HOMOCHLORCYCLIZINE

Details

Stereochemistry	RACEMIC
Molecular Formula	C19H23ClN2
Molecular Weight	314.852
Optical Activity	( + / - )
Defined Stereocenters	0 / 1
E/Z Centers	0
Charge	0

SHOW SMILES / InChI

Structure Search

SMILES

CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=WEUCDJCFJHYFRL-UHFFFAOYSA-N

InChI=1S/C19H23ClN2/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17/h2-4,6-11,19H,5,12-15H2,1H3

HIDE SMILES / InChI

Molecular Formula	C19H23ClN2
Molecular Weight	314.852
Charge	0
Count

Stereochemistry	RACEMIC
Additional Stereochemistry	No
Defined Stereocenters	0 / 1
E/Z Centers	0
Optical Activity	( + / - )

Description
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14409112
Curator's Comment: description was created based on several sources, including http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf

Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965. It is used in the treatment of Itching sensation resulting from skin diseases (eczema or dermatitis, pruritus, drug eruption, toxic erythema and infant strophulus), urticaria and allergic rhinitis. Homochlorcyclizine hydrochloride possesses several pharmacological properties: 1) inhibits bradykinin-induced contractions of isolated guinea pig ileum; 2)partially blocks SRS-A (slow-reacting substance of anaphylaxis )- induced contractions in isolated guinea pig il eum. 3) Homochlorcyclizine hydrochloride completely inhibits histamine-induced contractions at a concentration of 0.1μg/mL, while it completely inhibits serotonin or acetylcholine- induced contractions at a concentration of 1μg/mL.

Originator

Approval Year

Conditions

Condition	Modality	Highest Phase	Product
Itching sensation resulting from skin diseases 4 Sources: http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf	Secondary	Approved 8429	Homoclomin Approved Use Unknown
Urticaria 39 Sources: http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf	Primary	Approved 8429	Homoclomin Approved Use Unknown
Allergic rhinitis 100 Sources: http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf	Primary	Approved 8429	Homoclomin Approved Use Unknown

PubMed

Title	Date	PubMed
Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol.	2003 Apr	12657913
Effect of (+) or (-) camphorsulfonic acid additives to the mobile phase on enantioseparations of some basic drugs on a Chiralcel OD column.	2005 Aug 12	16078699
Simultaneous determination of ten antihistamine drugs in human plasma using pipette tip solid-phase extraction and gas chromatography/mass spectrometry.	2006	16419026
A similarity search using molecular topological graphs.	2009	20037730
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.	2010 Dec	21818443
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.	2011 Jul 14	21599003

Sample Use Guides

In Vivo Use Guide

The usual adult dosage for oral use is 1 to 2 tablets (10 - 20 mg of homochlorcyclizine hydrochloride) three times daily.

Route of Administration: Oral

In Vitro Use Guide

Unknown

Substance Class	Chemical Created by `admin` on `Sat Dec 16 16:30:27 UTC 2023` Edited by `admin` on `Sat Dec 16 16:30:27 UTC 2023`
Record UNII	N5MVC31W2N
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

HOMOCHLORCYCLIZINE

Official Name

English

SA-97

Code

English

(±)-HOMOCHLORCYCLIZINE

Common Name

English

WICRON

Brand Name

English

1H-1,4-DIAZEPINE, 1-((4-CHLOROPHENYL)PHENYLMETHYL)HEXAHYDRO-4-METHYL-

Systematic Name

English

homochlorcyclizine [INN]

Common Name

English

SANKUMIN

Brand Name

English

HOMOCHLORCYCLIZINE [MI]

Common Name

English

NSC-25132

Code

English

1-(P-CHLORO-.ALPHA.-PHENYLBENZYL)HEXAHYDRO-4-METHYL-1H-1,4-DIAZEPINE

Common Name

English

Homochlorcyclizine [WHO-DD]

Common Name

English

CUROSAJIN

Brand Name

English

LYSILAN

Brand Name

English

1-(4-CHLORODIPHENYLMETHYL)-4-METHYL-2,3,4,5,6,7-HEXAHYDRO-1,4-DIAZEPINE

Common Name

English

Classification Tree Code System Code

NCI_THESAURUS

C29578