TACLAMINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H23N
Molecular Weight	289.414
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@@]12CCCCN1C[C@@]3([H])C4=C(CCC5=CC=CC2=C35)C=CC=C4

InChI

InChIKey=BFHGFZIDLRXFJE-PMACEKPBSA-N

InChI=1S/C21H23N/c1-2-8-17-15(6-1)11-12-16-7-5-9-18-20-10-3-4-13-22(20)14-19(17)21(16)18/h1-2,5-9,19-20H,3-4,10-14H2/t19-,20-/m0/s1

HIDE SMILES / InChI

Molecular Formula	C21H23N
Molecular Weight	289.414
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1156020 | https://www.ncbi.nlm.nih.gov/pubmed/6140017

Taclamine is an isoquinoline derivative patented by Ayerst, McKenna and Harrison Ltd. as central nervous system depressant and anti-inflammatory agent. In preclinical models, Taclamine antagonizes the turnover of noradrenaline and dopamine in the rat brain during immobilization stress without effects on brain serotonin turnover

Originator

Approval Year

PubMed

Title	Date	PubMed
Effects of taclamine (AY-22,214), a new psychoactive agent, on catecholamine and serotonin metabolism.	1975 Jan	1156020

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 18:27:54 GMT 2023` Edited by `admin` on `Fri Dec 15 18:27:54 GMT 2023`
Record UNII	P98BJE9F79
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TACLAMINE

Official Name

English

TACLAMINE, (4AS-TRANS)-ISOMER

Common Name

English

taclamine [INN]

Common Name

English

1H-BENZO(6,7)CYCLOHEPTA(1,2,3-DE)PYRIDO(2,1-A)ISOQUINOLINE, 2,3,4,4A,8,9,13B,14-OCTAHYDRO-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78272