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Details

Stereochemistry RACEMIC
Molecular Formula C19H24N2O2
Molecular Weight 312.4061
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of XYLAMIDINE

SMILES

COC1=CC=CC(OC(C)CNC(=N)CC2=CC=CC(C)=C2)=C1

InChI

InChIKey=JRYTUFKIORWTNI-UHFFFAOYSA-N
InChI=1S/C19H24N2O2/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21)

HIDE SMILES / InChI

Molecular Formula C19H24N2O2
Molecular Weight 312.4061
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

PubMed

PubMed

TitleDatePubMed
Central and peripheral injections of the 5-HT2 agonist, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane, modify cardiovascular function through different mechanisms.
1991 Dec
Neurogenic dural protein extravasation induced by meta-chlorophenylpiperazine (mCPP) involves nitric oxide and 5-HT2B receptor activation.
2003 Mar
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.
2004 Dec 3
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.
2006 Nov 17
Substance Class Chemical
Created
by admin
on Fri Dec 15 16:56:25 UTC 2023
Edited
by admin
on Fri Dec 15 16:56:25 UTC 2023
Record UNII
NY0PC84NZK
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
XYLAMIDINE
Common Name English
N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE
Systematic Name English
BENZENEETHANIMIDAMIDE, N-(2-(3-METHOXYPHENOXY)PROPYL)-3-METHYL-
Systematic Name English
Code System Code Type Description
CAS
6443-50-1
Created by admin on Fri Dec 15 16:56:25 UTC 2023 , Edited by admin on Fri Dec 15 16:56:25 UTC 2023
PRIMARY
PUBCHEM
22951
Created by admin on Fri Dec 15 16:56:25 UTC 2023 , Edited by admin on Fri Dec 15 16:56:25 UTC 2023
PRIMARY
MESH
C005894
Created by admin on Fri Dec 15 16:56:25 UTC 2023 , Edited by admin on Fri Dec 15 16:56:25 UTC 2023
PRIMARY
FDA UNII
NY0PC84NZK
Created by admin on Fri Dec 15 16:56:25 UTC 2023 , Edited by admin on Fri Dec 15 16:56:25 UTC 2023
PRIMARY
EPA CompTox
DTXSID90863843
Created by admin on Fri Dec 15 16:56:25 UTC 2023 , Edited by admin on Fri Dec 15 16:56:25 UTC 2023
PRIMARY
WIKIPEDIA
XYLAMIDINE
Created by admin on Fri Dec 15 16:56:25 UTC 2023 , Edited by admin on Fri Dec 15 16:56:25 UTC 2023
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
SALT/SOLVATE -> PARENT
ENANTIOMER -> RACEMATE
SALT/SOLVATE -> PARENT
Related Record Type Details
ACTIVE MOIETY