XYLAMIDINE TOSYLATE ANHYDROUS

Possibly Marketed Outside US

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H24N2O2.C7H8O3S
Molecular Weight	484.608
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure of XYLAMIDINE TOSYLATE ANHYDROUS

Structure Search

SMILES

CC1=CC=C(C=C1)S(O)(=O)=O.COC2=CC=CC(OC(C)CNC(=N)CC3=CC=CC(C)=C3)=C2

InChI

InChIKey=FRJLUWKYXWADTA-UHFFFAOYSA-N

InChI=1S/C19H24N2O2.C7H8O3S/c1-14-6-4-7-16(10-14)11-19(20)21-13-15(2)23-18-9-5-8-17(12-18)22-3;1-6-2-4-7(5-3-6)11(8,9)10/h4-10,12,15H,11,13H2,1-3H3,(H2,20,21);2-5H,1H3,(H,8,9,10)

HIDE SMILES / InChI

Molecular Formula	C7H8O3S
Molecular Weight	172.202
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Molecular Formula	C19H24N2O2
Molecular Weight	312.4061
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/1762059 | https://www.ncbi.nlm.nih.gov/pubmed/2623027 | https://www.ncbi.nlm.nih.gov/pubmed/15527744

Xylamidine is a peripherally-restricted antagonist of 5HT2A and 5HT1A receptor. It is used to study the role of the serotonin receptors in the regulation of food intake, cardiovascular function, and regulation of body temperature.

Approval Year

PubMed

Title	Date	PubMed
Serotonin 2A receptors modulate tail-skin temperature in two rodent models of estrogen deficiency-related thermoregulatory dysfunction.	2004 Dec 3	15527744
Role of central 5-HT2 receptors in mediating head bobs and body shakes in the rabbit.	2004 Mar	15006475
Differential effects of nitroblue tetrazolium on the hemodynamic responses elicited by activation of alpha1-adrenoceptors and 5-HT2 receptors in conscious rats.	2006 Mar 27	16527267
5-HT activates vagal afferent cell bodies in vivo: role of 5-HT2 and 5-HT3 receptors.	2006 Nov 17	17029799

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:34:47 UTC 2023` Edited by `admin` on `Fri Dec 15 17:34:47 UTC 2023`
Record UNII	4ZF9UZ56C7
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

XYLAMIDINE TOSYLATE ANHYDROUS

Common Name

English

XYLAMIDE TOSILATE

Common Name

English

N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE MONO-P-TOLUENESULFONATE

Common Name

English

XYLAMIDINE TOSILATE

Official Name

English

XYLAMIDINE TOSYLATE

Official Name

English

XYLAMIDINE TOSYLATE [USAN]

Common Name

English

XYLAMIDINE TOSILATE ANHYDROUS

Common Name

English

xylamidine tosilate [INN]

Common Name

English

N-(2-(M-METHOXYPHENOXY)PROPYL)-2-M-TOLYLACETAMIDINE MONO-P-TOLUENESULPHONATE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66885