RILZABRUTINIB

U.S. Department of Health & Human Services Divider Arrow

National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Mixture
Record UNII	NWN58M4F5T
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

RILZABRUTINIB

Official Name

English

(E/Z)-(R)-2-(3-(4-AMINO-3-(2-FLUORO-4-PHENOXYPHENYL)-1H-PYRAZOLO(3,4-D)PYRIMIDIN-1-YL)PIPERIDINE-1-CARBONYL)-4-METHYL-4-(4-(OXETAN-3-YL)PIPERAZIN-1-YL)PENT-2-ENENITRILE

Systematic Name

English

PRN-1008

Common Name

English

1-PIPERIDINEPROPANENITRILE, 3-(4-AMINO-3-(2-FLUORO-4-PHENOXYPHENYL)-1H-PYRAZOLO(3,4-D)PYRIMIDIN-1-YL)-.ALPHA.-(2-METHYL-2-(4-(3-OXETANYL)-1-PIPERAZINYL)PROPYLIDENE)-.BETA.-OXO-, (.ALPHA.E/Z,3R)-

Systematic Name

English

PRN1008

Code

English

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Classification Tree

Code System

Code

Designated/Withdrawn

FDA ORPHAN DRUG

582517

Designated

FDA ORPHAN DRUG

605717

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Code System

Code

Type

Description

SMS_ID

100000177401

PRIMARY

INN

10966

PRIMARY

CAS

1575591-66-0

PRIMARY

USAN

HI-144

PRIMARY

NCI_THESAURUS

C174769

PRIMARY

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All of the following components must be present:


					5G1WE425BI

RILZABRUTINIB, (E)-


					0975516WHA

RILZABRUTINIB, (Z)-

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Related Record

Type

Details


					HG6WHF74KQ

TYROSINE-PROTEIN KINASE BTK C481F MUTANT

TARGET -> INHIBITOR

Comments:

PRN-1008 is a covalent, but reversible BTK inhibitor

Interaction Type:

BINDING

Qualification:

IC50

Amount:

RELATIONSHIP_AMOUNT 1.5 NANOMOLAR (average)

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Related Record

Type

Details


					NWN58M4F5T

ACTIVE MOIETY

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Definition References