Details
Stereochemistry | ACHIRAL |
Molecular Formula | C21H22ClN3O2 |
Molecular Weight | 383.871 |
Optical Activity | NONE |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
CCC1=NN(C)C(C(=O)NCC2=CC=C(OC3=CC=C(C)C=C3)C=C2)=C1Cl
InChI
InChIKey=WPALTCMYPARVNV-UHFFFAOYSA-N
InChI=1S/C21H22ClN3O2/c1-4-18-19(22)20(25(3)24-18)21(26)23-13-15-7-11-17(12-8-15)27-16-9-5-14(2)6-10-16/h5-12H,4,13H2,1-3H3,(H,23,26)
Molecular Formula | C21H22ClN3O2 |
Molecular Weight | 383.871 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/27524698 | https://www.ncbi.nlm.nih.gov/pubmed/22743356Curator's Comment: Description was created based on several sources, including https://www.fsc.go.jp/english/evaluationreports/pesticide/evaluationreport_tolfenpyrad.pdf
Sources: https://www.ncbi.nlm.nih.gov/pubmed/27524698 | https://www.ncbi.nlm.nih.gov/pubmed/22743356
Curator's Comment: Description was created based on several sources, including https://www.fsc.go.jp/english/evaluationreports/pesticide/evaluationreport_tolfenpyrad.pdf
Tolfenpyrad is a pyrazole insecticide, and was discovered by Mitsubishi Chemical Corporation in 1991. The compound acts mainly through the inhibition of the mitochondrial electron transport system. Tolfenpyrad has shown activity against parasitic larval stages (xL3 and L4) of H. contortus in vitro; IC50 values were comparable with those of two commercially available anthelmintics, monepantel and moxidectin. As a pesticide, tolfenpyrad has relatively broad activity against egg, larval, nymphal and adult stages of various arthropods (including Hemiptera, Coleoptera, Diptera, Lepidoptera, Thysanoptera and Acarina), and has been applied to various infested crops. This chemical was developed in Japan and was first approved in 2002; it has been registered for commercial use in several countries other than Japan, including the Dominican Republic, Thailand, the United Arab Emirates, Indonesia and the USA.
Originator
Approval Year
Targets
Primary Target | Pharmacology | Condition | Potency |
---|---|---|---|
Target ID: CHEMBL613144 Sources: https://www.ncbi.nlm.nih.gov/pubmed/27524698 |
0.02 µM [IC50] |
Conditions
Condition | Modality | Targets | Highest Phase | Product |
---|---|---|---|---|
Curative | Unknown Approved UseUnknown |
Sample Use Guides
Beagle dogs (groups of 4 males and 4 females) were given tolfenpyrad, technical grade at 0, 1,
5, or 10 mg/kg bw/day for 1 year by gavage. Dogs in the 10 mg/kg bw/day group were given 20
mg/kg bw/day for the first 5 weeks.
Route of Administration:
Oral
In Vitro Use Guide
Sources: https://www.ncbi.nlm.nih.gov/pubmed/22743356
The cytotoxicity data show that the viability of SH-SY5Y cells at 24 h
was significantly below 80% for concentrations of tebufenpyrad ≥ 3 uM, genotoxicity was observed from 0.01 uM
Substance Class |
Chemical
Created
by
admin
on
Edited
Fri Dec 15 19:01:52 GMT 2023
by
admin
on
Fri Dec 15 19:01:52 GMT 2023
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Record UNII |
OHA74571QT
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Record Status |
Validated (UNII)
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Record Version |
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Classification Tree | Code System | Code | ||
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EPA PESTICIDE CODE |
90111
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admin on Fri Dec 15 19:01:52 GMT 2023 , Edited by admin on Fri Dec 15 19:01:52 GMT 2023
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tolfenpyrad
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38628
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10110536
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DTXSID6057952
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129558-76-5
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OHA74571QT
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