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Details

Stereochemistry ACHIRAL
Molecular Formula C8H10IN3
Molecular Weight 279.0915
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of IOBENGUANE I-131

SMILES

c1cc(cc(c1)I)CNC(=N)N

InChI

InChIKey=PDWUPXJEEYOOTR-JRGAVVOBSA-N
InChI=1S/C8H10IN3/c9-7-3-1-2-6(4-7)5-12-8(10)11/h1-4H,5H2,(H4,10,11,12)/i9+4

HIDE SMILES / InChI

Molecular Formula C8H10IN3
Molecular Weight 279.0915
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Iobenguane I-131 is a radioactive therapeutic agent. The drug contains radioactive isotope I-131, which decays by electron emission with a half-life of about 8 days. By the chemical structure, iobenguane is similar to the neurotransmitter norepinephrine and is subject to the same uptake and regulation pathways. After intravenous administration, iobenguane I-131 accumulates within pheochromocytoma and paraganglioma cells, and radiation from the radioactive decay causes cell death and tumor necrosis. Iobenguane I-131 was approved by the FDA for the treatment of adult and pediatric patients with iobenguane scan positive, unresectable, locally advanced or metastatic pheochromocytoma or paraganglioma who require systemic anticancer therapy. Iobenguane I-131 is investigated in clinical trials as a treatment of neuroblastoma, ganglioneuroblastoma and other tumors of neuroendocrinal origin.

Approval Year

Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Diagnostic
IOBENGUANE SULFATE I 131

Approved Use

Iobenguane sulfate I 131 Injection is indicated as an adjunctive diagnostic agent in the localization of primary or metastatic pheochromocytomas and neuroblastomas.

Launch Date

7.6446722E11
PubMed

PubMed

TitleDatePubMed
Iodine-131 metaiodobenzylguanidine therapy for neuroblastoma: reports so far and future perspective.
2015
Treatment for Patients With Malignant Pheochromocytomas and Paragangliomas: A Perspective From the Hallmarks of Cancer.
2018
Substance Class Chemical
Created
by admin
on Sat Jun 26 06:01:30 UTC 2021
Edited
by admin
on Sat Jun 26 06:01:30 UTC 2021
Record UNII
Q461L7AK4R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
IOBENGUANE I-131
Common Name English
IOBENGUANE I 131
USAN   USP  
USAN  
Official Name English
GUANIDINE, ((3-(IODO-(SUP 131)I)PHENYL)METHYL)-
Common Name English
131 I-MIBG
Common Name English
IOBENGUANE I-131 [ORANGE BOOK]
Common Name English
I-131 METAIODOBENZYLGUANIDINE
Common Name English
COLD CONTAMINANT-FREE IOBENGUANE I-131
Common Name English
IOBENGUANE I 131 [USP]
Common Name English
AZEDRA
Brand Name English
3-IODOBENZYLGUANIDINE, I-131
Common Name English
131I-MIBG
Common Name English
(131I)-MIBG
Common Name English
IOBENGUANE (131I) [INN]
Common Name English
3-IODOBENZYLGUANIDINE (131I)
JAN  
Common Name English
IOBENGUANE, I-131
Common Name English
ULTRATRACE IODINE I 131 METAIODOBENZYLGUANIDINE
Brand Name English
IOBENGUANE (131I)
INN  
INN  
Official Name English
METAIODOBENZYLGUANIDINE I-131
Common Name English
(M-((SUP 131)I)IODOBENZYL)GUANIDINE
Common Name English
IOBENGUANE (131 I)
WHO-DD  
Common Name English
MIBG I-131
Common Name English
3-IODOBENZYLGUANIDINE (131I) [JAN]
Common Name English
IOBENGUANE (131 I) [WHO-DD]
Common Name English
IODINE (131I) IOBENGUANE
Common Name English
IOBENGUANE I 131 [USAN]
Common Name English
Classification Tree Code System Code
EU-Orphan Drug EU/3/07/525
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
WHO-VATC QV10XA02
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
WHO-ATC V09IX02
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
NDF-RT N0000177914
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
WHO-VATC QV09IX02
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
WHO-ATC V10XA02
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
NDF-RT N0000000205
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
FDA ORPHAN DRUG 241907
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
NCI_THESAURUS C2124
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
FDA ORPHAN DRUG 216205
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
Code System Code Type Description
NCI_THESAURUS
C82344
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
ALTERNATIVE
PUBCHEM
71184
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
ChEMBL
CHEMBL818
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
EVMPD
SUB08203MIG
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
INN
6088
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
NCI_THESAURUS
C970
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
DRUG CENTRAL
4577
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
RXCUI
2053281
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
CAS
77679-27-7
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
EVMPD
SUB127284
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
ALTERNATIVE
LACTMED
Iobenguane I 131
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
EPA CompTox
77679-27-7
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
FDA UNII
Q461L7AK4R
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
DRUG BANK
DBSALT002472
Created by admin on Sat Jun 26 06:01:30 UTC 2021 , Edited by admin on Sat Jun 26 06:01:30 UTC 2021
PRIMARY
Related Record Type Details
SALT/SOLVATE -> PARENT
TARGET -> SUBSTRATE
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ACTIVE MOIETY