Details
| Stereochemistry | ABSOLUTE |
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.3661 |
| Optical Activity | UNSPECIFIED |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Charge | 0 |
SHOW SMILES / InChI
SMILES
[H][C@@]12CC[C@H](O)[C@@]1(C)C=CC3=C4CCC(=O)C=C4CC[C@@]23[H]
InChI
InChIKey=MEHHPFQKXOUFFV-OWSLCNJRSA-N
InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h8-10,15-17,20H,2-7H2,1H3/t15-,16+,17+,18+/m1/s1
| Molecular Formula | C18H22O2 |
| Molecular Weight | 270.3661 |
| Charge | 0 |
| Count |
|
| Stereochemistry | ABSOLUTE |
| Additional Stereochemistry | No |
| Defined Stereocenters | 4 / 4 |
| E/Z Centers | 0 |
| Optical Activity | UNSPECIFIED |
DescriptionCurator's Comment: description was created based on several sources, including:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de1d618f-7e27-4307-9330-0e1a2255ee95
http://www.wikidoc.org/index.php/Trenbolone
Curator's Comment: description was created based on several sources, including:
https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=de1d618f-7e27-4307-9330-0e1a2255ee95
http://www.wikidoc.org/index.php/Trenbolone
Trenbolone is an anabolic steroid. It is used on livestock to increase muscle growth and appetite. Trenbolone compounds have a binding affinity for the androgen receptor three times as high as that of testosterone. Once metabolized, the drugs have the effect of increasing nitrogen uptake by muscles, leading to an increase in the rate of protein synthesis. It also has the secondary effects of stimulating appetite, reducing the amount of fat being deposited in the body, and decreasing the rate of catabolism. Short-term side effects include insomnia, high blood pressure, increased aggression, night sweats, and libido.
Approval Year
Targets
| Primary Target | Pharmacology | Condition | Potency |
|---|---|---|---|
Target ID: CHEMBL1871 |
0.15 nM [Kd] | ||
Target ID: CHEMBL208 |
|||
Target ID: CHEMBL2034 |
53.0 nM [Kd] |
Conditions
| Condition | Modality | Targets | Highest Phase | Product |
|---|---|---|---|---|
| Primary | Finaplix®-H Approved UseIncreases rate of weight gain and improves feed efficiency. Launch Date1987 |
PubMed
| Title | Date | PubMed |
|---|---|---|
| [Simple and rapid analysis of trenbolone and zeranol residues in cattle muscle and liver by stack-cartridge solid-phase extraction and HPLC using on-line clean-up with EC and UV detection]. | 2001 Aug |
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| Biochemistry and physiology of anabolic hormones used for improvement of meat production. | 2001 Jan |
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| Assessment of oestrogenic potency of chemicals used as growth promoter by in-vitro methods. | 2001 May |
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| Sensor chip preparation and assay construction for immunobiosensor determination of beta-agonists and hormones. | 2001 Oct |
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| Determination of trenbolone and its metabolite in bovine fluids by liquid chromatography-tandem mass spectrometry. | 2003 Jan 25 |
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| Single-laboratory validation of a modified liquid chromatographic method with UV detection for determination of trenbolone residues in bovine liver and muscle. | 2003 Sep-Oct |
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| Androgenic and estrogenic activity in water bodies receiving cattle feedlot effluent in Eastern Nebraska, USA. | 2004 Mar |
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| Screening of anabolic steroids in horse urine by liquid chromatography-tandem mass spectrometry. | 2005 Apr 29 |
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| Fluctuating asymmetry and growth as biomarkers for exposure to androgen disrupting chemicals in Japanese quail. | 2005 Aug |
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| Decrease in anogenital distance among male infants with prenatal phthalate exposure. | 2005 Aug |
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| Detection, quantification and confirmation of anabolic steroids in equine plasma by liquid chromatography and tandem mass spectrometry. | 2005 Dec 27 |
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| Evaluation of the rodent Hershberger bioassay using three reference (anti)androgens. | 2005 Jun |
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| Structural and functional diversity of microbial communities from a lake sediment contaminated with trenbolone, an endocrine-disrupting chemical. | 2005 Sep |
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| Collision-induced dissociation pathways of anabolic steroids by electrospray ionization tandem mass spectrometry. | 2006 Apr |
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| Doping control analysis in human urine by liquid chromatography-electrospray ionization ion trap mass spectrometry for the Olympic Games Athens 2004: determination of corticosteroids and quantification of ephedrines, salbutamol and morphine. | 2006 Jul 28 |
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| [Rhabdomyolysis in a bodybuilder using steroids]. | 2006 May 13 |
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| Gene expression patterns in rainbow trout, Oncorhynchus mykiss, exposed to a suite of model toxicants. | 2006 May 25 |
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| Rapid screening of doping agents in human urine by vacuum MALDI-linear ion trap mass spectrometry. | 2007 Aug 1 |
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| Modulation of steroidogenic gene expression and hormone production of H295R cells by pharmaceuticals and other environmentally active compounds. | 2007 Dec 1 |
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| Immunotoxicity of trenbolone acetate in Japanese quail. | 2007 Jan |
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| Analysis of synthetic 19-norsteroids trenbolone, tetrahydrogestrinone and gestrinone by gas chromatography-mass spectrometry. | 2007 May 25 |
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| A league of their own: demographics, motivations and patterns of use of 1,955 male adult non-medical anabolic steroid users in the United States. | 2007 Oct 11 |
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| Evaluation of the rodent Hershberger bioassay: testing of coded chemicals and supplementary molecular-biological and biochemical investigations. | 2007 Sep 24 |
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| Screening of in vitro synthesised metabolites of 4,9,11-trien-3-one steroids by liquid chromatography mass spectrometry. | 2008 |
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| Induction of micronuclei in V79 cells by the anabolic doping steroids tetrahydrogestrinone and trenbolone. | 2008 Apr |
|
| [Determination of three anabolic steroids by liquid chromatography-mass spectrometry]. | 2008 Jul |
|
| Confirmatory analysis of Trenbolone using accurate mass measurement with LC/TOF-MS. | 2008 Jun 16 |
|
| Comparison of estrogen-responsive plasma protein biomarkers and reproductive endpoints in sheepshead minnows exposed to 17beta-trenbolone. | 2008 Jun 23 |
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| Trace analysis of androgens and progestogens in environmental waters by ultra-performance liquid chromatography-electrospray tandem mass spectrometry. | 2008 Jun 27 |
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| Degradation of synthetic androgens 17alpha- and 17beta-trenbolone and trendione in agricultural soils. | 2008 May 15 |
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| Distribution of trenbolone residues in liver and various muscle groups of heifers that received multiple implants at the recommended site of application. | 2008 May-Jun |
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| [Determination of eleven steroid hormones in animal muscle tissues and eggs using ultra-performance liquid chromatography-tandem mass spectrometry]. | 2008 Nov |
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| The development of multiple drug use among anabolic-androgenic steroid users: six subjective case reports. | 2008 Nov 28 |
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| Determination of trenbolone residual in bovine liver by liquid chromatography-mass spectrometry. | 2009 Apr |
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| The watershed as a conceptual framework for the study of environmental and human health. | 2009 Feb 18 |
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| Synthesis and SAR study of novel pseudo-steroids as potent and selective progesterone receptor antagonists. | 2009 Jul 15 |
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| Doping control analysis of trenbolone and related compounds using liquid chromatography-tandem mass spectrometry. | 2009 Mar |
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| Confirmatory method for the determination of nandrolone and trenbolone in urine samples using immunoaffinity cleanup and liquid chromatography-tandem mass spectrometry. | 2009 Nov 13 |
|
| Analysis of anabolic steroids in hair: time courses in guinea pigs. | 2009 Sep |
|
| Is the gonadotropin releasing hormone system vulnerable to endocrine disruption in birds? | 2009 Sep 1 |
|
| In vitro study of Organization for Economic Co-operation and Development (OECD) endocrine disruptor screening and testing methods- establishment of a recombinant rat androgen receptor (rrAR) binding assay. | 2010 Apr |
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| Generic sample preparation combined with high-resolution liquid chromatography-time-of-flight mass spectrometry for unification of urine screening in doping-control laboratories. | 2010 Apr |
|
| Synthesis and characterization of new aromatic esters based on 4,16-pregnadiene-6,20-dione skeleton. | 2010 Dec 8 |
|
| Trenbolone causes irreversible masculinization of zebrafish at environmentally relevant concentrations. | 2010 Jul 15 |
|
| Soil temperature and moisture effects on the persistence of synthetic androgen 17alpha-trenbolone, 17beta-trenbolone and trendione. | 2010 May |
|
| Assessing the fate and transformation by-product potential of trenbolone during chlorination. | 2010 Nov |
Patents
Sample Use Guides
One implant containing 200 mg trenbolone acetate is administered to each animal. The implant is placed under the skin on the posterior aspect of the ear by means of a special implanter.
Route of Administration:
Other
| Substance Class |
Chemical
Created
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| Record UNII |
P53R4420TR
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| Record Status |
Validated (UNII)
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WIKIPEDIA |
Designer-drugs-Trenbolone
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CFR |
21 CFR 556.739
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NCI_THESAURUS |
C2360
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DEA NO. |
4000
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SUB11232MIG
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1484278
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P53R4420TR
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P53R4420TR
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TRENBOLONE
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100000077481
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m11015
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DB11551
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10161-33-8
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CHEMBL1698011
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C95072
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| Related Record | Type | Details | ||
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METABOLITE INACTIVE -> PARENT | |||
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PRODRUG -> METABOLITE ACTIVE |
| Related Record | Type | Details | ||
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PARENT -> IMPURITY |
CHROMATOGRAPHIC PURITY (HPLC/UV)
USP
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| Related Record | Type | Details | ||
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ACTIVE MOIETY |
