TOMARALIMAB

Investigational

Approval Year

Substance Class	Protein Created by `admin` on `Mon Mar 31 21:43:54 GMT 2025` Edited by `admin` on `Mon Mar 31 21:43:54 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG4
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	P45C2W27DU
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

TOMARALIMAB

Official Name

English

OPN-305

Preferred Name

English

HUMANIZED IGG4 MONOCLONAL ANTIBODY AGAINST TOLL-LIKE RECEPTOR 2 FOR PREVENTION OF ISCHEMIA/REPERFUSION TISSUE INJURY

Common Name

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-( HOMO SAPIENS TOLL-LIKE RECEPTOR 2 (CD282 ANTIGEN))HUMANIZED MOUSE MONOCLONAL ANTIBODY.GAMMA.4 HEAVY CHAIN (1-445) (MUS MUSCULUS VH (IGHV1-85*01 (82%) (IGHD)-IGHJ4*01 (86%)) (8.8.11) (1-118)-HOMO SAPIENS IGHG4*01 (HINGE(S10

Systematic Name

English

Tomaralimab [WHO-DD]

Common Name

English

ANTI-TLR2 MONOCLONAL ANTIBODY OPN-305

Common Name

English

TOMARALIMAB [USAN]

Common Name

English

IMMUNOGLOBULIN G4, ANTI-(HUMAN TOLL-LIKE RECEPTOR TLR-2) (HUMAN-MUS MUSCULUS MONOCLONAL OPN-305 HEAVY CHAIN), DISULFIDE WITH HUMAN-MUS MUSCULUS MONOCLONAL OPN-305 LIGHT CHAIN, DIMER

Systematic Name

English

IMMUNOGLOBULIN G4-KAPPA, ANTI-(HOMO SAPIENS TLR2 (TOLL LIKE RECEPTOR 2, TOLL-LIKE RECEPTOR 2, TIL4, CD282)), MONOCLONAL ANTIBODYGAMMA4 HEAVY CHAIN (1-445) (VH (MUS MUSCULUS IGHV1-85*01 (80.6%)-(IGHD)-IGHJ4*01 (85.7%)/HOMO SAPIENS IGHV1-8*03 (73.5%)-(IGHD

Systematic Name

English

tomaralimab [INN]

Common Name

English

Classification Tree Code System Code

FDA ORPHAN DRUG

355311

Created by admin on Mon Mar 31 21:43:54 GMT 2025 , Edited by admin on Mon Mar 31 21:43:54 GMT 2025

NCI_THESAURUS

C129822

Created by admin on Mon Mar 31 21:43:55 GMT 2025 , Edited by admin on Mon Mar 31 21:43:55 GMT 2025

FDA ORPHAN DRUG

455014

Created by admin on Mon Mar 31 21:43:54 GMT 2025 , Edited by admin on Mon Mar 31 21:43:54 GMT 2025

NCI_THESAURUS

C20401

Created by admin on Mon Mar 31 21:43:55 GMT 2025 , Edited by admin on Mon Mar 31 21:43:55 GMT 2025

Code System Code Type Description

NCI_THESAURUS

C120554

Created by admin on Mon Mar 31 21:43:54 GMT 2025 , Edited by admin on Mon Mar 31 21:43:54 GMT 2025

PRIMARY

INN

11044

Created by admin on Mon Mar 31 21:43:54 GMT 2025 , Edited by admin on Mon Mar 31 21:43:54 GMT 2025

PRIMARY

DRUG BANK

DB15415

Created by admin on Mon Mar 31 21:43:55 GMT 2025 , Edited by admin on Mon Mar 31 21:43:55 GMT 2025

PRIMARY

CAS

1449294-76-1

Created by admin on Mon Mar 31 21:43:55 GMT 2025 , Edited by admin on Mon Mar 31 21:43:55 GMT 2025

PRIMARY

SMS_ID

100000175121

Created by admin on Mon Mar 31 21:43:55 GMT 2025 , Edited by admin on Mon Mar 31 21:43:55 GMT 2025

PRIMARY

CAS

1569475-31-5

Created by admin on Mon Mar 31 21:43:54 GMT 2025 , Edited by admin on Mon Mar 31 21:43:54 GMT 2025

ALTERNATIVE

USAN

FG-15

Created by admin on Mon Mar 31 21:43:55 GMT 2025 , Edited by admin on Mon Mar 31 21:43:55 GMT 2025

PRIMARY

FDA UNII

P45C2W27DU

Created by admin on Mon Mar 31 21:43:55 GMT 2025 , Edited by admin on Mon Mar 31 21:43:55 GMT 2025

PRIMARY

From	To
1_22	1_96
1_145	1_201
1_259	1_319
1_365	1_423
2_22	2_96
2_145	2_201
2_259	2_319
2_365	2_423
3_23	3_92
4_23	4_92
3_138	3_198
4_138	4_198
1_132	3_218
2_132	4_218
1_224	2_224
1_227	2_227

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_295
N	2_295

Related Record Type Details


					MEG7LMR9E8

TOLL-LIKE RECEPTOR 2

TARGET -> INHIBITOR

Comments:

OPN-305 binds to the ligand-binding site on the TLR2 receptor and blocks the activation of TLR2-mediated innate immunity signaling.

Interaction Type:

INHIBITOR

Related Record Type Details


					P45C2W27DU

TOMARALIMAB

ACTIVE MOIETY

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL