Isuventatug

Approval Year

Substance Class	Protein Created by `admin` on `Wed Apr 02 13:02:30 GMT 2025` Edited by `admin` on `Wed Apr 02 13:02:30 GMT 2025`
Protein Type	MONOCLONAL ANTIBODY
Protein Sub Type	IGG1\|KAPPA
Sequence Origin	HUMANIZED MOUSE
Sequence Type	COMPLETE
Record UNII	MK3GM5GP7S
Record Status	`Validated (UNII)`
Record Version

Download

Name

Type

Language

CLN-619

Preferred Name

English

Isuventatug

Official Name

English

Immunoglobulin G1 [de-451-lysine], anti-(human/Macaca fascicularis/Macaca mulatta/Chlorocebus sabaeus MHC class I chain-related protein MICA/MHC class I chain-related protein MICB) (human-Mus musculus monoclonal CLN-619 ?1-chain), disulfide with human-Mu

Common Name

English

H-gamma1 heavy chain (1-450) [VH (Homo sapiens IGHV3-11*01 (93.8%) -(IGHD) -IGHJ4*01 (100%), CDR-IMGT [8.8.14] (26-33.51-58.97-110)) (1-121) -Homo sapiens IGHG1*03v (100%) G1m3>G1m17, nG1m1 CH1 K120, CH3 E12, M14 (CH1 R120>K (218) (122-219), hinge 1-15 (

Common Name

English

isuventatug [INN]

Common Name

English

immunoglobulin G1-kappa, anti-[Homo sapiens MICA (MIC-A, MH1-like A) and Homo sapiens MICB (MIC-B, MH1-like B)], monoclonal antibody (isuventatug)

Common Name

English

Code System Code Type Description

INN

13415

Created by admin on Wed Apr 02 13:02:30 GMT 2025 , Edited by admin on Wed Apr 02 13:02:30 GMT 2025

PRIMARY

CAS

2986317-23-9

Created by admin on Wed Apr 02 13:02:30 GMT 2025 , Edited by admin on Wed Apr 02 13:02:30 GMT 2025

PRIMARY

FDA UNII

MK3GM5GP7S

Created by admin on Wed Apr 02 13:02:30 GMT 2025 , Edited by admin on Wed Apr 02 13:02:30 GMT 2025

PRIMARY

From	To
1_22	1_96
2_22	2_96
2_148	2_204
2_224	4_219
2_265	2_325
1_148	1_204
2_371	2_429
3_23	3_93
3_139	3_199
4_23	4_93
4_139	4_199
1_224	3_219
1_230	2_230
1_233	2_233
1_265	1_325
1_371	1_429

Glycosylation Type

MAMMALIAN

Glycosylation Link Type	Site
N	1_301
N	2_301

Related Record Type Details


					4V93F2M2T9

MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE A

TARGET->LIGAND

Interaction Type:

IN-VITRO, IN-VIVO

Amount:


					HE7ZR44CS4

MHC CLASS I POLYPEPTIDE-RELATED SEQUENCE B

TARGET->LIGAND

Interaction Type:

IN-VITRO, IN-VIVO

Amount:

Related Record Type Details


					MK3GM5GP7S

Isuventatug

ACTIVE MOIETY

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
AMINO_ACID_SUBSTITUTION		N-TERMINUS	Q	Amount:	PIDOLIC ACID	SZB83O1W42

Name	Property Type	Amount	Referenced Substance	Defining	Parameters	References
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL
Molecular Formula	CHEMICAL
MOL_WEIGHT:NUMBER(CALCULATED)	CHEMICAL