Details
Stereochemistry | ACHIRAL |
Molecular Formula | C22H24N6O2 |
Molecular Weight | 404.465 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
COC1=CC(C)=C(C=C1)N2CCC3=C2N=C(C)C=C3N4C=CC(=N4)N5CCNC5=O
InChI
InChIKey=JFHJGXQFESYQGY-UHFFFAOYSA-N
InChI=1S/C22H24N6O2/c1-14-12-16(30-3)4-5-18(14)26-9-6-17-19(13-15(2)24-21(17)26)28-10-7-20(25-28)27-11-8-23-22(27)29/h4-5,7,10,12-13H,6,8-9,11H2,1-3H3,(H,23,29)
Molecular Formula | C22H24N6O2 |
Molecular Weight | 404.465 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: P34998 Gene ID: 104909134|||1394 Gene Symbol: CRHR1 Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/18989952 |
66.0 nM [IC50] |
PubMed
Title | Date | PubMed |
---|---|---|
Corticotropin-releasing factor receptor 1 antagonist alters regional activation and effective connectivity in an emotional-arousal circuit during expectation of abdominal pain. | 2011 Aug 31 |
|
Impaired emotional learning and involvement of the corticotropin-releasing factor signaling system in patients with irritable bowel syndrome. | 2013 Dec |
|
Behavioral, biological, and chemical perspectives on targeting CRF(1) receptor antagonists to treat alcoholism. | 2013 Mar 1 |
Patents
Sample Use Guides
In Vivo Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/23954313
a single-center, randomized, double-blind, 3-period crossover study of 11 women with irritable bowel syndrome and 15 healthy women (controls) given a single oral dose (20 mg or 200 mg) of emicerfont (GW876008) or placebo
Route of Administration:
Oral
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 16:12:37 GMT 2023
by
admin
on
Fri Dec 15 16:12:37 GMT 2023
|
Record UNII |
OJ8EG4264P
|
Record Status |
Validated (UNII)
|
Record Version |
|
-
Download
Name | Type | Language | ||
---|---|---|---|---|
|
Official Name | English | ||
|
Code | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Code | English | ||
|
Common Name | English | ||
|
Systematic Name | English | ||
|
Code | English | ||
|
Common Name | English |
Code System | Code | Type | Description | ||
---|---|---|---|---|---|
|
C174801
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
786701-13-1
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
CHEMBL514270
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
300000034211
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
OJ8EG4264P
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
9196
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
DTXSID20229231
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
11223423
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
Emicerfont
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
DB12910
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY | |||
|
UU-140
Created by
admin on Fri Dec 15 16:12:37 GMT 2023 , Edited by admin on Fri Dec 15 16:12:37 GMT 2023
|
PRIMARY |
Related Record | Type | Details | ||
---|---|---|---|---|
|
TARGET -> INHIBITOR |
|
Related Record | Type | Details | ||
---|---|---|---|---|
|
ACTIVE MOIETY |
|