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Details

Stereochemistry ACHIRAL
Molecular Formula C22H28N2O3Si2
Molecular Weight 424.6403
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of DIROCAFTOR

SMILES

C[Si](C)(C)C1=CC(=C(O)C=C1NC(=O)C2=CNC3=C(C=CC=C3)C2=O)[Si](C)(C)C

InChI

InChIKey=TYQIFWXBQYAKCR-UHFFFAOYSA-N
InChI=1S/C22H28N2O3Si2/c1-28(2,3)19-12-20(29(4,5)6)18(25)11-17(19)24-22(27)15-13-23-16-10-8-7-9-14(16)21(15)26/h7-13,25H,1-6H3,(H,23,26)(H,24,27)

HIDE SMILES / InChI

Molecular Formula C22H28N2O3Si2
Molecular Weight 424.6403
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

Substance Class Chemical
Created
by admin
on Sat Dec 16 13:40:34 UTC 2023
Edited
by admin
on Sat Dec 16 13:40:34 UTC 2023
Record UNII
2G3T6M1AS9
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
DIROCAFTOR
USAN   INN  
Official Name English
DIROCAFTOR [USAN]
Common Name English
dirocaftor [INN]
Common Name English
N-[5-Hydroxy-2,4-bis(trimethylsilyl)phenyl]-4-oxo-1,4-dihydroquinoline-3-carboxamide
Systematic Name English
3-QUINOLINECARBOXAMIDE, 1,4-DIHYDRO-N-(5-HYDROXY-2,4-BIS(TRIMETHYLSILYL)PHENYL)-4-OXO-
Systematic Name English
PTI-808
Code English
Code System Code Type Description
PUBCHEM
141671949
Created by admin on Sat Dec 16 13:40:34 UTC 2023 , Edited by admin on Sat Dec 16 13:40:34 UTC 2023
PRIMARY
NCI_THESAURUS
C175060
Created by admin on Sat Dec 16 13:40:34 UTC 2023 , Edited by admin on Sat Dec 16 13:40:34 UTC 2023
PRIMARY
SMS_ID
300000025632
Created by admin on Sat Dec 16 13:40:34 UTC 2023 , Edited by admin on Sat Dec 16 13:40:34 UTC 2023
PRIMARY
INN
11355
Created by admin on Sat Dec 16 13:40:34 UTC 2023 , Edited by admin on Sat Dec 16 13:40:34 UTC 2023
PRIMARY
FDA UNII
2G3T6M1AS9
Created by admin on Sat Dec 16 13:40:34 UTC 2023 , Edited by admin on Sat Dec 16 13:40:34 UTC 2023
PRIMARY
CAS
2137932-23-9
Created by admin on Sat Dec 16 13:40:34 UTC 2023 , Edited by admin on Sat Dec 16 13:40:34 UTC 2023
PRIMARY
USAN
GH-70
Created by admin on Sat Dec 16 13:40:34 UTC 2023 , Edited by admin on Sat Dec 16 13:40:34 UTC 2023
PRIMARY
Related Record Type Details
TARGET -> ACTIVATOR
PTI-808 is a small molecule “potentiator” that is intended to rescue mutant cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel activity. The Sponsor intends to develop PTI-808 as part of a triple combination therapy with PTI-801 (CFTR “corrector”) and PTI-428 (CFTR “amplifier”) in cystic fibrosis patients
Related Record Type Details
ACTIVE MOIETY
Name Property Type Amount Referenced Substance Defining Parameters References
NOAEL TOXICITY ORGAN SYSTEM OR TYPE OF EFFECT
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SPECIES
TOXICITY
ROUTE OF ADMINISTRATION
TOXICITY
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