO-IP]
Common Name English
HYDROCHLORIC ACID [VANDF]
Common Name English
INS-507
Code English
INS NO.507
Code English
HYDROCHLORIC ACID [FCC]
Common Name English
ANHYDROUS HYDROCHLORIC ACID
Common Name English
HYDROCHLORIC ACID [IARC]
Common Name English
HYDROGEN CHLORIDE
MI  
Systematic Name English
HYDROCHLORIC ACID [INCI]
Common Name English
MURIATIC ACID
Common Name English
HYDROCHLORIC ACID [MI]
Common Name English
HYDROGEN CHLORIDE [MI]
Common Name English
HYDROCHLORIC ACID [II]
Common Name English
HYDROCHLORIC ACID [HSDB]
Common Name English
NSC-77365
Code English
Hydrochloric acid [WHO-DD]
Common Name English
MURIATICUM ACIDUM
HPUS  
Common Name English
ENPLATE PO 236
Common Name English
Classification Tree Code System Code
EPA PESTICIDE CODE 45901
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
WHO-VATC QB05XA13
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
WHO-VATC QA09AB03
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
DSLD 1445 (Number of products:1)
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
JECFA EVALUATION INS-507
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
WHO-ATC A09AB03
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
WHO-ATC B05XA13
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
CODEX ALIMENTARIUS (GSFA) INS-507
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
FDA ORPHAN DRUG 98896
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
Code System Code Type Description
EVMPD
SUB50009
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
NCI_THESAURUS
C45678
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
CONCEPT Industrial Aid
WHO INTERNATIONAL PHARMACOPEIA
HYDROCHLORIC ACID
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY Description: A clear, colourless, fuming liquid; odour, pungent. Miscibility: Miscible with water. Category: Acidifying agent. Storage: Hydrochloric acid should be kept in a tightly closed container. Additional information: The fumes and odour disappear when the acid is diluted with 2 volumes of water. Mass density: .RHO.20 = about 1.18 g/mL. Requirement: Hydrochloric acid contains not less than 35.0% m/mand not more than the equivalent of 38.0% m/mof HCl.
DRUG CENTRAL
4568
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
RXCUI
5486
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY RxNorm
WIKIPEDIA
HYDROCHLORIC ACID
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
NCI_THESAURUS
C76716
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
EVMPD
SUB129759
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
ALTERNATIVE
PUBCHEM
313
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
CAS
7647-01-0
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
CHEBI
17883
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
MERCK INDEX
m6101
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY Merck Index
DAILYMED
QTT17582CB
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
ChEMBL
CHEMBL1231821
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
ECHA (EC/EINECS)
231-595-7
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
MERCK INDEX
m6088
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY Merck Index
MESH
D006851
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
EVMPD
SUB12513MIG
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
FDA UNII
QTT17582CB
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
DRUG BANK
DB13366
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
NSC
77365
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
SMS_ID
100000078724
Created by admin on Fri Dec 15 15:43:39 GMT 2023 , Edited by admin on Fri Dec 15 15:43:39 GMT 2023
PRIMARY
Related Record Type Details
SUB_CONCEPT->SUBSTANCE
Related Record Type Details
PARENT -> IMPURITY
Related Record Type Details
ACTIVE MOIETY