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Approval Year

Unknown
149124
Substance Class Protein
Created
by admin
on Wed Apr 02 08:38:57 GMT 2025
Edited
by admin
on Wed Apr 02 08:38:57 GMT 2025
Protein Type MONOCLONAL ANTIBODY
Protein Sub Type IGG1
Sequence Type COMPLETE
Record UNII
ON09TCS5H3
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
PRA-023
Preferred Name English
Tulisokibart
USAN   INN  
Official Name English
PRA023
Code English
immunoglobulin G1-kappa, anti-[Homo sapiensTNFSF15(tumor necrosis factor (TNF) superfamily member 15, TL1A, vascular endothelial cell growth inhibitor 192-A, VEGI192A), membrane and soluble], humanized monoclonal antibody
Common Name English
tulisokibart [INN]
Common Name English
Immunoglobulin G1 [234-alanine,235-alanine,329-alanine], anti-(human tumor necrosis factor superfamily protein TNFSF15) (human monoclonal PRA023 ?1-chain), disulfide with human monoclonal PRA023 ?-chain, dimer
Common Name English
TULISOKIBART [USAN]
Common Name English
immunoglobulin G1-kappa, anti-[Homo sapiensTNFSF15 (tumor necrosis factor (TNF) superfamily member 15, TL1A, vascular endothelial cell growth inhibitor 192-A, VEGI192A), membrane and soluble], humanized monoclonal antibody; gamma1 heavy chain humanized (
Common Name English
Code System Code Type Description
USAN
LM-188
Created by admin on Wed Apr 02 08:38:57 GMT 2025 , Edited by admin on Wed Apr 02 08:38:57 GMT 2025
PRIMARY
SMS_ID
300000031533
Created by admin on Wed Apr 02 08:38:57 GMT 2025 , Edited by admin on Wed Apr 02 08:38:57 GMT 2025
PRIMARY
NCI_THESAURUS
C190474
Created by admin on Wed Apr 02 08:38:57 GMT 2025 , Edited by admin on Wed Apr 02 08:38:57 GMT 2025
PRIMARY
FDA UNII
ON09TCS5H3
Created by admin on Wed Apr 02 08:38:57 GMT 2025 , Edited by admin on Wed Apr 02 08:38:57 GMT 2025
PRIMARY
INN
12368
Created by admin on Wed Apr 02 08:38:57 GMT 2025 , Edited by admin on Wed Apr 02 08:38:57 GMT 2025
PRIMARY
CAS
2648504-55-4
Created by admin on Wed Apr 02 08:38:57 GMT 2025 , Edited by admin on Wed Apr 02 08:38:57 GMT 2025
PRIMARY
From To
2_219 4_213
1_219 3_213
2_143 2_199
2_22 2_96
4_133 4_193
4_23 4_87
3_133 3_193
3_23 3_87
2_366 2_424
2_260 2_320
1_366 1_424
1_260 1_320
1_228 2_228
1_225 2_225
1_143 1_199
1_22 1_96
Glycosylation Type MAMMALIAN
Glycosylation Link Type Site
N 1_296
N 2_296
Related Record Type Details
Tulisokibart
ACTIVE MOIETY

Structural Modifications

Modification Type Location Site Location Type Residue Modified Extent Fragment Name Fragment Approval
AMINO ACID REMOVAL [1_446] [2_446] C-TERMINUS LYSINE K3Z4F929H6
AMINO_ACID_SUBSTITUTION [1_1] [2_1] N-TERMINUS PIDOLIC ACID SZB83O1W42
Name Property Type Amount Referenced Substance Defining Parameters References
MOL_WEIGHT:NUMBER(CALCULATED) CHEMICAL
Molecular Formula CHEMICAL
NIH
NCATS
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