DERAMCICLANE

Details

Stereochemistry	ABSOLUTE
Molecular Formula	C20H31NO
Molecular Weight	301.4662
Optical Activity	UNSPECIFIED
Defined Stereocenters	3 / 3
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

[H][C@]12CC[C@](C)(C1(C)C)[C@@](C2)(OCCN(C)C)C3=CC=CC=C3

InChI

InChIKey=QOBGWWQAMAPULA-RLLQIKCJSA-N

InChI=1S/C20H31NO/c1-18(2)17-11-12-19(18,3)20(15-17,22-14-13-21(4)5)16-9-7-6-8-10-16/h6-10,17H,11-15H2,1-5H3/t17-,19-,20+/m1/s1

HIDE SMILES / InChI

Molecular Formula	C20H31NO
Molecular Weight	301.4662
Charge	0
Count

Stereochemistry	ABSOLUTE
Additional Stereochemistry	No
Defined Stereocenters	3 / 3
E/Z Centers	0
Optical Activity	UNSPECIFIED

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/19963003 | https://www.ncbi.nlm.nih.gov/pubmed/15949921 | https://www.ncbi.nlm.nih.gov/pubmed/9551765

Deramciclane is camphor derivative. It is an anxiolytic agent that binds with high affinity to 5-HT2A/2C receptor. Deramciclane showed significant evidence of efficacy for the treatment of generalized anxiety disorder in adult patients. A single dose of deramciclane was rapidly absorbed with peak plasma concentrations being reached after about 3 h. Deramciclane has a half-life of around 27 h. The most commonly reported adverse event was headache. In the in vitro studies deramciclane concentration-dependently inhibited NMDA evoked spreading depression.

Approval Year

PubMed

Title	Date	PubMed
Pharmacokinetics of deramciclane and N-desmethylderamciclane after single and repeated oral doses in healthy volunteers.	2004 Aug	15366325
Deramciclane in the treatment of generalized anxiety disorder: a placebo-controlled, double-blind, dose-finding study.	2005 Dec	15949921
Biotransformation of deramciclane in primary hepatocytes of rat, mouse, rabbit, dog, and human.	2005 Nov	16118331
Deramciclane improves object recognition in rats: potential role of NMDA receptors.	2010 Feb	19963003
Selective binding interactions of deramciclane to the genetic variants of human alpha(1)-acid glycoprotein.	2010 Mar	19720112

Patents

Sample Use Guides

In Vivo Use Guide

60 mg/day

Route of Administration: Oral

Substance Class	Chemical Created by `admin` on `Fri Dec 15 15:30:53 UTC 2023` Edited by `admin` on `Fri Dec 15 15:30:53 UTC 2023`
Record UNII	O5KFK61E74
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DERAMCICLANE

Official Name

English

deramciclane [INN]

Common Name

English

DERAMCICLANE [MI]

Common Name

English

Deramciclane [WHO-DD]

Common Name

English

Code System Code Type Description

INN

6838