TACLAMINE HYDROCHLORIDE

Details

Stereochemistry	RACEMIC
Molecular Formula	C21H23N.ClH
Molecular Weight	325.875
Optical Activity	( + / - )
Defined Stereocenters	2 / 2
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

Cl.[H][C@@]12CCCCN1C[C@@]3([H])C4=C(CCC5=CC=CC2=C35)C=CC=C4

InChI

InChIKey=LOSFVNFVCCXCEN-FKLPMGAJSA-N

InChI=1S/C21H23N.ClH/c1-2-8-17-15(6-1)11-12-16-7-5-9-18-20-10-3-4-13-22(20)14-19(17)21(16)18;/h1-2,5-9,19-20H,3-4,10-14H2;1H/t19-,20-;/m0./s1

HIDE SMILES / InChI

Molecular Formula	ClH
Molecular Weight	36.461
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C21H23N
Molecular Weight	289.414
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	2 / 2
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1156020 | https://www.ncbi.nlm.nih.gov/pubmed/6140017

Taclamine is an isoquinoline derivative patented by Ayerst, McKenna and Harrison Ltd. as central nervous system depressant and anti-inflammatory agent. In preclinical models, Taclamine antagonizes the turnover of noradrenaline and dopamine in the rat brain during immobilization stress without effects on brain serotonin turnover

Originator

Approval Year

PubMed

Title	Date	PubMed

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:02:45 GMT 2023` Edited by `admin` on `Fri Dec 15 15:02:45 GMT 2023`
Record UNII	0R94K6TJ5B
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TACLAMINE HYDROCHLORIDE

Official Name

English

AY-22214

Code

English

TACLAMINE HYDROCHLORIDE [USAN]

Common Name

English

AY-22,214

Code

English

1H-BENZO(6,7)CYCLOHEPTA(1,2,3-DE)PYRIDO(2,1-A)ISOQUINOLINE, 2,3,4,4A,8,9,13B,14-OCTAHYDRO-, HYDROCHLORIDE

Common Name

English

TACLAMINE HYDROCHLORIDE, (4AS-TRANS)-ISOMER (±)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C78272