MOROXYDINE

Details

Stereochemistry	ACHIRAL
Molecular Formula	C6H13N5O
Molecular Weight	171.2003
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

NC(=N)NC(=N)N1CCOCC1

InChI

InChIKey=KJHOZAZQWVKILO-UHFFFAOYSA-N

InChI=1S/C6H13N5O/c7-5(8)10-6(9)11-1-3-12-4-2-11/h1-4H2,(H5,7,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C6H13N5O
Molecular Weight	171.2003
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/9868507 | https://www.ncbi.nlm.nih.gov/pubmed/26428870

Moroxydine is an antiviral drug discovered in the 1950’s which was shown to be active against DNA and RNA viruses. Moroxydine analogues are potent anti-hepatitis C virus (HCV) agents.

Originator

Approval Year

Conditions

Condition	Modality	Targets	Highest Phase	Product
Viral infection 4 Sources: https://www.ncbi.nlm.nih.gov/pubmed/9868507	Primary		Approved 8429	VIRULEX FORTE Approved Use Unknown

PubMed

Title	Date	PubMed
Trisodium bis-{1-[iminio-(morpholino)meth-yl]guanidinium} bis-[hexa-hydrogen-hexa-molybdoaluminate(III)] chloride icosa-hydrate.	2008 Jul 26	21203050
Study of molecularly imprinted solid-phase extraction of diphenylguanidine and its structural analogs.	2009 Apr 20	19345756
Effect of N-[Imino(4-morpholyl)methyl]guanidine on the oxidative status in rats with toxic hepatitis.	2009 Oct	20396755
[The influense of guanidine derivatives on free radical oxidation intensity and aconitase activity at development of brain ischemia-reperfusion at rats].	2009 Sep-Oct	20017395

Patents

Sample Use Guides

In Vivo Use Guide

Daily dose ranges from 25 to 5600 mg.

Route of Administration: Other

In Vitro Use Guide

6.3 μg/mL Moroxydine suppresses apoptosis in grass carp reovirus (GCRV)-infected Ctenopharyngodon idella kidney (CIK) cells.

Substance Class	Chemical Created by `admin` on `Sat Dec 16 17:11:09 GMT 2023` Edited by `admin` on `Sat Dec 16 17:11:09 GMT 2023`
Record UNII	O611591WAH
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

MOROXYDINE

Official Name

English

SKF-8898A

Code

English

SKF-8898-A

Code

English

MOROXYDINE [MI]

Common Name

English

moroxydine [INN]

Common Name

English

SKF 8898-A

Code

English

N-CARBAMIMIDOYLMORPHOLINE-4-CARBOXIMIDAMIDE

Systematic Name

English

N-(AMINOIMINOMETHYL)-4-MORPHOLINECARBOXIMIDAMIDE

Systematic Name

English

ABOB

Common Name

English

Moroxydine [WHO-DD]

Common Name

English

4-MORPHOLINECARBOXIMIDOYLGUANIDINE

Systematic Name

English

MOROXYDINE [MART.]

Common Name

English

Classification Tree Code System Code

WHO-ATC

J05AX01