OBIDOXIME

Details

Stereochemistry	ACHIRAL
Molecular Formula	C14H16N4O3
Molecular Weight	288.3018
Optical Activity	NONE
Defined Stereocenters	0 / 0
E/Z Centers	2
Charge	2

SHOW SMILES / InChI

Structure Search

SMILES

O\N=C\C1=CC=[N+](COC[N+]2=CC=C(C=C2)\C=N\O)C=C1

InChI

InChIKey=HIGRLDNHDGYWQJ-UHFFFAOYSA-P

InChI=1S/C14H14N4O3/c19-15-9-13-1-5-17(6-2-13)11-21-12-18-7-3-14(4-8-18)10-16-20/h1-10H,11-12H2/p+2

HIDE SMILES / InChI

Molecular Formula	C14H14N4O3
Molecular Weight	286.286
Charge	0
Count

Stereochemistry	ACHIRAL
Additional Stereochemistry	No
Defined Stereocenters	0 / 0
E/Z Centers	0
Optical Activity	NONE

Description
Sources: https://chemm.nlm.nih.gov/countermeasure_obidoxime.htm | https://www.ncbi.nlm.nih.gov/pubmed/26366467 | https://www.ncbi.nlm.nih.gov/pubmed/24250669 | http://esa.act.gov.au/wp-content/uploads/CMG-Pharmacology-OBIDOXIME-Jan10.pdf

Obidoxime is an antidote for organophosphorous nerve agent poisoning including chlorosarin, cyclosarin (GF), R-33 (VR), R-VX, sarin (GB), tabun (GA), VX, chlorosoman, soman (GD), and organophosphorous pesticides. It acts as an acetylcholinesterase (AChE) reactivator. In combination with atropine obidoxime can be used to treat super toxic organophosphate poisoning by relieving the symptoms of skeletal neuromuscular blocking that occurs during a cholinergic crisis.

Approval Year

Targets

Primary Target	Pharmacology	Condition	Potency
Acetylcholinesterase 207 Target ID: P22303\|\|\|Q53F46 Gene ID: 43.0 Gene Symbol: ACHE Target Organism: Homo sapiens (Human) Sources: https://www.ncbi.nlm.nih.gov/pubmed/20208964	Activator 1430

Patents

Substance Class	Chemical Created by `admin` on `Fri Dec 15 17:31:25 GMT 2023` Edited by `admin` on `Fri Dec 15 17:31:25 GMT 2023`
Record UNII	N6KNE1QA9O
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

OBIDOXIME

Common Name

English

PIPERIDINIUM, 1,1'-(OXYBIS(METHYLENE))BIS(4-((HYDROXYIMINO)METHYL)-

Common Name

English

1,1'-(OXYDIMETHYLENE)BIS(4-FORMYLPYRIDINIUM) DIOXIME

Systematic Name

English

Obidoxime [WHO-DD]

Common Name

English

PYRIDINIUM, 1,1'-(OXYBIS(METHYLENE))BIS(4-(HYDROXYIMINO)METHYL)-

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C66880