Ruxoprubart

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 04:11:07 GMT 2025` Edited by `admin` on `Wed Apr 02 04:11:07 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	P9NB0SOG5X
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

NM-8074

Preferred Name

English

Ruxoprubart

Official Name

English

RUXOPRUBART [USAN]

Common Name

English

NM8074

Code

English

Immunoglobulin G1 [301-alanine], anti-(human complement factor Bb) (human-Mus musculus monoclonal NM8074 ?1-chain), disulfide with human-Mus musculus monoclonal NM8074 ?-chain, dimer

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

835921

Created by admin on Wed Apr 02 04:11:07 GMT 2025 , Edited by admin on Wed Apr 02 04:11:07 GMT 2025

Code System Code Type Description

INN

13213

Created by admin on Wed Apr 02 04:11:07 GMT 2025 , Edited by admin on Wed Apr 02 04:11:07 GMT 2025

PRIMARY

FDA UNII

P9NB0SOG5X

Created by admin on Wed Apr 02 04:11:07 GMT 2025 , Edited by admin on Wed Apr 02 04:11:07 GMT 2025

PRIMARY

NCI_THESAURUS

C199294

Created by admin on Wed Apr 02 04:11:07 GMT 2025 , Edited by admin on Wed Apr 02 04:11:07 GMT 2025

PRIMARY

CAS

2842046-67-5

Created by admin on Wed Apr 02 04:11:07 GMT 2025 , Edited by admin on Wed Apr 02 04:11:07 GMT 2025

PRIMARY

SMS_ID

300000054723

Created by admin on Wed Apr 02 04:11:07 GMT 2025 , Edited by admin on Wed Apr 02 04:11:07 GMT 2025

PRIMARY

USAN

LM-108

Created by admin on Wed Apr 02 04:11:07 GMT 2025 , Edited by admin on Wed Apr 02 04:11:07 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_148	2_204
2_224	4_214
2_265	2_325
1_148	1_204
2_371	2_429
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_224	3_214
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429

Related Record Type Details


					QV1AX6DC3R

COMPLEMENT FACTOR BB

TARGET -> INHIBITOR

Amount:


					3635PCK4HN

COMPLEMENT FACTOR B

TARGET -> INHIBITOR

Amount:

Related Record Type Details


					P9NB0SOG5X

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_451] [2_451]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL