TYROSINE-PROTEIN KINASE BTK C481F MUTANT

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NCATS

Approval Year

Substance Class	Protein Created by `admin` on `Sat Dec 16 18:05:52 GMT 2023` Edited by `admin` on `Sat Dec 16 18:05:52 GMT 2023`
Protein Type	REGULATOR PROTEIN
Protein Sub Type
Sequence Origin	HUMAN
Sequence Type	COMPLETE
Record UNII	HG6WHF74KQ
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

TYROSINE-PROTEIN KINASE BTK C481F MUTANT

Common Name

English

BRUTON TYROSINE KINASE C481F MUTANT

Common Name

English

B-CELL PROGENITOR KINASE C481F MUTANT

Common Name

English

BPK C481F MUTANT

Common Name

English

Code System Code Type Description

FDA UNII

HG6WHF74KQ

Created by admin on Sat Dec 16 18:05:53 GMT 2023 , Edited by admin on Sat Dec 16 18:05:53 GMT 2023

PRIMARY

Linkage Type	Residue Index
COORDINATION COMPOUND	1_142	1_153	1_154	1_164

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Interaction Type:

IRREVERSIBLE INHIBITOR

Amount:


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Interaction Type:

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Amount:


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INHIBITOR -> TARGET

Comments:

PRN-1008 is a covalent, but reversible BTK inhibitor

Interaction Type:

BINDING

Qualification:

IC50

Amount:


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Interaction Type:

IRREVERSIBLE INHIBITOR

Amount:


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INHIBITOR -> TARGET

Interaction Type:

IRREVERSIBLE INHIBITOR


					DRU6NG543J

INHIBITOR -> TARGET

Interaction Type:

IRREVERSIBLE INHIBITOR

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL