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Details

Stereochemistry ACHIRAL
Molecular Formula C26H36N6O2
Molecular Weight 464.604
Optical Activity NONE
Defined Stereocenters 0 / 0
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of MRT-67307

SMILES

c1cc(cc(c1)Nc2ncc(C3CC3)c(=NCCCN=C(C4CCC4)O)[nH]2)CN5CCOCC5

InChI

InChIKey=UKBGBACORPRCGG-UHFFFAOYSA-N
InChI=1S/C26H36N6O2/c33-25(21-5-2-6-21)28-11-3-10-27-24-23(20-8-9-20)17-29-26(31-24)30-22-7-1-4-19(16-22)18-32-12-14-34-15-13-32/h1,4,7,16-17,20-21H,2-3,5-6,8-15,18H2,(H,28,33)(H2,27,29,30,31)

HIDE SMILES / InChI

Molecular Formula C26H36N6O2
Molecular Weight 464.604
Charge 0
Count
Stereochemistry ACHIRAL
Additional Stereochemistry No
Defined Stereocenters 0 / 0
E/Z Centers 0
Optical Activity NONE

Description
Curator's Comment:: description was created based on several sources, including: https://www.ncbi.nlm.nih.gov/pubmed/21138416 | https://www.ncbi.nlm.nih.gov/pubmed/23033494 | https://www.ncbi.nlm.nih.gov/pubmed/25833948

MRT 67307 dihydrochloride is a novel inhibitor of IKK-epsilon/TBK1. Negative regulation on the canonical IKKs may be critical in preventing the overproduction of the inflammatory mediators that lead to inflammatory and autoimmune diseases. In addition, it was demonstrated that MRT 67307 inhibits series of MARKs and salt inducible kinases (SIKs). SIKs prevent the formation of regulatory macrophages and their inhibition induces increasing in some markers of regulatory macrophages, such as IL-10 and other anti-inflammatory molecules. It is an inhibitor for ULK1and ULK2. ULK1, a serine/threonine protein kinase, is essential for the initial stages of autophagy. Cancer cells are thought to take advantage of autophagy to help them to cope with the stress of tumorigenesis; thus targeting autophagy is an attractive therapeutic approach.

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
19.0 nM [IC50]
160.0 nM [IC50]
27.0 nM [IC50]
52.0 nM [IC50]
36.0 nM [IC50]
41.0 nM [IC50]
250.0 nM [IC50]
67.0 nM [IC50]
430.0 nM [IC50]
230.0 nM [IC50]
900.0 nM [IC50]
45.0 nM [IC50]
38.0 nM [IC50]
Conditions
PubMed

PubMed

TitleDatePubMed
Novel cross-talk within the IKK family controls innate immunity.
2011 Feb 15
The role of TBK1 and IKKε in the expression and activation of Pellino 1.
2011 Mar 15
Phosphorylation of CRTC3 by the salt-inducible kinases controls the interconversion of classically activated and regulatory macrophages.
2012 Oct 16
Pharmacological inhibition of ULK1 kinase blocks mammalian target of rapamycin (mTOR)-dependent autophagy.
2015 May 1
Patents

Sample Use Guides

In Vivo Use Guide
Unknown
Route of Administration: Unknown
Wild-type mouse embryonic fibroblasts (MEFs) were co-transfected with DNA encoding an NF-κB luciferase reporter construct and pTK-RL plasmid DNA. At 24 h post-transfection, the cells were incubated for 1 h without or with 2 uM MRT67307 prior to stimulation with 5 ng/ml IL-1α for the times indicated. MRT67307 enhanced IL-1-stimulated activation of NF-κB dependent gene transcription in wild-type MEFs.
Substance Class Chemical
Created
by admin
on Sat Jun 26 02:24:55 UTC 2021
Edited
by admin
on Sat Jun 26 02:24:55 UTC 2021
Record UNII
MEY37JZ4XR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
MRT-67307
Code English
N-(3-((5-CYCLOPROPYL-2-((3-(4-MORPHOLINYLMETHYL)PHENYL)AMINO)-4-PYRIMIDINYL)AMINO)PROPYL)CYCLOBUTANECARBOXAMIDE
Systematic Name English
MRT67307
Common Name English
CYCLOBUTANECARBOXAMIDE, N-(3-((5-CYCLOPROPYL-2-((3-(4-MORPHOLINYLMETHYL)PHENYL)AMINO)-4-PYRIMIDINYL)AMINO)PROPYL)-
Systematic Name English
Code System Code Type Description
PUBCHEM
44464263
Created by admin on Sat Jun 26 02:24:55 UTC 2021 , Edited by admin on Sat Jun 26 02:24:55 UTC 2021
PRIMARY
CAS
1190378-57-4
Created by admin on Sat Jun 26 02:24:55 UTC 2021 , Edited by admin on Sat Jun 26 02:24:55 UTC 2021
PRIMARY
FDA UNII
MEY37JZ4XR
Created by admin on Sat Jun 26 02:24:55 UTC 2021 , Edited by admin on Sat Jun 26 02:24:55 UTC 2021
PRIMARY
Related Record Type Details
TARGET -> INHIBITOR
Related Record Type Details
ACTIVE MOIETY