POMULMERAN

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NCATS

Investigational

Investigational

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 07:58:24 GMT 2025` Edited by `admin` on `Wed Apr 02 07:58:24 GMT 2025`
Record UNII	AW2ZDE8CAS
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

POMULMERAN

Official Name

English

pomulmeran [INN]

Preferred Name

English

MESSENGER RNA (MRNA), 5' CAPPED, ENCODING CODON-OPTIMISED HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR (CFTR; CHANNEL CONDUCTANCE-CONTROLLING ATPASE, CAMP-DEPENDENT CHLORIDE CHANNEL, ATP-BINDING CASSETTE SUB-FAMILY C MEMBER 7, ABCC7), FLANKE

Common Name

English

RNA (RECOMBINANT 5'-(M7G-(5'->5')-PPP-GM)-CAPPED HUMAN CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR PROTEIN-SPECIFYING POLY(A)-TAILED MESSENGER HCFTRPA1), INNER SALT

Common Name

English

Code System Code Type Description

NCI_THESAURUS

C175847

Created by admin on Wed Apr 02 07:58:24 GMT 2025 , Edited by admin on Wed Apr 02 07:58:24 GMT 2025

PRIMARY

INN

11392

Created by admin on Wed Apr 02 07:58:24 GMT 2025 , Edited by admin on Wed Apr 02 07:58:24 GMT 2025

PRIMARY

CAS

2304576-72-3

Created by admin on Wed Apr 02 07:58:24 GMT 2025 , Edited by admin on Wed Apr 02 07:58:24 GMT 2025

PRIMARY

FDA UNII

AW2ZDE8CAS

Created by admin on Wed Apr 02 07:58:24 GMT 2025 , Edited by admin on Wed Apr 02 07:58:24 GMT 2025

PRIMARY

SMS_ID

100000178355

Created by admin on Wed Apr 02 07:58:24 GMT 2025 , Edited by admin on Wed Apr 02 07:58:24 GMT 2025

PRIMARY

Sugar	Site Range	Site Count
D-Ribose (RNA)	1_1-1_4687	4687 / 4687

Linkage	Site Range	Site Count
Phosphate	1_2-1_4687	4686 / 4686

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CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

EXPRESSED PROTEIN->VECTOR

Amount:


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CYSTIC FIBROSIS TRANSMEMBRANE CONDUCTANCE REGULATOR

TARGET->GENE REPLACEMENT

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Related Record Type Details


					AW2ZDE8CAS

ACTIVE MOIETY

Comments:

Immunomodulator

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOTIDE SUBSTITUTION	[1_1]	5'-TERMINUS			5'-GUANOSINE-M-RNA-CAP-1-3'-PHOSPHATE	T0HQY09X7B
NUCLEOTIDE SUBSTITUTION	[1_4687]	3'-TERMINUS			UNSPECIFIED SUBSTANCE	4bdb5480 (not in database)