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Details

Stereochemistry RACEMIC
Molecular Formula C16H25NO4
Molecular Weight 295.3746
Optical Activity ( + / - )
Defined Stereocenters 0 / 1
E/Z Centers 0
Charge 0

SHOW SMILES / InChI
Structure of ESMOLOL

SMILES

CC(C)NCC(COc1ccc(cc1)CCC(=O)OC)O

InChI

InChIKey=AQNDDEOPVVGCPG-UHFFFAOYSA-N
InChI=1S/C16H25NO4/c1-12(2)17-10-14(18)11-21-15-7-4-13(5-8-15)6-9-16(19)20-3/h4-5,7-8,12,14,17-18H,6,9-11H2,1-3H3

HIDE SMILES / InChI

Molecular Formula C16H25NO4
Molecular Weight 295.3746
Charge 0
Count
Stereochemistry RACEMIC
Additional Stereochemistry No
Defined Stereocenters 0 / 1
E/Z Centers 0
Optical Activity ( + / - )

Description
Curator's Comment:: Description was created based on several sources, including http://www.accessdata.fda.gov/drugsatfda_docs/label/2012/019386s043lbl.pdf

Esmolol (trade name Brevibloc) is a cardioselective beta1 receptor blocker with rapid onset, a very short duration of action, and no significant intrinsic sympathomimetic or membrane stabilizing activity at therapeutic dosages. Esmolol decreases the force and rate of heart contractions by blocking beta-adrenergic receptors of the sympathetic nervous system, which are found in the heart and other organs of the body. Esmolol prevents the action of two naturally occurring substances: epinephrine and norepinephrine. Esmolol predominantly blocks the beta-1 receptors in cardiac tissue. Used for the rapid control of ventricular rate in patients with atrial fibrillation or atrial flutter in perioperative, postoperative, or other emergent circumstances where short term control of ventricular rate with a short-acting agent is desirable. Also used in noncompensatory sinus tachycardia where the rapid heart rate requires specific intervention.

CNS Activity

Curator's Comment:: esmolol does not cross the blood-brain barrier

Approval Year

Targets

Targets

Primary TargetPharmacologyConditionPotency
74.2 µM [IC50]
Conditions

Conditions

ConditionModalityTargetsHighest PhaseProduct
Primary
BREVIBLOC

Approved Use

BREVIBLOC is a beta adrenergic blocker indicated for the short-term treatment of: Control of ventricular rate in supraventricular tachycardia including atrial fibrillation and atrial flutter and control of heart rate in noncompensatory sinus tachycardia Control of perioperative tachycardia and hypertension

Launch Date

5.36284791E11
Primary
BREVIBLOC

Approved Use

BREVIBLOC is a beta adrenergic blocker indicated for the short-term treatment of: Control of ventricular rate in supraventricular tachycardia including atrial fibrillation and atrial flutter and control of heart rate in noncompensatory sinus tachycardia Control of perioperative tachycardia and hypertension

Launch Date

5.36284791E11
Cmax

Cmax

ValueDoseCo-administeredAnalytePopulation
0.22 μg/mL
0.5 mg/kg single, intravenous
dose: 0.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
0.56 μg/mL
1 mg/kg single, intravenous
dose: 1 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
0.96 μg/mL
1.5 mg single, intravenous
dose: 1.5 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
AUC

AUC

ValueDoseCo-administeredAnalytePopulation
0.02 μg × h/mL
0.5 mg/kg single, intravenous
dose: 0.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
0.03 μg × h/mL
1 mg/kg single, intravenous
dose: 1 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
0.06 μg × h/mL
1.5 mg single, intravenous
dose: 1.5 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
T1/2

T1/2

ValueDoseCo-administeredAnalytePopulation
3.65 min
0.5 mg/kg single, intravenous
dose: 0.5 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
4.77 min
1 mg/kg single, intravenous
dose: 1 mg/kg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
4.76 min
1.5 mg single, intravenous
dose: 1.5 mg
route of administration: Intravenous
experiment type: SINGLE
co-administered:
ESMOLOL plasma
Homo sapiens
population: HEALTHY
age: ADULT
sex: FEMALE / MALE
food status: UNKNOWN
Funbound

Funbound

ValueDoseCo-administeredAnalytePopulation
45%
ESMOLOL plasma
Homo sapiens
population: UNKNOWN
age: UNKNOWN
sex: UNKNOWN
food status: UNKNOWN
Doses

Doses

DosePopulationAdverse events​
400 ug/kg/min single, intravenous
Dose: 400 ug/kg/min
Route: intravenous
Route: single
Dose: 400 ug/kg/min
Sources:
unhealthy, 15 years
n = 1
Health Status: unhealthy
Condition: hypertrophic cardiomyopathy
Age Group: 15 years
Sex: M
Population Size: 1
Sources:
Disc. AE: Delirium...
AEs leading to
discontinuation/dose reduction:
Delirium (1 patient)
Sources:
500 ug/kg single, intravenous (mean)
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, adult
n = 369
Health Status: unhealthy
Condition: supraventricular tachycardia
Age Group: adult
Sex: unknown
Population Size: 369
Sources:
Other AEs: Hypotension asymptomatic, Hypotension symptomatic...
Other AEs:
Hypotension asymptomatic (25%)
Hypotension symptomatic (12%)
Infusion site reactions (8%)
Nausea (7%)
Dizziness (3%)
Somnolence (3%)
Sources:
500 ug/kg single, intravenous (mean)
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, mean 44 years
n = 20
Health Status: unhealthy
Condition: ASA physical status I-III
Age Group: mean 44 years
Population Size: 20
Sources:
500 ug/kg single, intravenous
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, mean 58 years
n = 16
Health Status: unhealthy
Condition: out-of-hospital cardiac arrest
Age Group: mean 58 years
Sex: M+F
Population Size: 16
Sources:
AEs

AEs

AESignificanceDosePopulation
Delirium 1 patient
Disc. AE
400 ug/kg/min single, intravenous
Dose: 400 ug/kg/min
Route: intravenous
Route: single
Dose: 400 ug/kg/min
Sources:
unhealthy, 15 years
n = 1
Health Status: unhealthy
Condition: hypertrophic cardiomyopathy
Age Group: 15 years
Sex: M
Population Size: 1
Sources:
Hypotension symptomatic 12%
500 ug/kg single, intravenous (mean)
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, adult
n = 369
Health Status: unhealthy
Condition: supraventricular tachycardia
Age Group: adult
Sex: unknown
Population Size: 369
Sources:
Hypotension asymptomatic 25%
500 ug/kg single, intravenous (mean)
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, adult
n = 369
Health Status: unhealthy
Condition: supraventricular tachycardia
Age Group: adult
Sex: unknown
Population Size: 369
Sources:
Dizziness 3%
500 ug/kg single, intravenous (mean)
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, adult
n = 369
Health Status: unhealthy
Condition: supraventricular tachycardia
Age Group: adult
Sex: unknown
Population Size: 369
Sources:
Somnolence 3%
500 ug/kg single, intravenous (mean)
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, adult
n = 369
Health Status: unhealthy
Condition: supraventricular tachycardia
Age Group: adult
Sex: unknown
Population Size: 369
Sources:
Nausea 7%
500 ug/kg single, intravenous (mean)
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, adult
n = 369
Health Status: unhealthy
Condition: supraventricular tachycardia
Age Group: adult
Sex: unknown
Population Size: 369
Sources:
Infusion site reactions 8%
500 ug/kg single, intravenous (mean)
Recommended
Dose: 500 ug/kg
Route: intravenous
Route: single
Dose: 500 ug/kg
Sources:
unhealthy, adult
n = 369
Health Status: unhealthy
Condition: supraventricular tachycardia
Age Group: adult
Sex: unknown
Population Size: 369
Sources:
Sourcing

Sourcing

Vendor/AggregatorIDURL
PubMed

PubMed

TitleDatePubMed
Determination of radical yields in solid-state drugs as one technique to identify drugs that will withstand radiosterilization: radioresistance of beta blockers.
2003 Jul
[Successful control of rapid heart rate with atrial flutter by intravenous administration of esmolol in a patient after total correction of the tetralogy of Fallot].
2004 Aug
[Intermittent complete left bundle branch block during general anesthesia].
2004 Dec
The use of multi-frequency EPR techniques to identify the radicals produced in irradiated beta-blockers.
2004 Jan
The effect of intermittent low speed mode upon aortic valve opening in calves supported with a Jarvik 2000 axial flow device.
2005 Mar-Apr
Administration of esmolol in microlaryngeal surgery for blunting the hemodynamic response during laryngoscopy and tracheal intubation in cigarette smokers.
2007 Feb
Patents

Patents

Sample Use Guides

Supraventricular tachycardia (SVT) or noncompensatory sinus tachycardia Optional loading dose: 500 mcg per kg infused over one minute Then 50 mcg per kg per minute for the next 4 minutes Adjust dose as needed to a maximum of 200 mcg per kg per minute Additional loading doses may be administered
Route of Administration: Intravenous
In unpaced Langendorff-perfused rat hearts, esmolol (0.03-3 mmol/L) had a profound negative inotropic effect resulting in diastolic arrest at 1 mmol/L and above.
Substance Class Chemical
Created
by admin
on Sat Jun 26 16:13:55 UTC 2021
Edited
by admin
on Sat Jun 26 16:13:55 UTC 2021
Record UNII
MDY902UXSR
Record Status Validated (UNII)
Record Version
  • Download
Name Type Language
ESMOLOL
INN   MI   VANDF   WHO-DD  
INN  
Official Name English
ESMOLOL [WHO-DD]
Common Name English
ESMOLOL [MI]
Common Name English
(+/-)-METHYL P-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)HYDROCINNAMATE
Common Name English
ESMOLOL [VANDF]
Common Name English
ASL-8052-001
Code English
3-(4-(2-HYDROXY-3-(ISOPROPYLAMINO)PROPOXY)PHENYL)PROPIONIC ACID METHYL ESTER
Systematic Name English
BENZENEPROPANOIC ACID, 4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)-, METHYL ESTER, (+/-)-
Common Name English
ESMOLOL [INN]
Common Name English
BENZENEPROPANOIC ACID, 4-(2-HYDROXY-3-((1-METHYLETHYL)AMINO)PROPOXY)-, METHYL ESTER
Systematic Name English
(+/-)-ESMOLOL
Common Name English
Classification Tree Code System Code
NDF-RT N0000000161
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
WHO-VATC QC07AB09
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
NCI_THESAURUS C29576
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
WHO-ATC C07AB09
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
NDF-RT N0000175556
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
Code System Code Type Description
LACTMED
Esmolol
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY
FDA UNII
MDY902UXSR
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
PRIMARY
ChEMBL
CHEMBL768
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
PRIMARY
CAS
103598-03-4
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
SUPERSEDED
DRUG CENTRAL
1054
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
PRIMARY
WIKIPEDIA
ESMOLOL
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY
IUPHAR
7178
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY
NCI_THESAURUS
C72617
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY
CAS
84057-94-3
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
SUPERSEDED
RXCUI
49737
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY RxNorm
INN
5365
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY
EPA CompTox
81147-92-4
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
PRIMARY
PUBCHEM
59768
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY
DRUG BANK
DB00187
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
PRIMARY
EVMPD
SUB13718MIG
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
PRIMARY
MERCK INDEX
M5025
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY Merck Index
MESH
C036604
Created by admin on Sat Jun 26 16:13:57 UTC 2021 , Edited by admin on Sat Jun 26 16:13:57 UTC 2021
PRIMARY
CAS
81147-92-4
Created by admin on Sat Jun 26 16:13:56 UTC 2021 , Edited by admin on Sat Jun 26 16:13:56 UTC 2021
PRIMARY
Related Record Type Details
ENANTIOMER -> RACEMATE
SALT/SOLVATE -> PARENT
TARGET -> AGONIST
SHORT-ACTING
SALT/SOLVATE -> PARENT
ENANTIOMER -> RACEMATE
Related Record Type Details
ACTIVE MOIETY