Gimistotug

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 12:30:25 GMT 2025` Edited by `admin` on `Wed Apr 02 12:30:25 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	PT47RQF9HF
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BGB-A445

Preferred Name

English

Gimistotug

Official Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens TNFRSF4 (tumor necrosis factor receptor (TNFR) superfamily member 4, OX40, CD134)], humanized monoclonal antibody

Common Name

English

BGBA445

Code

English

gimistotug [INN]

Common Name

English

H-gamma1 heavy chain humanized (1-450) [VH (Homo sapiens IGHV1-46*01 (84.7%) -(IGHD) -IGHJ4*01 (92.3%) L123>T (115), CDR-IMGT [8.8.13] (26-33.51-58.97-109)) (1-120) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (217) (121-

Common Name

English

Code System Code Type Description

SMS_ID

300000054749

Created by admin on Wed Apr 02 12:30:25 GMT 2025 , Edited by admin on Wed Apr 02 12:30:25 GMT 2025

PRIMARY

CAS

2768487-95-0

Created by admin on Wed Apr 02 12:30:25 GMT 2025 , Edited by admin on Wed Apr 02 12:30:25 GMT 2025

PRIMARY

NCI_THESAURUS

C175453

Created by admin on Wed Apr 02 12:30:25 GMT 2025 , Edited by admin on Wed Apr 02 12:30:25 GMT 2025

PRIMARY

INN

12710

Created by admin on Wed Apr 02 12:30:25 GMT 2025 , Edited by admin on Wed Apr 02 12:30:25 GMT 2025

PRIMARY

FDA UNII

PT47RQF9HF

Created by admin on Wed Apr 02 12:30:25 GMT 2025 , Edited by admin on Wed Apr 02 12:30:25 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_147	2_203
2_223	4_214
2_264	2_324
1_147	1_203
2_370	2_428
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_223	3_214
1_229	2_229
1_232	2_232
1_264	1_324
1_370	1_428

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_300
N	2_300

Related Record Type Details


					115VXA358P

TUMOR NECROSIS FACTOR RECEPTOR SUPERFAMILY MEMBER 4

TARGET -> AGONIST

Interaction Type:

IN-VITRO

Amount:

Related Record Type Details


					PT47RQF9HF

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_450] [2_450]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL