Details
Stereochemistry | RACEMIC |
Molecular Formula | C19H23ClN2.2ClH |
Molecular Weight | 387.774 |
Optical Activity | ( + / - ) |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Charge | 0 |
SHOW SMILES / InChI
SMILES
Cl.Cl.CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3
InChI
InChIKey=JLVFQWFTNVMTEG-UHFFFAOYSA-N
InChI=1S/C19H23ClN2.2ClH/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17;;/h2-4,6-11,19H,5,12-15H2,1H3;2*1H
Molecular Formula | ClH |
Molecular Weight | 36.461 |
Charge | 0 |
Count |
|
Stereochemistry | ACHIRAL |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 0 |
E/Z Centers | 0 |
Optical Activity | NONE |
Molecular Formula | C19H23ClN2 |
Molecular Weight | 314.852 |
Charge | 0 |
Count |
|
Stereochemistry | RACEMIC |
Additional Stereochemistry | No |
Defined Stereocenters | 0 / 1 |
E/Z Centers | 0 |
Optical Activity | ( + / - ) |
DescriptionSources: https://www.ncbi.nlm.nih.gov/pubmed/14409112Curator's Comment: description was created based on several sources, including
http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf
Sources: https://www.ncbi.nlm.nih.gov/pubmed/14409112
Curator's Comment: description was created based on several sources, including
http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf
Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965. It is used in the treatment of Itching sensation resulting from skin diseases (eczema or dermatitis, pruritus, drug eruption, toxic erythema and infant strophulus), urticaria and allergic rhinitis. Homochlorcyclizine hydrochloride possesses several pharmacological properties: 1) inhibits bradykinin-induced contractions of isolated guinea pig ileum; 2)partially blocks SRS-A (slow-reacting substance of anaphylaxis )- induced contractions in isolated guinea pig il eum. 3) Homochlorcyclizine hydrochloride completely inhibits histamine-induced contractions at a concentration of 0.1μg/mL, while it completely inhibits serotonin or acetylcholine- induced contractions at a concentration of 1μg/mL.
Originator
Approval Year
Substance Class |
Chemical
Created
by
admin
on
Edited
Sat Dec 16 06:01:43 UTC 2023
by
admin
on
Sat Dec 16 06:01:43 UTC 2023
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Record UNII |
M1YE3TK8NA
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Record Status |
Validated (UNII)
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m6041
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SUB02534MIG
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CHEMBL1515447
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1982-36-1
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100000086687
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169498
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24342-55-0
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M1YE3TK8NA
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ACTIVE MOIETY |