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Details

Stereochemistry ACHIRAL
Molecular Formula C12H16N8
Molecular Weight 272.309
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ST-1535

SMILES

CCCCC1=NC(N)=C2N=C(N(C)C2=N1)N3N=CC=N3

InChI

InChIKey=CYYQMAWUIRPCNW-UHFFFAOYSA-N
InChI=1S/C12H16N8/c1-3-4-5-8-16-10(13)9-11(17-8)19(2)12(18-9)20-14-6-7-15-20/h6-7H,3-5H2,1-2H3,(H2,13,16,17)

HIDE SMILES / InChI

Molecular Formula C12H16N8
Molecular Weight 272.309
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Approval Year

PubMed

PubMed

TitleDatePubMed
2-n-Butyl-9-methyl-8-[1,2,3]triazol-2-yl-9H-purin-6-ylamine and analogues as A2A adenosine receptor antagonists. Design, synthesis, and pharmacological characterization.
2005 Nov 3
ST 1535: a preferential A2A adenosine receptor antagonist.
2006 Oct
The novel adenosine A2a receptor antagonist ST1535 potentiates the effects of a threshold dose of L-DOPA in MPTP treated common marmosets.
2006 Sep 28
Adenosine A2A receptor antagonists improve deficits in initiation of movement and sensory motor integration in the unilateral 6-hydroxydopamine rat model of Parkinson's disease.
2007 Aug
The novel adenosine A2a antagonist ST1535 potentiates the effects of a threshold dose of l-dopa in unilaterally 6-OHDA-lesioned rats.
2007 Feb 16
Characterization of the antiparkinsonian effects of the new adenosine A2A receptor antagonist ST1535: acute and subchronic studies in rats.
2007 Jul 2
Interaction of A2A adenosine and D2 dopamine receptors modulates corticostriatal glutamatergic transmission.
2007 Nov
Behavioural and neurochemical characterization of the adenosine A2A receptor antagonist ST1535.
2008 Jan 28
A2A adenosine receptor antagonists protect the striatum against rotenone-induced neurotoxicity.
2009 May
Novel investigational adenosine A2A receptor antagonists for Parkinson's disease.
2009 Nov
Direct B-alkyl Suzuki-Miyaura cross-coupling of 2-halopurines. Practical synthesis of ST1535, a potent adenosine A2A receptor antagonist.
2010 Aug 6
Patents

Patents

Substance Class Chemical
Created
by admin
on Sat Dec 16 15:32:30 GMT 2023
Edited
by admin
on Sat Dec 16 15:32:30 GMT 2023
Record UNII
NTK8WWM73W
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ST-1535
Code English
CT-1500
Code English
2-butyl-9-methyl-8-(2H-1,2,3-triazol-2-yl)-9H-purin-6-amine
Systematic Name English
2-Butyl-9-methyl-8-(triazol-2-yl)purin-6-amine
Systematic Name English
Classification Tree Code System Code
FDA ORPHAN DRUG 811021
Created by admin on Sat Dec 16 15:32:30 GMT 2023 , Edited by admin on Sat Dec 16 15:32:30 GMT 2023
Code System Code Type Description
PUBCHEM
9860294
Created by admin on Sat Dec 16 15:32:30 GMT 2023 , Edited by admin on Sat Dec 16 15:32:30 GMT 2023
PRIMARY
CAS
496955-42-1
Created by admin on Sat Dec 16 15:32:30 GMT 2023 , Edited by admin on Sat Dec 16 15:32:30 GMT 2023
PRIMARY
FDA UNII
NTK8WWM73W
Created by admin on Sat Dec 16 15:32:30 GMT 2023 , Edited by admin on Sat Dec 16 15:32:30 GMT 2023
PRIMARY
EPA CompTox
DTXSID60432000
Created by admin on Sat Dec 16 15:32:30 GMT 2023 , Edited by admin on Sat Dec 16 15:32:30 GMT 2023
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY