Umesolerbart

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 09:11:35 GMT 2025` Edited by `admin` on `Wed Apr 02 09:11:35 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	P6GDS36Y2P
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Umesolerbart

Official Name

English

REGN-5714

Preferred Name

English

REGN5714

Code

English

Immunoglobulin G4 [227-proline], anti-(Betula alleghaniensis allergen Bet v 1) (human monoclonal REGN5714 ?4-chain), disulfide with human monoclonal REGN5714 ?-chain, dimer

Common Name

English

immunoglobulin G4-kappa, anti-[Bet v 1 (Betula alleghaniensis (yellow birch) pollen allergen 1], Homo sapiens monoclonal antibody

Common Name

English

umesolerbart [INN]

Common Name

English

gamma4 heavy chain Homo sapiens (1-446) [VH(Homo sapiens IGHV3-48*03 (92.9%) -(IGHD)-IGHJ5*01 (92.9%), CDR-IMGT [8.8.12] (26-33.51-58.97-108)) (1-119)-Homo sapiens IGHG4*01, G4v5 h P10, nG4m(a) CH2 L92 (CH1 (120-217), hinge 1-12 S10>P (227) (218-229), CH

Common Name

English

Code System Code Type Description

CAS

2456307-11-0

Created by admin on Wed Apr 02 09:11:35 GMT 2025 , Edited by admin on Wed Apr 02 09:11:35 GMT 2025

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INN

12258

Created by admin on Wed Apr 02 09:11:35 GMT 2025 , Edited by admin on Wed Apr 02 09:11:35 GMT 2025

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SMS_ID

300000040673

Created by admin on Wed Apr 02 09:11:35 GMT 2025 , Edited by admin on Wed Apr 02 09:11:35 GMT 2025

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FDA UNII

P6GDS36Y2P

Created by admin on Wed Apr 02 09:11:35 GMT 2025 , Edited by admin on Wed Apr 02 09:11:35 GMT 2025

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NCI_THESAURUS

C190475

Created by admin on Wed Apr 02 09:11:35 GMT 2025 , Edited by admin on Wed Apr 02 09:11:35 GMT 2025

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From	To
1_22	1_96
2_22	2_96
2_133	4_214
2_146	2_202
2_260	2_320
1_133	3_214
2_366	2_424
3_23	3_88
3_134	3_194
4_23	4_88
4_134	4_194
1_146	1_202
1_225	2_225
1_228	2_228
1_260	1_320
1_366	1_424

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_296
N	2_296

Related Record Type Details


					P6GDS36Y2P

ACTIVE MOIETY

Comments:

As determined using SPR technology, the REGN5713, REGN5714, and REGN5715 equilibrium dissociation constants (KD) for nBet v 1 were 187, 933, and 747pM, respectively (Module 2.6.2 Section 2.1.1). REGN5713, REGN5714, and REGN5715 also bound rCar b 1 with KD values of 2.16, 59.1, and 1.91nM, respectively

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_446] [2_446]	C-TERMINUS		Amount:	LYSINE	K3Z4F929H6
AMINO_ACID_SUBSTITUTION	[3_1] [4_1]	N-TERMINUS		Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER AVERAGE	CHEMICAL