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Details

Stereochemistry RACEMIC
Molecular Formula C13H16N2
Molecular Weight 200.28
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MEDETOMIDINE

SMILES

Cc1cccc(c1C)C(C)c2cnc[nH]2

InChI

InChIKey=CUHVIMMYOGQXCV-UHFFFAOYSA-N
InChI=1S/C13H16N2/c1-9-5-4-6-12(10(9)2)11(3)13-7-14-8-15-13/h4-8,11H,1-3H3,(H,14,15)

HIDE SMILES / InChI

Molecular Formula C13H16N2
Molecular Weight 200.28
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment:: description was created based on several sources, including http://www.ncbi.nlm.nih.gov/pubmed/2571177

Domitor (medetomidine hydrochloride) is indicated for use in dogs: for restraint, sedation and analgesia associated with clinical examinations and procedures, minor surgery, pre-anaesthesia and as a premedicant before thiopentone-halothane general a naesthesiaand as a premedicant before general anaesthesia with propofol. In combination with butorphanol for sedation and analgesia, and as a premedicant prior to thiopentone anaesthesia. In cats: for restraint and sedation. Medetomidine is a potent and highly selective alpha2-adrenoreceptor agonist with both central and peripheral activity, and acting both presynaptically and postsynaptically. Its primary effects are sedative and analgesic resulting from its central depressant activity. It has no local anaesthetic properties. Like other compounds of its class there are secondary effects, including bradycardia. Blood pressure is increased but then returns to normal or just below. Body temperature is decreased in a dose dependent manner and intestinal motility is also reduced. The drug has been developed by Orion Pharma. It is currently approved for dogs in the United States, and distributed in the United States by Pfizer Animal Health and by Novartis Animal Health in Canada under the product name Domitor. The marketed product is a racemic mixture of two stereoisomers; dexmedetomidine is the isomer with more useful effects, and is now marketed as Dexdomitor.

CNS Activity

Curator's Comment:: Medetomidine is a potent and highly selective alpha2-adrenoreceptor agonist with both central and peripheral activity, and acting both presynaptically and postsynaptically. Its primary effects are sedative and analgesic resulting from its central depressant activity. It has no local anaesthetic properties

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
DOMITOR

Approved Use

Dogs: For restraint, sedation and analgesia associated with clinical examinations and procedures, minor surgery, pre-anaesthesia and as a premedicant before thiopentone-halothane general a naesthesiaand as a premedicant before general anaesthesia with propofol. Cats: For restraint and sedation.
PubMed

PubMed

TitleDatePubMed
Effects of anticholinergic treatment on the cardiac and respiratory systems in dogs sedated with medetomidine.
1991 Oct 5
Comparison of neurologic responses to the use of medetomidine as a sole agent or preanesthetic in laboratory beagles.
1992
Postoperative analgesic and cardiopulmonary effects in dogs of oxymorphone administered epidurally and intramuscularly, and medetomidine administered epidurally: a comparative clinical study.
1996 Jul-Aug
Effects of preemptive atropine administration on incidence of medetomidine-induced bradycardia in dogs.
2001 Jan 1
Reduced blood flow and oxygenation in SA-1 tumours after electrochemotherapy with cisplatin.
2002 Oct 21
Regulation of Cl- secretion by alpha2-adrenergic receptors in mouse colonic epithelium.
2003 Apr 15
[Domitor not to used in collies?].
2003 May 15
The effect of cartilage and bone density of mushroom-shaped, photooxidized, osteochondral transplants: an experimental study on graft performance in sheep using transplants originating from different species.
2005 Dec 15
Evaluation of two combinations of Domitor, Zoletil 100, and Euthatal to obtain long-term nonrecovery anesthesia in Sprague-Dawley rats.
2005 Jun
Perioperative normothermia depends on intraoperative warming procedure, extent of the surgical intervention and age of the experimental animal.
2005 Nov 4
Acute aortic rupture in a dog with spirocercosis following the administration of medetomidine.
2005 Sep
Radiosensitising effect of electrochemotherapy with bleomycin in LPB sarcoma cells and tumors in mice.
2005 Sep 16
Training-induced plasticity of auditory localization in adult mammals.
2006 Apr
Light stimulus frequency dependence of activity in the rat visual system as studied with high-resolution BOLD fMRI.
2006 May
Estrogen sensitivity of target genes and expression of nuclear receptor co-regulators in rat prostate after pre- and postnatal exposure to the ultraviolet filter 4-methylbenzylidene camphor.
2007 Dec
Degradable gelatin microspheres as an embolic agent: an experimental study in a rabbit renal model.
2007 Sep-Oct
A cardiovascular monitoring system used in conscious cynomolgus monkeys for regulatory safety pharmacology. Part 2: Pharmacological validation.
2007 Sep-Oct
Vascular disrupting action of electroporation and electrochemotherapy with bleomycin in murine sarcoma.
2008 Jan 29
IFN-lambda (IFN-lambda) is expressed in a tissue-dependent fashion and primarily acts on epithelial cells in vivo.
2008 Mar 14
EphrinB2 induces tyrosine phosphorylation of NR2B via Src-family kinases during inflammatory hyperalgesia.
2008 Sep 22
The effects of medetomidine hydrochloride on the electroretinogram of normal dogs.
2008 Sep-Oct
Serotonin transporter genotype modulates social reward and punishment in rhesus macaques.
2009
Late treatment with imatinib mesylate ameliorates radiation-induced lung fibrosis in a mouse model.
2009 Dec 21
Retrograde adenoviral vector targeting of nociresponsive pontospinal noradrenergic neurons in the rat in vivo.
2009 Jan 10
Seizures during medetomindine sedation and local anaesthesia in two dogs undergoing skin biopsy.
2009 May
Nitric oxide synthase enzymes in the airways of mice exposed to ovalbumin: NOS2 expression is NOS3 dependent.
2010
The non-lemniscal auditory cortex in ferrets: convergence of corticotectal inputs in the superior colliculus.
2010
Melody, an ENU mutation in Caspase 3, alters the catalytic cysteine residue and causes sensorineural hearing loss in mice.
2010 Dec
Manufacturing and in vivo inner ear visualization of MRI traceable liposome nanoparticles encapsulating gadolinium.
2010 Dec 18
Cancer treatment dosing regimens of zoledronic acid result in near-complete suppression of mandible intracortical bone remodeling in beagle dogs.
2010 Jan
Tissue restoration after implantation of polyglycolide, polydioxanone, polylevolactide, and metallic pins in cortical bone: an experimental study in rabbits.
2010 Jul
Sympathetic alpha(2)-adrenoceptors prevent cardiac hypertrophy and fibrosis in mice at baseline but not after chronic pressure overload.
2010 Jun 1
Lysophosphatidylcholine as an adjuvant for lentiviral vector mediated gene transfer to airway epithelium: effect of acyl chain length.
2010 Jun 23
Adaptation to stimulus statistics in the perception and neural representation of auditory space.
2010 Jun 24
Microscopic mammalian retinal pigment epithelium lesions induce widespread proliferation with differences in magnitude between center and periphery.
2010 Mar 31
Creating a population-averaged standard brain template for Japanese macaques (M. fuscata).
2010 Oct 1
Physiology and mRNA expression in rainbow trout (Oncorhynchus mykiss) after long-term exposure to the new antifoulant medetomidine.
2011 Sep
Patents

Patents

Sample Use Guides

In Vivo Use Guide
Curator's Comment:: Intended for injection by intramuscular, intravenous and subcutaneous routes in the dog, and by the intramuscular or subcutaneous route in the cat.
for animals: Dog: 10-30 µg/kg Slight sedation; 30-80 µg/kg Moderate to deep sedation and analgesia; 10-20 µg/kg Pre-anaesthesia Cat: 50-100 µg/kg Moderate sedation; 100-150 µg/kg Deep sedation;
Route of Administration: Other
In Vitro Use Guide
Rat pineal glands were incubated in oxygenated Krebs-Ringer solution in perifusion chambers, and perifused for 30 min with alpha(2)-adrenoceptor ligands. The melatonin concentrations were measured from the perifusate by radioimmunoassay. Medetomidine (>/=10(-5) M) increased melatonin release.
Substance Class Chemical
Created
by admin
on Sat Jun 26 14:43:12 UTC 2021
Edited
by admin
on Sat Jun 26 14:43:12 UTC 2021
Record UNII
MR15E85MQM
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MEDETOMIDINE
GREEN BOOK   INN   MI  
INN  
Official Name English
(+/-)-4-(.ALPHA.,2,3-TRIMETHYLBENZYL)IMIDAZOLE
Systematic Name English
MEDETOMIDINE [INN]
Common Name English
MEDETOMIDINE [GREEN BOOK]
Common Name English
1H-IMIDAZOLE, 4-(1-(2,3-DIMETHYLPHENYL)ETHYL)-, (+/-)-
Systematic Name English
MEDETOMIDINE [MI]
Common Name English
Classification Tree Code System Code
WHO-VATC QN05CM91
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
NCI_THESAURUS C29709
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
Code System Code Type Description
RXCUI
52016
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY RxNorm
DRUG CENTRAL
1655
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
DRUG BANK
DB11428
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
EPA CompTox
86347-14-0
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
INN
5697
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
PUBCHEM
68602
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
FDA UNII
MR15E85MQM
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
NCI_THESAURUS
C81367
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
EVMPD
SUB08691MIG
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
MERCK INDEX
M7128
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY Merck Index
ChEMBL
CHEMBL77921
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
MESH
D020926
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
CAS
86347-14-0
Created by admin on Sat Jun 26 14:43:12 UTC 2021 , Edited by admin on Sat Jun 26 14:43:12 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> AGONIST
SHORT-ACTING
SALT/SOLVATE -> PARENT
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY