Hydrochloric acid

US Previously Marketed

First marketed in 1921

Details

Stereochemistry	ACHIRAL
Molecular Formula	ClH
Molecular Weight	36.461
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl

InChI

InChIKey=VEXZGXHMUGYJMC-UHFFFAOYSA-N

InChI=1S/ClH/h1H

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/mesh/68006851 | http://www.hmdb.ca/metabolites/HMDB0002306

HYDROCHLORIC ACID is formed by dissolving hydrogen chloride gas in water. It is a strong corrosive acid that is commonly used as a laboratory reagent. Also, it constitutes the majority of gastric acid, the human digestive fluid. Skin contact with HYDROCHLORIC ACID can cause redness, pain, and severe skin burns. It may cause severe burns to the eye and permanent eye damage.

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Surgical Blood Losses 2 Sources: https://www.accessdata.fda.gov/drugsatfda_docs/label/2011/016679s104,016682s105,016692s095,019367s026lbl.pdf	Primary		Approved 8429	LACTATED RINGER'S Approved Use Lactated Ringer’s and 5% Dextrose Injection, USP is indicated as a source of water, electrolytes and calories or as an alkalinizing agent. Launch Date 1971

PubMed

Title	Date	PubMed
Catabolism of haemoglobin-haptoglobin complexes in haemolytic uraemia-like syndromes of different etiologies.	1982 Oct	6218601
Gastric cytoprotection by pirenzepine in rats: evaluating method for cytoprotective activity by antisecretory agents.	1985 Aug	3865005
Role of oxygen-derived free radicals in indomethacin-induced gastric injury.	1991 Sep	1887894
Aging impairs afferent nerve function in rat intestine. Reduction of mesenteric hyperemia induced by intraduodenal capsaicin and acid.	1996 Feb	8601381
Molecular pharmacological approach to drug actions on the afferent and efferent fibres of the vagal nerve involved in gastric mucosal protection in rats.	2006 Dec	17139445
Vocal cord dysfunction concurrent with a nutcracker esophagus and the role of gastroesophageal reflux disease.	2006 Feb	16498863
[Effects of different modes of artificial ventilation on lung injury in dog model of acute respiratory distress syndrome].	2006 Jun	16784557
Effects of plastoquinones from the brown alga Sargassum micracanthum and a new chromene derivative converted from the plastoquinones on acute gastric lesions in rats.	2006 Jun	16755016
[Effects of lateral position and independent lung ventilation on unilateral acute lung injury in dogs].	2006 May	16759491
Zinc L-carnosine protects against mucosal injury in portal hypertensive gastropathy through induction of heat shock protein 72.	2006 Nov	16984587
Dietary acidification enhances phosphorus digestibility but decreases H+/K+-ATPase expression in rainbow trout.	2006 Oct	16985189
Expression of HSP72 in the gastric mucosa is regulated by gastric acid in rats-correlation of HSP72 expression with mucosal protection.	2006 Oct 20	16945336
Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions.	2007 Apr	17189318
Chronic metabolic acidosis alters osteoblast differentiation from human mesenchymal stem cells.	2007 Feb	17183249
Effect of prone position without PEEP on oxygenation and complacency in an experimental model.	2007 Jul-Aug	17627322
Spontaneous hypersensitivity in mesenteric afferent nerves of mice deficient in the sst2 subtype of somatostatin receptor.	2007 Jun 1	17363388
Beneficial effects of suplatast tosilate (IPD-1151T) in a rat cystitis model induced by intravesical hydrochloric acid.	2007 Oct	17714534
Bladder afferent sensitivity in wild-type and TRPV1 knockout mice.	2007 Sep 1	17627983
Muscarinic receptors involved in airway vascular leakage induced by experimental gastro-oesophageal reflux.	2008 Apr 23	18367213
Protective effects of S-methylisothiourea sulfate on different aspiration materials-induced lung injury in rats.	2008 Aug	18573544
Botulinum toxin type A inhibits sensory neuropeptide release in rat bladder models of acute injury and chronic inflammation.	2008 Feb	18184328
[Effects of recruitment maneuvers in prone position for pulmonary or extra-pulmonary acute respiratory distress syndrome on hemodynamics in dog].	2008 Jun	18549715
Fatal myocardial infarction after hydrochloric acid ingestion in a suicide attempt.	2008 Jun	18534312
Lung injury and recovery in a murine model of unilateral acid aspiration: functional, biochemical, and morphologic characterization.	2008 Jun	18497604
Effects of independent lung ventilation and lateral position on cytokine markers of inflammation after unilateral lung acid injury in dogs.	2008 Mar	18339021
Lactic acid increases aquaporin 4 expression on the cell membrane of cultured rat astrocytes.	2008 May	18406487
TRPV1 mediates cell death in rat synovial fibroblasts through calcium entry-dependent ROS production and mitochondrial depolarization.	2008 May 16	18331834
Adaptive HNE-Nrf2-HO-1 pathway against oxidative stress is associated with acute gastric mucosal lesions.	2008 Sep	18617559
Hydrochloric acid aspiration increases right ventricular systolic pressure in rats.	2009 Apr	19262391
The multimeric structure of polycystin-2 (TRPP2): structural-functional correlates of homo- and hetero-multimers with TRPC1.	2009 Apr 1	19193631
Permissive hypercapnia, instituted via reduction of pressure amplitude on pulmonary tissue protection during high frequency oscillatory ventilation, is not protective in a rat model of acid-induced lung injury.	2009 Aug	19644408
Hemodynamic effects of PEEP in a porcine model of HCl-induced mild acute lung injury.	2009 Feb	19094174
Impairment by 5-fluorouracil of the healing of gastric lesions in rats: effect of lafutidine, a histamine H2 receptor antagonist, mediated by capsaicin-sensitive afferent neurons.	2009 Jan	18594983
[The expression of substance P in airway mucosa of guinea pigs with repetitive esophageal stimulation by hydrochloric acid].	2009 Jun	19957777
Neither fibrin nor plasminogen activator inhibitor-1 deficiency protects lung function in a mouse model of acute lung injury.	2009 Mar	19060228
Neurally adjusted ventilatory assist decreases ventilator-induced lung injury and non-pulmonary organ dysfunction in rabbits with acute lung injury.	2009 Nov	19760209
A novel external esophageal perfusion model for reflux-associated respiratory symptoms.	2010	20516732
Prolonged hypoxemia and acidemia in anesthetized pigs: a model for research on extracorporeal organ support in an intensive care setting.	2010 Aug	20872349
Improved gas exchange and survival after KL-4 surfactant in newborn pigs with severe acute lung injury.	2010 Aug	20597076
Inflammatory mediators of esophagitis alter p27 Kip1 expression in esophageal epithelial cells.	2010 Nov	20818264
Role of the Rhesus glycoprotein, Rh B glycoprotein, in renal ammonia excretion.	2010 Nov	20719974
Expression of neutral endopeptidase activity during clinical and experimental acute lung injury.	2010 Nov 29	21114838
Loss of muscarinic and purinergic receptors in urinary bladder of rats with hydrochloric acid-induced cystitis.	2010 Oct	20719367
HCl-induced inflammatory mediators in esophageal mucosa increase migration and production of H2O2 by peripheral blood leukocytes.	2010 Sep	20616304
The effect of tidal volume on systemic inflammation in Acid-induced lung injury.	2011	21311175
Inhibitory effect of rosiglitazone on the acid-induced intracellular generation of hydrogen peroxide in cultured feline esophageal epithelial cells.	2011 Feb	21212935
Involvement of NADPH-dependent and cAMP-PKA sensitive H+ channels in the chorda tympani nerve responses to strong acids.	2011 May	21339339
JAK2-targeted anti-inflammatory effect of a resveratrol derivative 2,4-dihydroxy-N-(4-hydroxyphenyl)benzamide.	2013 Dec 15	24144632
Chemicals inducing acute irritant contact dermatitis mobilize intracellular calcium in human keratinocytes.	2013 Feb	22906572
The effect of thalidomide on ethanol-induced gastric mucosal damage in mice: involvement of inflammatory cytokines and nitric oxide.	2015 Jan 5	25478868

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:43:39 GMT 2023` Edited by `admin` on `Fri Dec 15 15:43:39 GMT 2023`
Record UNII	QTT17582CB
Record Status	`Validated (UNII)`
Record Version

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Classification Tree Code System Code

EPA PESTICIDE CODE

45901