Cadapersen

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National Institutes of Health Divider Arrow

NCATS

Approval Year

Substance Class	Nucleic Acid Created by `admin` on `Wed Apr 02 20:45:17 GMT 2025` Edited by `admin` on `Wed Apr 02 20:45:17 GMT 2025`
Nucleic Acid Type	OLIGONUCLEOTIDE
Sequence Origin	SYNTHETIC
Sequence Type	COMPLETE
Record UNII	M9A6K387HU
Record Status	`Validated (UNII)`
Record Version

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Name

Type

Language

DNA, d(C-A-(2?-O,4?-C-methylene)m5rC-sp-(2?-O,4?-C-methylene)m5rC-sp-T-sp-A-sp-T-sp-T-sp-T-sp-A-sp-A-sp-C-sp-A-sp-T-sp-C-sp-(2?-O,4?-C-methylene)rA-sp-(2?-O,4?-C-methylene)rG-sp-(2?-O,4?-C-methylene)rA-sp-(2?-O,4?-C-methylene)m5rC), 5?-[6-[[N2,N6-bis[2-[

Preferred Name

English

Cadapersen

Official Name

English

all-P-ambo-2'-deoxycytidylyl-(3'?5')-2'-deoxyadenylyl-(3'?5')-5-methyl-2'-O,4'-C-methylene-P-thiocytidylyl-(3'?5')-5-methyl-2'-O,4'-C-methylene-P-thiocytidylyl-(3'?5')-P-thiothymidylyl-(3'?5')-2'-deoxy-P-thioadenylyl-(3'?5')-P-thiothymidylyl-(3'?5')-P-th

Common Name

English

cadapersen [INN]

Common Name

English

Code System Code Type Description

SMS_ID

300000031575

Created by admin on Wed Apr 02 20:45:17 GMT 2025 , Edited by admin on Wed Apr 02 20:45:17 GMT 2025

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CAS

2924115-64-8

Created by admin on Wed Apr 02 20:45:17 GMT 2025 , Edited by admin on Wed Apr 02 20:45:17 GMT 2025

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NCI_THESAURUS

C211787

Created by admin on Wed Apr 02 20:45:17 GMT 2025 , Edited by admin on Wed Apr 02 20:45:17 GMT 2025

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FDA UNII

M9A6K387HU

Created by admin on Wed Apr 02 20:45:17 GMT 2025 , Edited by admin on Wed Apr 02 20:45:17 GMT 2025

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INN

13151

Created by admin on Wed Apr 02 20:45:17 GMT 2025 , Edited by admin on Wed Apr 02 20:45:17 GMT 2025

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Sugar	Site Range	Site Count
Deoxyribose (DNA)	1_1-1_2;1_5-1_15	13 / 19
	1_3-1_4;1_16-1_19	6 / 19

Linkage	Site Range	Site Count
Phosphate	1_2-1_3	2 / 18
Phosporothioate	1_4-1_19	16 / 18

Related Record Type Details


					L4766ELH5T

PROGRAMMED CELL DEATH 1 LIGAND 1

TARGET->INHIBITOR OF EXPRESSION

Amount:

Related Record Type Details


					M9A6K387HU

ACTIVE MOIETY

Comments:

programmed death-ligand 1 (PD-L1) synthesis reducer

Amount:

Structural Modifications

Modification Type	Location Site	Location Type	Residue Modified	Extent	Fragment Name	Fragment Approval
NUCLEOSIDE BASE SUBSTITUTION	[1_3] [1_4] [1_19]	SITE_SPECIFIC	C		5-METHYLCYTOSINE	6R795CQT4H
NUCLEOTIDE SUBSTITUTION	[1_1]	C-TERMINUS	C		Cadapersen 5'-modification	U89B5T76HE