U.S. Department of Health & Human Services Divider Arrow National Institutes of Health Divider Arrow NCATS

Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 04:49:22 GMT 2025
Edited
by admin
on Wed Apr 02 04:49:22 GMT 2025
Protein Sub Type
Sequence Type COMPLETE
Record UNII
PW7453NX3R
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR
Common Name English
ABCC7
Preferred Name English
POMULMERAN EXPRESSED ABCC7 PROTEIN
Common Name English
CHANNEL CONDUCTANCE-CONTROLLING ATPASE
Common Name English
CAMP-DEPENDENT CHLORIDE CHANNEL
Common Name English
ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 7
Common Name English
CFTR
Common Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 63891
Created by admin on Wed Apr 02 04:49:22 GMT 2025 , Edited by admin on Wed Apr 02 04:49:22 GMT 2025
Code System Code Type Description
UNIPROT
P13569
Created by admin on Wed Apr 02 04:49:22 GMT 2025 , Edited by admin on Wed Apr 02 04:49:22 GMT 2025
PRIMARY
FDA UNII
PW7453NX3R
Created by admin on Wed Apr 02 04:49:22 GMT 2025 , Edited by admin on Wed Apr 02 04:49:22 GMT 2025
PRIMARY
Glycosylation Type HUMAN
Glycosylation Link Type Site
N 1_894
N 1_900
Related Record Type Details
Structure of VPO-227
INHIBITOR -> TARGET
IC50
Structure of Vanzacaftor
MODULATOR->TARGET
POMULMERAN
GENE REPLACEMENT->TARGET
Structure of Riselcaftor
MODULATOR->TARGET
PRECLINICAL
Structure of IVACAFTOR
ACTIVATOR -> TARGET
POMULMERAN
VECTOR->EXPRESSED PROTEIN
Structure of DEUTIVACAFTOR
ACTIVATOR -> TARGET
Structure of NESOLICAFTOR
MODULATOR->TARGET
Structure of NAVOCAFTOR
ACTIVATOR -> TARGET
Structure of Icenticaftor
ACTIVATOR -> TARGET
Structure of DIROCAFTOR
ACTIVATOR -> TARGET
PTI-808 is a small molecule “potentiator” that is intended to rescue mutant cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity. The Sponsor intends to develop PTI-808 as part of a triple combination therapy with PTI-801 (CFTR “corrector”) and PTI-428 (CFTR “amplifier”) in cystic fibrosis patients
HUMAN PLACENTAL TISSUE
TISSUE EXPRESSION->TRANSPORTER
APICAL
Structure of GLPG-1837
ACTIVATOR -> TARGET
Structure of XO-176
ACTIVATOR -> TARGET
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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