XYLAMIDINE

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H24N2O2
Molecular Weight	312.4061
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

SMILES

COC1=CC(OC(C)CNC(=N)CC2=CC=CC(C)=C2)=CC=C1

InChI

InChIKey=JRYTUFKIORWTNI-UHFFFAOYSA-N

InChI=1S/C19H24N2O2/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21)

HIDE SMILES / InChI

Molecular Formula	C19H24N2O2
Molecular Weight	312.4061
Charge	0
Count	MOL RATIO 1 MOL RATIO (average)

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

PubMed

PubMed

Show entries

Title	Date	PubMed
Effects of xylamidine on peripheral 5-hydroxytryptamine-induced anorexia.	1989 Dec	2623027
Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms.	1991 Dec	1762059
Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.	2003 Mar	12603368
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.	2004 Dec 3	15527744
Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit.	2004 Mar	15006475