MEDIFOXAMINE FUMARATE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H19NO2.C4H4O4
Molecular Weight	373.3997
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	1
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

OC(=O)\C=C\C(O)=O.CN(C)CC(OC1=CC=CC=C1)OC2=CC=CC=C2

InChI

InChIKey=CSQUJXBMSDQIKM-WLHGVMLRSA-N

InChI=1S/C16H19NO2.C4H4O4/c1-17(2)13-16(18-14-9-5-3-6-10-14)19-15-11-7-4-8-12-15;5-3(6)1-2-4(7)8/h3-12,16H,13H2,1-2H3;1-2H,(H,5,6)(H,7,8)/b;2-1+

HIDE SMILES / InChI

Molecular Formula	C4H4O4
Molecular Weight	116.0722
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	1
Optical Activity	NONE

Molecular Formula	C16H19NO2
Molecular Weight	257.3276
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: | https://www.ncbi.nlm.nih.gov/pubmed/12506267 | https://www.ncbi.nlm.nih.gov/pubmed/7114665

Medifoxamine, an antidepressive drug, preferentially inhibits dopamine reuptake. It was marketed in France, but because of the hepatotoxicity, then was withdrawn.

Approval Year

PubMed

Title	Date	PubMed
[Hepatic tolerance of atypical antipsychotic drugs].	2002 Nov-Dec	12506267

Sample Use Guides

In Vivo Use Guide

After an overnight fast, ascending doses of 200, 500, 750 and 1000 mg of medifoxamine were taken orally

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:36:56 UTC 2023` Edited by `admin` on `Fri Dec 15 15:36:56 UTC 2023`
Record UNII	OAG6T7TVU2
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MEDIFOXAMINE FUMARATE

Common Name

English

MEDIFOXAMINE FUMARATE [MI]

Common Name

English

GERAXYL

Brand Name

English

ACETALDEHYDE, (DIMETHYLAMINO)-, DIPHENYL ACETAL, FUMARATE (1:1)

Common Name

English

LG 152

Code

English

N,N-DIMETHYL-N-(2,2-DIPHENOXYETHYL)AMINE FUMARATE

Systematic Name

English

Medifoxamine fumarate [WHO-DD]

Common Name

English

LG-152

Code

English

CLEDIAL

Brand Name

English

ETHANAMINE, N,N-DIMETHYL-2,2-DIPHENOXY-, (2E)-2-BUTENEDIOATE (1:1)

Systematic Name

English

ETHANAMINE, N,N-DIMETHYL-2,2-DIPHENOXY-, (E)-2-BUTENEDIOATE (1:1)

Systematic Name

English

Code System Code Type Description

MESH

C034065