XYLAMIDINE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H24N2O2
Molecular Weight	312.4061
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

COC1=CC(OC(C)CNC(=N)CC2=CC=CC(C)=C2)=CC=C1

InChI

InChIKey=JRYTUFKIORWTNI-UHFFFAOYSA-N

InChI=1S/C19H24N2O2/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21)

HIDE SMILES / InChI

Molecular Formula	C19H24N2O2
Molecular Weight	312.4061
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1762059 | https://www.ncbi.nlm.nih.gov/pubmed/2623027 | https://www.ncbi.nlm.nih.gov/pubmed/15527744

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

PubMed

Title	Date	PubMed
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.	2006-11-17	17029799
Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of alpha1-adrenoceptors and 5-HT2 receptors in conscious rats.	2006-03-27	16527267
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.	2004-12-03	15527744
Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit.	2004-03	15006475
Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.	2003-03	12603368
Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms.	1991-12	1762059
Effects of xylamidine on peripheral 5-hydroxytryptamine-induced anorexia.	1989-12	2623027

Substance Class	Chemical Created by `admin` on `Mon Mar 31 18:38:16 GMT 2025` Edited by `admin` on `Mon Mar 31 18:38:16 GMT 2025`
Record UNII	NY0PC84NZK
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

BENZENEETHANIMIDAMIDE, N-(2-(3-METHOXYPHENOXY)PROPYL)-3-METHYL-

Preferred Name

English

XYLAMIDINE

Common Name

English

N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE

Systematic Name

English

Code System Code Type Description

CAS

6443-50-1