MEDIFOXAMINE

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Details

Stereochemistry	ACHIRAL
Molecular Formula	C16H19NO2
Molecular Weight	257.3276
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of MEDIFOXAMINE

Structure Search

SMILES

CN(C)CC(OC1=CC=CC=C1)OC2=CC=CC=C2

InChI

InChIKey=QNMGHBMGNRQPNL-UHFFFAOYSA-N

InChI=1S/C16H19NO2/c1-17(2)13-16(18-14-9-5-3-6-10-14)19-15-11-7-4-8-12-15/h3-12,16H,13H2,1-2H3

HIDE SMILES / InChI

Molecular Formula	C16H19NO2
Molecular Weight	257.3276
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: | https://www.ncbi.nlm.nih.gov/pubmed/12506267 | https://www.ncbi.nlm.nih.gov/pubmed/7114665

Medifoxamine, an antidepressive drug, preferentially inhibits dopamine reuptake. It was marketed in France, but because of the hepatotoxicity, then was withdrawn.

Approval Year

PubMed

PubMed

Title	Date	PubMed
[Hepatic tolerance of atypical antipsychotic drugs].	2002-12-31	12506267

Sample Use Guides

In Vivo Use Guide

After an overnight fast, ascending doses of 200, 500, 750 and 1000 mg of medifoxamine were taken orally

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:36:18 GMT 2025` Edited by `admin` on `Mon Mar 31 18:36:18 GMT 2025`
Record UNII	KWU7C2A1NT
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

MEDIFOXAMINE

Official Name

English

MEDIFOXAMINE [MART.]

Preferred Name

English

medifoxamine [INN]

Common Name

English

Medifoxamine [WHO-DD]

Common Name

English

MEDIFOXAMINE [MI]

Common Name

English

(DIMETHYLAMINO)ACETALDEHYDE DIPHENYL ACETAL

Systematic Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66884

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

NCI_THESAURUS

C47794

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

WHO-VATC

QN06AX13

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

WHO-ATC

N06AX13

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

Code System Code Type Description

WIKIPEDIA

MEDIFOXAMINE

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

PUBCHEM

36109

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

SMS_ID

100000081990

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

RXCUI

29434

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

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RxNorm

MERCK INDEX

m7131

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

Merck Index

DRUG CENTRAL

1656

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

ChEMBL

CHEMBL85231

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

FDA UNII

KWU7C2A1NT

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

MESH

C034065

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

ECHA (EC/EINECS)

251-011-4

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

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CAS

32359-34-5

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

INN

3759

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

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EPA CompTox

DTXSID80186078

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

DRUG BANK

DB13219

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

NCI_THESAURUS

C83914

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

EVMPD

SUB08693MIG

Created by admin on Mon Mar 31 18:36:18 GMT 2025 , Edited by admin on Mon Mar 31 18:36:18 GMT 2025

PRIMARY

Related Record Type Details


					OAG6T7TVU2

MEDIFOXAMINE FUMARATE

SALT/SOLVATE -> PARENT

Related Record Type Details


					KWU7C2A1NT

ACTIVE MOIETY