Umesolerbart

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 17:28:25 GMT 2023` Edited by `admin` on `Sat Dec 16 17:28:25 GMT 2023`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	P6GDS36Y2P
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

Umesolerbart

Official Name

English

REGN5714

Code

English

Immunoglobulin G4 [227-proline], anti-(Betula alleghaniensis allergen Bet v 1) (human monoclonal REGN5714 γ4-chain), disulfide with human monoclonal REGN5714 κ-chain, dimer

Common Name

English

immunoglobulin G4-kappa, anti-[Bet v 1 (Betula alleghaniensis (yellow birch) pollen allergen 1], Homo sapiens monoclonal antibody

Common Name

English

umesolerbart [INN]

Common Name

English

REGN-5714

Code

English

gamma4 heavy chain Homo sapiens (1-446) [VH(Homo sapiens IGHV3-48*03 (92.9%) -(IGHD)-IGHJ5*01 (92.9%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119)-Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92 (CH1 (120-217), hinge 1-12 S10>P (227) (218-229), CH

Common Name

English

Code System Code Type Description

CAS

2456307-11-0

Created by admin on Sat Dec 16 17:28:25 GMT 2023 , Edited by admin on Sat Dec 16 17:28:25 GMT 2023

PRIMARY

INN

12258

Created by admin on Sat Dec 16 17:28:25 GMT 2023 , Edited by admin on Sat Dec 16 17:28:25 GMT 2023

PRIMARY

FDA UNII

P6GDS36Y2P

Created by admin on Sat Dec 16 17:28:25 GMT 2023 , Edited by admin on Sat Dec 16 17:28:25 GMT 2023

PRIMARY

NCI_THESAURUS

C190475

Created by admin on Sat Dec 16 17:28:25 GMT 2023 , Edited by admin on Sat Dec 16 17:28:25 GMT 2023

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_133	4_214
2_146	2_202
2_260	2_320
1_133	3_214
2_366	2_424
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_146	1_202
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					P6GDS36Y2P

Umesolerbart

ACTIVE MOIETY

Comments:

As determined using SPR technology, the REGN5713, REGN5714, and REGN5715 equilibrium dissociation constants (KD) for nBet v 1 were 187, 933, and 747pM, respectively (Module 2.6.2 Section 2.1.1). REGN5713, REGN5714, and REGN5715 also bound rCar b 1 with KD values of 2.16, 59.1, and 1.91nM, respectively

Amount:

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL