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Details

Stereochemistry ACHIRAL
Molecular Formula C12H13NO4S
Molecular Weight 267.301
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ALADORIAN

SMILES

COC1=CC=C2SCCN(CC2=C1)C(=O)C(O)=O

InChI

InChIKey=FPWBHFYYVSNIFZ-UHFFFAOYSA-N
InChI=1S/C12H13NO4S/c1-17-9-2-3-10-8(6-9)7-13(4-5-18-10)11(14)12(15)16/h2-3,6H,4-5,7H2,1H3,(H,15,16)

HIDE SMILES / InChI

Molecular Formula C12H13NO4S
Molecular Weight 267.301
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

ARMGO and Servier are developing an anti-arrhythmia drug aladorian (ARM036) for the treatment of heart failure, arrhythmia and ventricular tachycardia. Aladorian was the first in-house discovered, novel, small molecule NCE (Rycal®) from ARMGO’s library that was advanced into clinical studies. ARM036 completed multiple Phase IIa clinical studies in chronic heart failure patients, demonstrating positive activity and safety in patients, and validating ARMGO’s approach for drug discovery and candidate selection on the RyR target.

Approval Year

PubMed

PubMed

TitleDatePubMed
Analytical approaches for the detection of emerging therapeutics and non-approved drugs in human doping controls.
2014 Dec
Patents

Sample Use Guides

Rats: 1.11 mg/kg/day ARM036 given via osmotic pump
Route of Administration: Oral
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:01:22 GMT 2023
Edited
by admin
on Fri Dec 15 16:01:22 GMT 2023
Record UNII
PJ5KSA836G
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ALADORIAN
INN   USAN   WHO-DD  
INN   USAN  
Official Name English
S-441211
Code English
aladorian [INN]
Common Name English
ARM036
Code English
Aladorian [WHO-DD]
Common Name English
S36
Code English
S44121-1
Code English
(7-Methoxy-2,3-dihydro-1,4-benzothiazepin-4(5H)-yl)oxoacetic acid
Systematic Name English
ARM-036
Code English
ALADORIAN [USAN]
Common Name English
S-44121-1
Code English
S-36
Code English
Code System Code Type Description
FDA UNII
PJ5KSA836G
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
USAN
YY-112
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
PUBCHEM
11161474
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
CAS
865433-00-7
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
INN
9614
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
NCI_THESAURUS
C174843
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
ChEMBL
CHEMBL2104951
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
SMS_ID
300000034051
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
EPA CompTox
DTXSID40235657
Created by admin on Fri Dec 15 16:01:22 GMT 2023 , Edited by admin on Fri Dec 15 16:01:22 GMT 2023
PRIMARY
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