Bocunebart

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 11:39:00 GMT 2025` Edited by `admin` on `Wed Apr 02 11:39:00 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED RABBIT
Sequence Type	COMPLETE
Record UNII	P457A8A6EH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

Bocunebart

Official Name

English

LU AG-09222

Preferred Name

English

IGHV3-66*01 (81.4%) -(IGHD) -IGHJ1*01 (100%), CDR-IMGT [8.7.6] (26-33.51-57.96-101)) (1-112) -Homo sapiens IGHG1*03v, G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14, 8-G1v29 CH2 A84.4 (CH1 R120>K (209) (113-210), hinge 1-15 (211-225), CH2 N84.4>A (292) (226-33

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens ADCYAP1 (adenylate cyclase-activating polypeptide 1, pituitary adenylate cyclase-activating polypeptide, PACAP)], humanized monoclonal antibody

Common Name

English

Immunoglobulin G1 [292-alanine], anti-(human pituitary adenylate cyclase-activating peptide) (human-Oryctolagus cuniculus monoclonal Lu AG09222 ?1-chain), disulfide with human-Oryctolagus cuniculus monoclonal Lu AG09222 ?-chain, dimer

Common Name

English

LU AG09222

Code

English

bocunebart [INN]

Common Name

English

Code System Code Type Description

FDA UNII

P457A8A6EH

Created by admin on Wed Apr 02 11:39:00 GMT 2025 , Edited by admin on Wed Apr 02 11:39:00 GMT 2025

PRIMARY

CAS

2984605-64-1

Created by admin on Wed Apr 02 11:39:00 GMT 2025 , Edited by admin on Wed Apr 02 11:39:00 GMT 2025

PRIMARY

INN

13356

Created by admin on Wed Apr 02 11:39:00 GMT 2025 , Edited by admin on Wed Apr 02 11:39:00 GMT 2025

PRIMARY

From	To
1_23	1_96
2_23	2_96
2_140	2_196
2_216	4_217
2_257	2_317
1_140	1_196
2_363	2_421
3_24	3_90
3_137	3_197
4_24	4_90
4_137	4_197
1_216	3_217
1_222	2_222
1_225	2_225
1_257	1_317
1_363	1_421

Related Record Type Details


					LK78T72MLT

PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE 38

TARGET->LIGAND

Comments:

Pre-Clinical

Interaction Type:

IN-VIVO

Amount:


					J974J07M1G

PITUITARY ADENYLATE CYCLASE-ACTIVATING POLYPEPTIDE 27

TARGET->LIGAND

Comments:

Pre-Clinical

Interaction Type:

IN-VIVO

Amount:

Related Record Type Details


					P457A8A6EH

Bocunebart

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION	[1_1] [2_1]	N-TERMINUS	Q		PIDOLIC ACID	SZB83O1W42
AMINO ACID REMOVAL	[1_443] [2_443]	C-TERMINUS	K	Amount:	LYSINE	K3Z4F929H6

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL