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Details

Stereochemistry RACEMIC
Molecular Formula C19H23ClN2.2ClH
Molecular Weight 387.774
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of HOMOCHLORCYCLIZINE DIHYDROCHLORIDE

SMILES

Cl.Cl.CN1CCCN(CC1)C(C2=CC=CC=C2)C3=CC=C(Cl)C=C3

InChI

InChIKey=JLVFQWFTNVMTEG-UHFFFAOYSA-N
InChI=1S/C19H23ClN2.2ClH/c1-21-12-5-13-22(15-14-21)19(16-6-3-2-4-7-16)17-8-10-18(20)11-9-17;;/h2-4,6-11,19H,5,12-15H2,1H3;2*1H

HIDE SMILES / InChI
Molecular Formula ClH
Molecular Weight 36.461
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE
Molecular Formula C19H23ClN2
Molecular Weight 314.852
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment: description was created based on several sources, including http://www.eisai.jp/medical/products/di/EPI/HC_T_EPI.pdf

Homochlorcyclizine (INN) is an antihistamine which has been marketed in Japan since 1965. It is used in the treatment of Itching sensation resulting from skin diseases (eczema or dermatitis, pruritus, drug eruption, toxic erythema and infant strophulus), urticaria and allergic rhinitis. Homochlorcyclizine hydrochloride possesses several pharmacological properties: 1) inhibits bradykinin-induced contractions of isolated guinea pig ileum; 2)partially blocks SRS-A (slow-reacting substance of anaphylaxis )- induced contractions in isolated guinea pig il eum. 3) Homochlorcyclizine hydrochloride completely inhibits histamine-induced contractions at a concentration of 0.1μg/mL, while it completely inhibits serotonin or acetylcholine- induced contractions at a concentration of 1μg/mL.

Originator

Eisai
53
Sources: US 2655498

Approval Year

Unknown
139594
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Secondary
Approved
8429
Homoclomin

Approved Use

Unknown
Primary
Approved
8429
Homoclomin

Approved Use

Unknown
Primary
Approved
8429
Homoclomin

Approved Use

Unknown
PubMed

PubMed

TitleDatePubMed
Role of mast cell chymase in allergen-induced biphasic skin reaction.
2002 Oct 1
Histamine H1-receptor antagonists, promethazine and homochlorcyclizine, increase the steady-state plasma concentrations of haloperidol and reduced haloperidol.
2003 Apr
Development of a list of potentially inappropriate drugs for the korean elderly using the delphi method.
2010 Dec
Profiling of a prescription drug library for potential renal drug-drug interactions mediated by the organic cation transporter 2.
2011 Jul 14

Sample Use Guides

In Vivo Use Guide
The usual adult dosage for oral use is 1 to 2 tablets (10 - 20 mg of homochlorcyclizine hydrochloride) three times daily.
Route of Administration: Oral
In Vitro Use Guide
Unknown
Substance Class Chemical
Created
by admin
on Sat Dec 16 06:01:43 GMT 2023
Edited
by admin
on Sat Dec 16 06:01:43 GMT 2023
Record UNII
M1YE3TK8NA
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
HOMOCHLORCYCLIZINE DIHYDROCHLORIDE
MI  
Common Name English
HOMOCHLORCYCLIZINE HYDROCHLORIDE
JAN   WHO-DD  
Common Name English
(±)-HOMOCHLORCYCLIZINE DIHYDROCHLORIDE
Common Name English
HOMOCHLORCYCLIZINE DIHYDROCHLORIDE [MI]
Common Name English
1H-1,4-DIAZEPINE, 1-(P-CHLORO-.ALPHA.-PHENYLBENZYL)HEXAHYDRO-4-METHYL-, DIHYDROCHLORIDE
Common Name English
1H-1,4-DIAZEPINE, 1-((4-CHLOROPHENYL)PHENYLMETHYL)HEXAHYDRO-4-METHYL-, HYDROCHLORIDE (1:2)
Systematic Name English
1-((4-CHLOROPHENYL)(PHENYL)METHYL)-4-METHYL-1,4-DIAZACYCLOHEPTANE DIHYDROCHLORIDE
Systematic Name English
HOMOCHLORCYCLIZINE HYDROCHLORIDE [JAN]
Common Name English
SA 97 DIHYDROCHLORIDE
Common Name English
HOMOCHLORCYCLIZINE DIHYDROCHLORIDE, (±)-
Common Name English
Homochlorcyclizine hydrochloride [WHO-DD]
Common Name English
NSC-169498
Code English
Code System Code Type Description
MERCK INDEX
m6041
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY Merck Index
EVMPD
SUB02534MIG
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY
ChEMBL
CHEMBL1515447
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY
CAS
1982-36-1
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY
SMS_ID
100000086687
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY
EPA CompTox
DTXSID70947190
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY
NSC
169498
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY
CAS
24342-55-0
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
NON-SPECIFIC STOICHIOMETRY
FDA UNII
M1YE3TK8NA
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY
PUBCHEM
16114
Created by admin on Sat Dec 16 06:01:43 GMT 2023 , Edited by admin on Sat Dec 16 06:01:43 GMT 2023
PRIMARY
Related Record Type Details
Structure of HOMOCHLORCYCLIZINE
PARENT -> SALT/SOLVATE
Related Record Type Details
Structure of HOMOCHLORCYCLIZINE
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